Blood
Articles in this Issue
Targeting the METTL1/m7G axis as a therapeutic strategy in myeloid leukemia
Abstract N7-methylguanosine (m7G), a prevalent modification in transfer RNAs (tRNAs), is primarily catalyzed by the methyltransferase METTL1. Although growing evidence supports a r...
Venetoclax combinations in untreated CLL: 5-year results and patient-reported outcomes analysis of the CLL13/GAIA trial
Abstract Fixed-duration venetoclax combinations have become a standard first-line treatment in chronic lymphocytic leukemia (CLL). The phase 3 CLL13/GAIA trial assesses 3 time-limi...
Pathogenic role of serpin B3-positive neutrophils in reinforcing thrombus stiffening during ischemic stroke
Abstract The contribution of immune cells to thrombus architecture and mechanical properties in acute ischemic stroke (AIS) remains poorly understood. Using 3-dimensional imaging a...
Signal AML stem cells to home: written and sent by METTL1
Immune-mediated side effects of cancer immunotherapies
Abstract Immunotherapies, such as allogeneic hematopoietic cell transplantation and infusion of chimeric antigen receptor (CAR) T cells have significantly extended our therapeutic...
The clot stiffens: neutrophil serpin B3 in ischemic stroke
Gonadal function and fertility after Hodgkin lymphoma treatment with nivolumab-AVD in the phase 2 GHSG NIVAHL trial
Abstract In 82 patients with classic Hodgkin lymphoma, stable gonadal hormone levels were observed up to 24 months after nivolumab in combination with doxorubicin, vinblastine, and...
Frontline CLL: lessons from the final analysis of CLL13-GAIA
Multinucleated plasma cells and IgG λ myeloma in a patient with TEMPI syndrome and renal cell carcinoma
The prevalence and clinical significance of clonal monocytosis
Abstract The terms clonal monocytosis of undetermined significance (CMUS) and clonal cytopenia and monocytosis of undetermined significance (CCMUS) were introduced by the Internati...
The RELEVANCE of long-term follow-up in follicular lymphoma
Lenalidomide plus rituximab for previously untreated advanced follicular lymphoma: the 10-year RELEVANCE trial analysis
Abstract In the multinational, phase 3 RELEVANCE trial, 1030 patients with previously untreated follicular lymphoma were randomized to receive rituximab + lenalidomide (R2; n = 513...
Monocytes matter: prognostic impact in clonal hematopoiesis
Less is more in primary cutaneous indolent B-cell lymphoma
Diefenbach CS, Jegede O, Wang V, et al. A randomized phase 2 study of ipilimumab, nivolumab, and brentuximab vedotin in patients with relapsed Hodgkin lymphoma. <i>Blood</i> . 2026;147(18):2041-2052.
Radiotherapy for indolent primary cutaneous B-cell lymphoma: an international multicenter ILROG analysis
Abstract Radiotherapy is an established treatment for low-grade primary cutaneous B-cell lymphoma. Recommendations on its use differ internationally, which prompted our group to co...
Ticks and transfusions: a potentially fatal mix!
Platelets under pressure: a sticky outside-in problem
The 10-year RELEVANCE trial analysis
A novel G13-RAPGEF2-RAP1 signaling pathway critical for platelet adhesion and aggregation
Abstract Hemostasis and thrombosis are strongly dependent on the unique ability of platelets to rapidly activate integrin receptors and to firmly adhere to sites of injury under sh...
Severe allergic transfusion reactions to group B/AB plasma or platelets in group O recipients are linked to α-Gal sensitization
Abstract Allergic transfusion reactions (ATR) are potentially lethal adverse events that occur in ∼0.3% to 6% of plasma or platelet transfusions. The main mechanism described is an...