Proceedings of the National Academy of Sciences
Articles in this Issue
TAZ integrates ECM remodeling with uterine stromal differentiation to maintain early pregnancy
The uterine microenvironment is critical for establishing pregnancy and sustaining embryonic development. Embryo attachment induces profound endometrial transformation, including stromal differentiati...
Migration-linked TB epidemics: How TB elimination in high-income countries depends on the success of TB control in high-burden settings
Mycobacterium tuberculosis is the leading global cause of infectious disease deaths. A growing proportion of tuberculosis cases in high-income countries occur among foreign-born in...
Persuading large language models to comply with objectionable requests
Are large language models (LLMs) susceptible to the same persuasive appeals as humans? We tested whether classic persuasion principles (authority, commitment, liking, reciprocity, scarcity, social pro...
Pneumococcal membrane particles promote serotype-independent cellular and humoral immunity and protect against pneumococcal colonization
Despite implementation of pneumococcal conjugated vaccines (PCVs) against Streptococcus pneumoniae infections, these...
A BCG hydrogel enables localized NOD2/STING activation to overcome resistance to immune checkpoint blockade
Resistance to immune checkpoint blockade (ICB) often arises from immunologically cold tumors enriched in suppressive myeloid cells. Previous studies have implicated NOD2 signaling in antitumor immunit...
Large language models pass a standard three-party Turing test
The Turing test has been widely discussed as a test of machine intelligence, but it also provides a measure of how humans distinguish other humans from machines. We evaluated 4 systems (ELIZA, GPT-4o,...
Leveraging health care settings to strengthen trust in light-touch benefit outreach
Spatially tunable multiomic sequencing using light-driven combinatorial barcoding of molecules in tissues
Mapping the molecular identities and functions of cells within their spatial context is key to understanding the complex interplay within and between tissue neighborhoods. A wide range of methods have...
Electoral politics influence expansion and titling of informal urban settlements
Understanding what and who shapes urban growth and how it unfolds in the Global South is critical to ensure theories and predictive models of urban expansion and, consequently, global environmental ch...
A functional map of the human intrinsically disordered proteome
Intrinsically disordered regions (IDRs) represent at least one-third of the human proteome and defy the established structure–function paradigm. Because IDRs often have limited positional sequence con...
Natural variations in small RNA origin loci generate circuit diversity underlying temperature acclimation in <i> <i>Caenorhabditis elegans</i> </i>
Individuals respond differently to environmental cues because of inherent variations in genome sequences. This study demonstrates that natural variation in small RNA (sRNA) within embryos epigenetical...
The role of reduced aerosol masking from air pollutant emission reductions in recent global warming acceleration (2013–2023)
In recent years, the Earth has likely experienced an accelerated warming trend, raising growing interest in the possible contributing factors. From 2013 to 2023, global anthropogenic air pollutant emi...
Correction for Sava-Segal et al., Narrative “twist” shifts within-individual neural representations of dissociable story features
Reversible superdeformability of hiPSC epithelial cortinoids
Epithelial cortinoids, fluid-filled shells formed from induced pluripotent stem cells (iPSCs), must accommodate large deformations during growth and morphogenesis. Using inflation–deflation assays and...
Reply to Guido et al.: The importance of credibility in outreach interventions
Directed interactions between electrophysiological, vascular, and fluid dynamics in the sleeping brain
Genomic diversity and the domestication history of cotton ( <i>Gossypium hirsutum</i> )
Gossypium hirsutum is the leading fiber crop globally, but its origin as a domesticated plant and patterns of diversity in the wild remain to be elucidated. Here, we use extensive...
Maynard Smith’s analogy, realized: Common ancestry constrains evolutionary percolation through protein space
ECgo: All-optical induction of single endothelial cell injury and capillary occlusion in the brain
The ability to induce endothelial cell (EC) damage in the mouse brain with high spatial precision is invaluable for mechanistic studies of brain capillary injury and repair. Here, we introduce an opti...
Regulation of Pfh1 helicase activity by nucleic acid interactions and mitochondrial SSB
Pif1-family helicases are essential for proper nuclear and mitochondrial genome maintenance, yet the regulation of their activities remains incompletely understood. Here, we use single-molecule manipu...
Systemic electioneering from the evangelical pulpit: Evidence from a computational analysis
Religious institutions’ engagement in prohibited electoral advocacy is a growing concern for democratic governance. In the United States, such mobilization has been especially visible within the evang...
Correction for Corell-Escuin et al., Dermcidin has antiviral activity and protects against influenza
Decisional reference point pathology: A cognitive mechanism for and a correlate of major depressive disorder in humans
The decisional reference point, the central mechanism underlying behavioral economics, conditions our evaluations of all reinforcers. Whether a given event is experienced as positive or negative depen...
Contextualizing research on Latino population health: Commentary on Goldman and Pebley
A human cardiomyocyte screen identifies optimized lipid nanoparticles for in vivo cardiac gene editing
RNA therapeutics offer promising potential for treating heart disease; however, their clinical application has been limited by insufficient cardiac delivery. Here, we developed a screening platform us...