Proceedings of the National Academy of Sciences
Articles in this Issue
Nucleic acid base pair open states by hydrogen exchange
Nucleic acid base pair open states that are actively driven to expose normally hidden sequences and host reactions with processing proteins have been highly studied. However, the spontaneous natural b...
<i>Legionella</i> effector Ceg10 acetylates RPS20 to inhibit host translation and induce cell cycle arrest
Legionella pneumophila , the causative agent of Legionnaires’ disease, utilizes a type IV secretion system (T4SS) to translocate effectors into host cells, modulating diverse cellu...
Multiscale mitochondrial cristae remodeling links Opa1 downregulation to reduced OXPHOS capacity in aged hearts
Aging is closely associated with cardiovascular diseases, the leading cause of mortality worldwide. Mitochondrial dysfunction is a hallmark of cardiovascular aging. Most of the heart’s ATP is produced...
Detoxification of conifer antimicrobial defenses promotes entomopathogenic fungus infection of bark beetles
After consumption by herbivores, plant antimicrobial defense compounds may enhance herbivore immunity to pathogenic microbes. In conifer-bark beetle interactions, beetles ingest large quantities of ph...
Strategies reimagined: SDG-driven solutions for combating global desertification
Desertification threatens 24% of the world’s land area across 126 countries and affects 35% of the global population. However, mainstream global efforts to combat desertification prioritize short-term...
Ebola virus matrix protein VP40 triggers inflammatory responses linked to the ebolavirus virulence
Uncontrolled systemic inflammatory responses are a critical pathological feature of fatal Ebola virus (EBOV) infection. While some inflammatory responses may originate from mononuclear phagocytes (MNP...