Blood
Articles in this Issue
Targeting CD38 with daratumumab for platelet transfusion refractoriness in aplastic anemia
Abstract We found that 8 of 10 patients with aplastic anemia experienced resolution of platelet transfusion refractoriness following daratumumab administration. Notably, 4 responders...
Aberrant single-cell phenotype and clinical implications of genotypically defined polyclonal plasma cells in myeloma
Abstract Multiple myeloma (MM) is driven by clonal plasma cell (cPC)–intrinsic factors and changes in the tumor microenvironment (TME). To investigate whether residual polyclonal PCs...
Genotype-specific immune responses at the intestinal barrier predispose to colitis in mouse models of chronic granulomatous disease
Abstract Chronic granulomatous disease (CGD) is an inborn error of immunity that is caused by defects in any 1 of the 5 subunits (gp91phox, p47phox, p22phox, p67phox, p40phox) that f...
Activated protein C takes a bite out of factor Va
Cryo-EM structure of coagulation factor Va bound to activated protein C
Abstract Coagulation factor Va (FVa) is the cofactor component of the prothrombinase complex required for rapid generation of thrombin from prothrombin in the penultimate step of the...
Use of machine learning techniques to predict poor survival after hematopoietic cell transplantation for myelofibrosis
Abstract With the incorporation of effective therapies for myelofibrosis (MF), accurately predicting outcomes after allogeneic hematopoietic cell transplantation (allo-HCT) is crucia...
It takes 2 to inflame: microbiota and genotype shape CGD IBD
Pathogenesis of paroxysmal nocturnal hemoglobinuria
Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant clonal hematopoietic disorder. There are 2 components to the pathogenesis of PNH: (1) a mutant stem cell and (2)...
When the silence speaks: T-cell dysfunction in myeloma
B-lymphoblastic leukemia with <i>KMT2A</i> rearrangement with mature B-cell phenotype and surface λ light-chain restriction
A controlled trial for preventing priapism in sickle cell anemia: hydroxyurea plus placebo vs hydroxyurea plus tadalafil
Abstract Recurrent ischemic priapism is a common complication of sickle cell anemia (SCA) and is associated with devastating physical and psychosocial consequences. All previous tria...
The evolving landscape of hereditary stomatocytosis
Abstract Hereditary stomatocytosis represents a heterogeneous group of inherited erythrocyte membrane defects characterized by hemolytic anemia of variable degree, with alterations i...
More than myeloma: the trouble with “normal” plasma cells
Expansions of circulating plasmablasts producing commensal-reactive IgA antibodies are predictors for chronic GVHD
Abstract Chronic graft-versus-host disease (cGVHD) is characterized by dysregulation of the adaptive immune system, including an aberrant B-cell homeostasis after allogeneic hematopo...
Hallmarks of T-cell exhaustion and antigen experience are absent in multiple myeloma from diagnosis to maintenance therapy
Abstract Dysregulation of the bone marrow (BM) niche in multiple myeloma (MM) alters the composition and state of resident immune cells, potentially impeding antitumor immunity. One...