Proceedings of the National Academy of Sciences
Articles in this Issue
Extremism does not stop at borders, and neither should our models
IglF mediates type VI secretion system spike assembly and promotes <i>Francisella</i> virulence
Type VI secretion systems (T6SSs) are widely distributed among Gram-negative bacteria, where they mostly act to promote bacterial warfare. Bacteria from the Francisella...
The functional impact of LGI1 autoantibodies on human CA3 pyramidal neurons
Autoantibodies against leucine-rich glioma inactivated 1 protein (LGI1) lead to limbic encephalitis, a rare neurological autoimmune disorder characterized by faciobrachial dystonic seizures and memory...
How rising ICE activity influences the childcare workforce
Immigrants play a critical role in the US childcare workforce, yet little is known about how immigration enforcement shapes employment in this essential sector. We study how the sharp escalation in co...
Decadal record of continental H <sub>2</sub> reservoirs reveals potential for subsurface microbial life and natural H <sub>2</sub> exploration
Interest in the economic potential for hydrogen for decarbonization and the green energy transition is a recent phenomenon. Major questions remain concerning the concentrations, volumes, and sustainab...
Multivalent mRNA vaccine platform with compatible antigens conferred broad-spectrum protection against orthoebolaviruses’ exposure
Several orthoebolaviruses have been established, including Orthoebolavirus zairense [for Ebola virus (EBOV)], Orthoebolavirus sudanense...
HIV-1 Vif–dependent SUMOylation regulates viral RNA splicing
Reversing the great degradation of nature by reducing factors related to cropland expansion
As one of the main causes of habitat loss, agricultural cropland expansion is a major threat to biodiversity. We analyze past and anticipated future trends in population, per capita crop demand, and c...
Predictions from deep learning propose substantial protein–carbohydrate interplay
Noncovalent interaction between proteins and carbohydrates (sugars, glycans) is the basis for biological functions from metabolic regulation to intercellular recognition. It is a grand challenge to id...
Correction for Zhang et al., Conserved use of tetraspanin CD9 as an entry receptor by rhabdoviruses spanning multiple genera
Emergence of cooperation due to opponent-specific responses in Prisoner’s Dilemma
Complex life would be impossible without cooperation at all levels of biological organization. However, Darwinian selection is commonly believed to favor selfish behavior, making societies of cooperat...
Position-dependent feedback drives scaling and robustness of morphogen gradients
Developmental patterning is remarkably robust to intrinsic and extrinsic variation. Morphogen gradients are a key mechanism driving patterning, and themselves often scale with the size of developing t...
Attention problems and cortical maturation in a large longitudinal sample of youths: The importance of accounting for sex differences
Delayed age-related cortical thinning has been proposed as a biomarker of attention-related psychopathology and attention-deficit/hyperactivity disorder (ADHD), but these findings have not been adequa...
Reply to Zadegan et al.: Spatial dependence is real, but not every correction travels well
Mucinase-engineered cell membrane nanovesicles degrade the glycocalyx shield to potentiate antitumor immunity
The tumor glycocalyx forms a protective shield that masks checkpoint proteins and compromises the efficacy of immunotherapies. While the bacterial protease StcE can degrade this barrier by cleaving O-...
The most efficient origami torus
A paper torus, also called an origami torus, is a torus in three-dimensional space that is made from finitely many triangles which fit together in such a way that the sum of the angles around each ver...