Proceedings of the National Academy of Sciences
Articles in this Issue
China’s one-child policy amplifies intergenerational inequality via enlarged differential fertility
Using the staggered rollout of China’s one-child policy (OCP) across provinces and birth cohorts as a quasi-natural experiment, we demonstrate that differential fertility between richer and poorer hou...
Rates of speciation and past extinctions affect food webs on continental scales
Semantic knowledge guides innovation and drives cultural evolution
Cultural evolution allows ideas and technologies to accumulate across generations, reaching their most complex and open-ended form in humans. While social learning enables the transmission of such inn...
Reading ability in both deaf and hearing adults is linked to neural representations of abstract phonology derived from visual speech
Reading is central to academic and vocational success. Some deaf children face reading challenges due to limited access to spoken or signed language. Robust phonological representations are key to rea...
Phosphoethanolamine cytidylyltransferase 2 integrates DAG metabolism and TBK1 activation to regulate antiviral innate immunity
Phosphatidylethanolamine (PE) biosynthesis is critical for membrane biology and cellular homeostasis. However, its specific role in antiviral innate immunity remains poorly understood. Here, we demons...
Remote sensing enables expansion of our understanding of controls on river width and active floodplain
Polyploidy: A macromutational force pushing bioeconomic developments
Polyploidization, the consequence of genome doubling, is a macromutation that reshapes genomes, phenotypes, and ecological interactions. Polyploidization often results in novel phenotypes, including a...
Volatile signaling in plant– <i>Metarhizium</i> –insect interactions: Implications for nitrogen cycling
Nitrogen exchange between plants and insects is a major component of ecosystem nitrogen cycling. Endophytic insect pathogenic fungi transfer insect-derived nitrogen to plants through symbiotic associa...
Meiosis-specific genes play roles in ploidy reduction in <i>Cryptococcus neoformans</i> titan cells
Cryptococcus neoformans is a fungal pathogen of humans that causes life-threatening meningoencephalitis. During infection, enlarged, polyploid titan cells are produced that promote...
Accessibility–equality dynamics in urban blue and green spaces reshape human well-being
As urbanization accelerates, urban blue and green spaces are increasingly recognized as critical nature-based solutions for enhancing human well-being, delivering climate, environmental, and psycholog...
Social interactions in isolated, confined, and extreme environments: A study of Antarctic winter teams using wearable sensors
Long-duration space missions expose crews to extreme psychological and social stressors due to prolonged isolation and confinement. To examine how such conditions impact individual and team functionin...
Rice paper adsorbent for gold recovery
Growing global interest in gold (Au) has spurred the development of adsorption processes as sustainable technologies for effective Au recovery from industrial waste. However, the adsorbents used in su...
amyloid-predict and LLPS-predict: Predicting phase separation propensities in the intrinsically disordered proteome
Amyloid formation and liquid–liquid phase separation (LLPS) are two important phenomena in cellular biology, linked to both normal physiological functions and various pathologies. Here, we present a c...
Tubulin flux at spastin-induced nanodamage sites regulates microtubule rescue frequency and EB1 lifetimes
Severing enzymes nanodamage microtubules by extracting tubulin subunits. This extraction is accompanied by spontaneous repair with soluble tubulin. Here, we show that GTP-, and not GDP–tubulin, incorp...
Reply to Ritson-Williams et al. and Loya and van Woesik: Coral replacement research is vital due to uncertainty and unprecedented stress
Oxidative stress and serum deprivation influence the evolution of newly formed tetraploid cells during tumorigenesis
We recently found that newly formed tetraploid (4N) cells in culture quickly lose extra centrosomes after whole genome doubling (WGD). This is inconsistent with the high incidence of centrosome number...
Growth under pressure: The pros and cons of polyploidy induced by stress
In native environments, organisms are faced with an array of acute or chronic stresses. These stresses include toxins, pathogens, and physical injury. An increasingly recognized response to diverse st...
Genome evolution through polyploidy: Enhancing plant stress resilience in agriculture
Polyploidy, also known as whole genome duplication, is a major evolutionary force in plants, driving diversification and the generation of novel phenotypic variation, including superior abiotic and bi...
Atomic layer-deposited nucleation layers to control zinc morphology and suppress hydrogen evolution
Aqueous zinc (Zn) batteries are among the most promising candidates for safe, low-cost, and sustainable grid-scale energy storage. However, their practical application is significantly constrained by...
Electrical stimulation promotes longevity and regeneration in a colonial chordate
Endogenous bioelectric currents regulate development and regeneration, but their influence on organismal longevity and stem cell–mediated repair is not well understood. We demonstrate that a brief, cl...
HHIP’s dynamic role in epithelial wound healing reveals a potential mechanism of COPD susceptibility
Genetic variants near Hedgehog interacting protein ( HHIP ) have been consistently associated with increased risk for chronic obstructive pulmonary disease (COP...
Navigating high-order protein fitness landscapes via deep learning on directed evolution trajectories
Accurately predicting the fitness effects of high-order mutations is a grand challenge in understanding and engineering proteins. Existing models, including pretrained protein language models, struggl...
A loaf of bread and a jug of wine: The origins of the ultimate culinary pairing
Ecological replacement versus process-based recovery of Caribbean reefs
Uncovering ParB-dependent and -independent subclasses of T-dioxygenases from bacteriophage
5-Methylpyrimidine dioxygenases (5mYOXs) are iron (II)/2-oxoglutarate-dependent enzymes that catalyze the postreplicative oxidation of DNA 5-methylpyrimidines. Here, we define two subclasses of phage...