Volatile signaling in plant– <i>Metarhizium</i> –insect interactions: Implications for nitrogen cycling

X Xingyuan Tang (State Key Laboratory of Vegetation structure, Function and Construction (VegLab), College of Life Science, Zhejiang University) T Ting Feng (Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University) C Chaonan Yu (State Key Laboratory of Vegetation structure, Function and Construction (VegLab), College of Life Science, Zhejiang University) M Meihong Ni (State Key Laboratory of Vegetation structure, Function and Construction (VegLab), College of Life Science, Zhejiang University) Y Yubo Zhang (Minjiang Collaborative Center for Theoretical Physics, College of Physics and Electronic Information Engineering) X Xin Ma X Xinmiao Wang (GRINM (Guangdong) Institute for Advanced Materials and Technology) J Jiani Chen (Zhejiang Engineering Research Center for Biological Control of Crop Pathogens and Insects, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Ministry of Agriculture and Rural Affairs Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, State Key Lab of Rice Biology and Breeding, Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University) W Wenqi Shi (Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University) R Raymond J. St.Leger (Department of Entomology, University of Maryland) J Jianhua Huang (Zhejiang Engineering Research Center for Biological Control of Crop Pathogens and Insects, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Ministry of Agriculture and Rural Affairs Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, State Key Lab of Rice Biology and Breeding, Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University) W Weiguo Fang (State Key Laboratory of Vegetation structure, Function and Construction (VegLab), College of Life Science, Zhejiang University)

Abstract

Nitrogen exchange between plants and insects is a major component of ecosystem nitrogen cycling. Endophytic insect pathogenic fungi transfer insect-derived nitrogen to plants through symbiotic associations mediated by fungal mycelia, enabling plants to thrive even after losing nitrogen to insects. However, the mechanisms underlying this process remain unexplored. Here, we show that the widespread endophytic entomopathogen Metarhizium robertsii degrades the common root-derived antifungal compound caulilexin C to produce the volatile 1-methoxyindole. This compound is recognized by the Or74a olfactory receptor in Drosophila melanogaster larvae and attracts multiple Dipteran species to the plant– Metarhizium consortium. The recruited insects are subsequently infected and consumed, resulting in enhanced insect-derived nitrogen transfer to the plants. This self-reinforcing mechanism strengthens the plant–fungus symbiosis and reveals a pathway contributing to ecosystem nitrogen flux.

Article Details

Volume / Issue Vol. 123, Issue 22
Published June 02, 2026
ISSN 0027-8424
Publisher National Academy of Sciences

Authors (12)

X

Xingyuan Tang

State Key Laboratory of Vegetation structure, Function and Construction (VegLab), College of Life Science, Zhejiang University

T

Ting Feng

Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University

C

Chaonan Yu

State Key Laboratory of Vegetation structure, Function and Construction (VegLab), College of Life Science, Zhejiang University

M

Meihong Ni

State Key Laboratory of Vegetation structure, Function and Construction (VegLab), College of Life Science, Zhejiang University

Y

Yubo Zhang

Minjiang Collaborative Center for Theoretical Physics, College of Physics and Electronic Information Engineering

X

Xin Ma

X

Xinmiao Wang

GRINM (Guangdong) Institute for Advanced Materials and Technology

J

Jiani Chen

Zhejiang Engineering Research Center for Biological Control of Crop Pathogens and Insects, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Ministry of Agriculture and Rural Affairs Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, State Key Lab of Rice Biology and Breeding, Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University

W

Wenqi Shi

Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University

R

Raymond J. St.Leger

Department of Entomology, University of Maryland

J

Jianhua Huang

Zhejiang Engineering Research Center for Biological Control of Crop Pathogens and Insects, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Ministry of Agriculture and Rural Affairs Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, State Key Lab of Rice Biology and Breeding, Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University

W

Weiguo Fang

State Key Laboratory of Vegetation structure, Function and Construction (VegLab), College of Life Science, Zhejiang University