Polyploidy: A macromutational force pushing bioeconomic developments

Abstract

Polyploidization, the consequence of genome doubling, is a macromutation that reshapes genomes, phenotypes, and ecological interactions. Polyploidization often results in novel phenotypes, including alterations in size, physiology, biochemistry, and enhanced stress tolerance. Here, we discuss how strategically leveraging polyploidy can provide significant advancements within the modern bioeconomy committed to reducing our ecological footprint through the sustainable production and use of biological resources. The bioeconomy spans diverse sectors, including agriculture, health sciences, and biotechnology. By elucidating and leveraging the immediate, or short-term, effects of polyploidization, such as harnessing genetic diversity, extensive biomass production, diversification of metabolites, and improved stress resilience, we highlight how this process unlocks vast, underexplored bioeconomic opportunities. This includes accelerating the exploration of new breeding techniques, speeding up the domestication of new local varieties or medicinal plants, and offering possibilities for improved biofuel production, bioremediation strategies, therapies, and production and discovery of bioactive compounds. The multilayered effects of polyploidization shared across sectors can foster interdisciplinary exchange and are essential for advancing toward a more sustainable bioeconomy.