Proceedings of the National Academy of Sciences
Articles in this Issue
Apoptosis-inducing factor starts its activity within mitochondria revealed by in situ vibrational probes
Apoptosis-inducing factor (AIF) is a flavoprotein located in the mitochondrial intermembrane space, and it is believed to trigger caspase-independent cell death after its release from the mitochondria...
A defined community of core gut microbiota members promotes cognitive performance in honey bees
Gut microbiota across animals have been shown to influence host cognition and behavior. However, it remains unclear whether these cognitive effects are driven by specific bacterial species or arise fr...
Plant Kelch phosphatases are Ser/Thr phosphatases involved in cell cycle regulation
Brassinosteroids (BRs) are plant steroid hormones sensed by the membrane receptor kinase BRI1. Activation of BRI1 leads to the dephosphorylation of BZR1/BES1 transcription factors. Overexpression of t...
FGFR1–ETV1–CXCL1 signaling in dermal fibroblast orchestrates fibroblast-associated itch
Fibroblasts are a heterogeneous group of mesenchymal cells essential for tissue homeostasis maintenance and pathological responses. However, the mechanistic contributions of fibroblast plasticity to s...
Molecular de-extinction looks to the past to find the molecules of the future
Correction to Supporting Information for Liu et al., Efficient quantum algorithm for dissipative nonlinear differential equations
TGFb signaling instructs a conserved fibrosis-associated cell state marked by LRRC15
Fibroblasts are key potentiators of chronic disease pathophysiology. Despite their established roles in promoting pathological inflammation and tissue remodeling, activated myofibroblasts are generall...
NRF2 activation by myeloid cell–derived oxidative stress induces SNAI-driven features of EMT in breast cancer
Metastasis is facilitated by epithelial-to-mesenchymal transition (EMT), a process in which epithelial cancer cells, including breast cancer cells, acquire mesenchymal-like phenotypes. Production of r...
Hydraulic geometry hypothesis allows reverse engineering of 3D quasi-equilibrium landscapes from 2D channel networks: Earth, Mars, Titan
The 2D dendritic structure of stream networks within fluvial catchments has not previously been linked to reach-scale channel processes. Existing extensions of 2D network models to 3D landscapes yield...
Chinmo defines the region-specific oncogenic competence in the <i>Drosophila</i> central nervous system
While genetic mutations can promote hyperplastic growth, they do not always result in oncogenic outcomes. We and others have previously identified the transcription factors Nerfin-1 and Lola as inhibi...
A mechanism for substrate quality control in outer membrane protein assembly
The assembly of β-barrel proteins into the outer membrane (OM) of Gram-negative bacteria is catalyzed by the β-barrel assembly machine (Bam) complex, which consists of two essential proteins, the BamA...
OptoRibo-seq for spatiotemporally resolved mapping of the local protein translatome
Localized protein translation occurs in numerous subcellular compartments and regulates diverse biological processes by rapidly changing protein compositions in response to subcellular needs. Existing...
A redox- and proton-coupled inner membrane transporter mediates copper import to the bacterial cytoplasm
Copper homeostasis in bacteria requires tightly regulated import systems to balance copper’s essential redox functions with its inherent cytotoxicity; yet, the mechanisms of cytoplasmic copper uptake...
Transcription start site heterogeneity controls MDA5 sensing of unspliced HIV-1 RNAs
Heterogenous transcription start site (TSS) usage dictates the 5′ leader structure and function of unspliced HIV-1 RNAs (usRNA). We and others have previously reported that expression and Rev/CRM1-med...
Wind turbine proximity and health: Longitudinal evidence from US households
Rapid growth of wind energy plays a key role in global efforts to reduce carbon emissions, yet public concerns persist about its potential health effects, particularly through noise exposure. While so...
Regulatory rewiring of <i>Dand5</i> drove left–right organizer heterotopy and organ asymmetry evolution in chordates
Heterotopy—the spatial relocation of developmental processes—is a key mechanism driving morphological innovation, yet its underlying regulatory basis remains poorly understood. In chordates, the left–...
Molecular insight into the interplay among heterogeneous plasmacytes and microenvironment cells and their clinical relevance in myeloma
Multiple myeloma (MM) develops with the acquisition of genetic abnormalities in plasmacytes and changes in microenvironment cells (MECs). Despite the progress in understanding MM disease mechanism thr...
Detecting changepoints in dynamical systems: Modeling time-varying transmission of seasonal influenza
Seasonal influenza epidemics exhibit complex transmission dynamics influenced by time-varying extrinsic factors such as social behavior and seasonal effects. Estimating changes in transmission rates i...
Genome-wide CG hypomethylation of the <i>Arabidopsis</i> ecotype Cvi linked to structural variation and RNAi at the <i>VIM4</i> – <i>VIM2</i> locus
The Cape Verde Island (Cvi)-0 ecotype, a relict lineage of Arabidopsis thaliana , is characterized by exceptionally low CG methylation levels genome-wide. Numer...
Evolutionary branching and consistency in group cooperation
Understanding the origins of volunteerism and free-riding is crucial in collective action situations where a sufficient number of cooperators is necessary to achieve shared benefits, such as in vaccin...
Dynamic creation of topological solitons via nematic vortex lines
Topologically protected solitonic structures have garnered significant attention in condensed matter physics due to their unique stability and potential applications in next-generation technologies su...
Systematic determination of disulfide bond reduction potentials reveals a nonequilibrium redox hierarchy in cyanobacteria
Disulfide bonds act as reversible switches that regulate cellular function in nearly all organisms. Their behavior is set by the midpoint potential ( E m...
The Greenland shark genome: Insights into lifespan extremes and population dynamics
The Greenland shark ( Somniosus microcephalus ) is known for its slow metabolism and deep-sea habitat. It is thought to be the longest-lived vertebrate on Earth...
Rebinding drives cellular retention of small-molecule drugs with abundant targets
Many small-molecule antitumor drugs are administered far less frequently than would be predicted from their plasma half-lives, in part because their efficacy is driven by prolonged retention within tu...
Combined generalist and host-specific transcriptional strategies enable host generalism in the fungal pathogen <i>Botrytis cinerea</i>
How generalist pathogens infect phylogenetically diverse hosts remains a central question in plant-pathogen biology. In particular, the extent to which broad host range is enabled by genetic variation...