Proceedings of the National Academy of Sciences
Articles in this Issue
The centrosomal hub unifies regulatory factors of NLRP3 inflammasome activation
The NLRP3 inflammasome is central to host defense and sterile inflammation and forms condensates at the microtubule-organizing center (also known as the centrosome), although the mechanisms regulating...
Single-shot wide-field biochemical imaging at 1 kHz frame rate
Vibrational microspectroscopy, including both Raman-based and infrared-based techniques, can map the chemical distribution of samples based on molecular vibrations without labeling. However, imaging f...
Lhcf2 in the peripheral antenna is essential for nonphotochemical quenching and Lhcx1 accumulation in the diatom <i>Chaetoceros gracilis</i>
Photosynthetic organisms must continuously balance efficient light harvesting with protection against excess excitation energy, a challenge met by nonphotochemical quenching (NPQ). Although the molecu...
Monitoring major biodiversity stronghold in war zones: Model predicts Lake Chad remains Africa’s most important wetland for waterbirds
Lake Chad is both one of the largest transboundary wetlands in Africa and a major biodiversity hotspot. As such, Lake Chad would require sound and long-term biodiversity monitoring, but it is also a w...
Force-responsive symmetric cell divisions orient stomata along global tissue axes
Stomata, microscopic pores that regulate gas exchange in plants, are patterned according to conserved pathways that regulate their physiology. Here, we identify a mode of stomatal patterning that depe...
Three-stage melting of a macroscopic continuous spacetime crystal
A spacetime crystal is a phase of matter that spontaneously develops periodic order in both space and time. Spacetime crystals have been experimentally observed in microscopic quantum many-body system...
Epigenetic regulation of mesenchymal BMP signaling directs postnatal organ innervation
Sensory innervation of developing organs is influenced by molecular cues secreted from surrounding tissues, yet the mechanisms coordinating this tissue–tissue communication are not well understood. To...
People in more individualist cultures are more motivated to make others feel better
In many Western cultures, trying to make others feel better is considered critical for psychological health and social relationships. However, given that people think about emotions and relationships...
Anticipatory and theme-specific neural oscillations predict aesthetic evaluation of poetry
Poetry condenses language into minimal forms, evoking emotion, imagery, and aesthetic judgment, yet the neural basis of such evaluations remains poorly understood. We investigated how the brain evalua...
Arm dominance is an emergent effect of practice executing complex trajectory shapes required by tools and objects
Limb dominance is a human behavioral characteristic with many cultural, practical, scientific, and clinical implications. Yet why the dominant limb performs better across a range of motor skill-requir...
The cannibalistic trade-off: Why human cannibalism emerges and why taboos suppress it
Cannibalism is among the most widespread taboos in human societies, yet archaeological, ethnographic, and historical evidence indicates that it has repeatedly emerged across human populations. This co...
A hierarchical cascade of sleep rhythms supports motor memory and is hijacked by epileptic spikes in human epilepsy
The cross-regional interplay of slow oscillations, spindles, and ripples during sleep is believed to support systems memory consolidation but remains understudied in humans. Using a validated behavior...
CPKs are involved in Ca <sup>2+</sup> signaling encoding by enhancing OST1-initiated Ca <sup>2+</sup> influx for ABA-induced stomatal closure in Arabidopsis
Both Ca 2+ -independent kinase OPEN STOMATA 1 (OST1) and Ca 2+ -DEPENDENT PROTEIN KINASEs (CPKs) play important roles in...
Sensitivity suppression during attention shifts
The brain possesses the remarkable ability to suppress undesirable signals generated by our own actions to ensure accurate perception, like the suppression of retinal motion signals during rapid eye m...
Disruption of dynactin complex function in intellectual disability
Intellectual disability (ID) is a highly prevalent condition affecting approximately 200 millions of people worldwide, characterized by impaired cognitive function. Dynactin complex consists of multip...
A “high-entropy + dilute” design strategy delivers a strong and ductile refractory alloy from 77 to 1,373 K
Refractory high-entropy alloys (RHEAs) are ideal for extreme-temperature structural applications, but strengthening single-phase body-centered cubic (BCC) RHEAs typically compromises ductility, and sy...
Injury-induced tau pathology promotes aggressive behavior in <i>Drosophila</i> without neurodegeneration
The microtubule-associated protein tau is implicated in neurodegenerative diseases, but its physiological roles remain poorly understood. Here, we find that panneuronal expression of human tau (HsTau)...
B cell–intrinsic CXCR3 drives efficient generation of ectopic pulmonary germinal center responses to influenza A virus infection
Chemotactic receptors involved in generation of ectopic pulmonary germinal centers (GCs) within inducible bronchus-associated lymphoid tissue (iBALT) are poorly defined. Here, using CIBER...
Correction for Wang et al., The role of reduced aerosol masking from air pollutant emission reductions in recent global warming acceleration (2013–2023)
A reset clock cannot keep time: Thermal overprinting obscures Great Unconformity origins in North China
European beech reproduction is not reduced by drought, including the 2003, 2018, and 2022 extremes
Climate change is intensifying drought stress in temperate forests, but its effects on tree reproduction, central to forest regeneration and migration capability, remain poorly understood. Here, we an...
Reply to McDannell et al.: Thermal overprinting does not obscure the tectonic origin of the Great Unconformity
Assessment of diverse deep brain stimulation targets uncovers a common neural pathway for instantaneous antidepressant effects in rats
Deep brain stimulation (DBS) is a promising therapeutic modality for managing treatment-resistant depression. Most DBS research has focused on single brain regions resulting in unclear optimal stimula...
Reply to Górski et al.: Polarization requires opinions, not just negative ties
Two-step mechanism of Bruton’s tyrosine kinase membrane recruitment and activation
Peripheral membrane proteins (PMPs) are critical mediators of signaling cascades initiated at the cell surface. Their functions depend on their innate ability to interact dynamically with membranes in...