Blood
Articles in this Issue
Efficacy and safety of CAR-t cell therapy in richter transformation: A systematic review
Abstract Introduction: Richter transformation (RT), defined as the progression of chronic lymphocytic leukemia (CLL) into an aggressive lymp...
Implementing patient-centered PROMs in sickle cell disease care: A european consensus approach
Abstract Introduction Sickle cell disease (SCD) is a chronic disorder characterized by varied clinical outcomes, multi-o...
Dex and IL-7 enhance persistence of CAR T cells to promote long-term remission in mouse models of multiple myeloma
Abstract Introduction: Chimeric antigen receptor (CAR) T cells have had phenomenal response rates in hematological malignancies, including &...
Risk of second primary malignancies among CLL survivors across treatment eras: A SEER-based study with racial and ethnic stratification
Abstract Introduction: Survivors of Chronic Lymphocytic Leukemia (CLL) are at increased risk of second primary malignancies (SPM). Treatment...
Concurrent viral infection as an adverse prognostic factor in diffuse large B-cell lymphoma, not otherwise specified
Abstract Background and Objectives Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin lymphoma, exhibits high clin...
Etoposide-cytarabine-pegfilgrastim (EAP) and disease-specific chemotherapy regimens for hematopoietic stem cell mobilization in lymphoma: A randomized phase III trial
Abstract Background: Enough hematopoietic stem cell (HSC) collection is essential for successful autologous stem cell tr...
Qualitative interviews exploring the patient experience of fatigue in individuals with sickle cell disease (SCD), thalassemia, and pyruvate kinase (PK) deficiency
Abstract Introduction: Hereditary hemolytic anemias (HHAs), including sickle cell disease (SCD), thalassemia, and pyruvate kinase (PK) defic...
Precision targeting of pathogenic B cells and autoantibodies in systemic lupus erythematosus using CAR T cells against the IGHV4-34 B cell receptor
Abstract Introduction: Systemic lupus erythematosus (SLE) is a serious autoimmune disease which chiefly involves B-cell dysregulation and ac...
Low-dose lenalidomide for maintenance of remission in primary central nervous system lymphoma: A single-center experience.
Abstract Background: Curative therapy for primary central nervous system lymphoma (PCNSL) consists of methotrexate-based induction therapy f...
Beyond TP53: Molecular IPSS-genes multihit status revisited
Abstract Introduction Molecular profiling has improved risk assessment in myelodysplastic syndromes (MDS), leading to th...
Area deprivation index independently predicts outcomes in IPSS-R higher-risk myelodysplastic syndromes at a major cancer center
Abstract Introduction: The Area Deprivation Index (ADI), which measures neighborhood disadvantage using 17 socioeconomic factors, is a well-...
Single-cell transcriptomics reveals pathogenic interactions between clonal plasma cells and monocytes in POEMS syndrome
Abstract Introduction: POEMS syndrome is a rare plasma cell disorder, primarily characterized by polyneuropathy, organomegaly, endocrinopathy...
Blinatumomab and ponatinib demonstrates ongoing efficacy as frontline therapy in Philadelphia positive B-cell acute lymphoblastic leukemia: Long-term follow-up from a phase 2 Study
Abstract Background The chemotherapy-free combination of blinatumomab (blina) and the potent pan-BCR-ABL tyrosine kinase inhibitor (TKI) pon...
Role of race in severity and survival of those with cutaneous T-cell lymphoma
Abstract Background: Cutaneous T-Cell Lymphoma (CTCL) currently affects over 10.2 million people worldwide. Staphylococcal enterotoxin produ...
Pharmacokinetic (PK)-guided vs weight-based dosing of hydroxyurea for tanzanian children with sickle cell anemia
Abstract Introduction: Hydroxyurea titrated to achieve mild myelosuppression affords the greatest benefits for children with sickle cell ane...
Effect of GVHD prophylaxis on renal function and survival outcomes in allogeneic hematopoietic cell transplant patients with pre-existing renal impairment
Abstract Background: Renal impairment (RI) is a common comorbidity identified during pre-transplant evaluation and is a well-established ris...
Standard transcranial doppler as a resource-efficient first step to screen for MRA-defined cerebral vasculopathy in adults with sickle cell disease
Abstract Background Cerebral vasculopathy in sickle cell disease (SCD) is associated with thrombotic and hemorrhagic stroke. Magnetic resona...
Final results of a phase 1 trial with soquelitinib (SQL), a selective interleukin-2-inducible T cell kinase (ITK) inhibitor for treatment of relapsed/refractory (R/R) T cell lymphomas (TCL)
Abstract Introduction ITK is expressed in T cells and NK cells and is involved in multiple signaling pathways including T cell receptor (TCR...
SPPL3-glycosylation axis governs CD22 CAR T-cell susceptibility in B-ALL independent of antigen recognition
Abstract Introduction: CD22-targeted chimeric antigen receptor (CAR) T-cell therapy has shown promising efficacy in relapsed/refractory B-ce...
Training program for DATA managers in hematopoietic cell transplantation and advanced cell therapy: A nine-year overview from Brazil
Abstract Background: Until 2016, Brazil lacked a centralized registry for hematopoietic cell transplantation (HCT), limiting national outcom...
Utility and sensitivity of wett-SA53 to measure dysgeusia associated with talquetamab, a GPRC5D×CD3 bispecific antibody, in Relapsed/Refractory multiple myeloma: Preliminary data from the talisman study
Abstract Introduction: Talquetamab (Tal) is the first GPRC5D×CD3 bispecific antibody approved for the treatment of relapsed/refractory multi...
Overall survival and prognostic factors of adult patients with acute promyelocytic leukemia in the pre- all-trans-retinoic acid + arsenic trioxide (ATRA+ATO) era and the post-ATRA+ATO era in the US
Abstract Background Since late 1980s there were no significant therapeutic advances for Acute Promyelocytic Leukemia (APL)1. The results of...
Transfusion dependence is associated with poor survival in MDS-h and MDS-LB, while transplantation improves outcomes
Abstract Hypoplastic myelodysplastic neoplasms (MDS-h) and MDS with low blasts (MDS-LB) are characterized by low blasts and absence of defin...
Trends and disparities in anemia and COPD-related mortality among adults in the United States from 1999 to 2023: A CDC wonder database analysis
Abstract Introduction: Anemia and COPD are among the most common diseases in the United States, and when paired, accelerate morbidity and mo...
The resistec study: Dissecting immune correlates of resistance and response to teclistamab in real-world multiple myeloma
Abstract Introduction Although the introduction of proteasome inhibitors, immunomodulatory drugs (IMiDs), and anti-CD38 monoclonal antibodie...