Proceedings of the National Academy of Sciences
Articles in this Issue
Seismic fault slip at depths simulated by high-velocity friction experiments under hydrothermal conditions
Seismic fault slip and rupture propagation often occur at crustal depths in the presence of hot and pressurized aqueous fluids (i.e., hydrothermal conditions). Previous experiments investigated fault...
Transferring climate change physical knowledge
Precise and reliable climate projections are required for climate adaptation and mitigation, but Earth system models still exhibit great uncertainties. Several approaches have been developed to reduce...
Multiplexing of cognitive encoding by oculomotor networks leads to incidental gaze shifts
Humans and other animals are adept at learning to perform cognitively demanding behavioral tasks. Neurophysiological recordings in nonhuman primates during such tasks find that the requisite cognitive...
Maximizing underwater energy harvesting efficiency using flexible solar cells: A pathway to sustainable ocean power
Photovoltaic technology has emerged as a key candidate for powering underwater devices. However, traditional solar cells face limitations in real marine environments. Flexible solar cells offer new po...
Structural and functional characterization of the brain-specific dynamin superfamily member RNF112
Most members of the dynamin superfamily of large guanosine triphophatases (GTPases) have an ability to remodel membranes in response to guanosine triphosphate (GTP) hydrolysis. Ring Finger Protein 112...
Alpha-tubulin tails regulate axoneme differentiation
The tubulin tail is a key element for microtubule (MT) functionality, but the functional redundancy of tubulin genes complicates the genetic determination of their physiological functions. Here, we re...
Structural basis for immune cell binding of <i>Fusobacterium nucleatum</i> via the trimeric autotransporter adhesin CbpF
Fusobacterium nucleatum (Fn), a commensal in the human oral cavity, is overrepresented in the colon microbiota of colorectal cancer (CRC) patients and is linked to tumor chemoresis...
Cortical scaling of the neonatal brain in typical and altered development
Theoretically derived scaling laws capture the nonlinear relationships between rapidly expanding brain volume and cortical gyrification across mammalian species and in adult humans. However, the prese...
Activity of spinal RORβ neurons is related to functional improvements following combination treatment after complete SCI
Various strategies targeting spinal locomotor circuitry have been associated with functional improvements after spinal cord injury (SCI). However, the neuronal populations mediating beneficial effects...
Probing ultraweak in-plane magnetic anisotropy within a two-dimensional layered antiferromagnet
Magnetic anisotropy plays a crucial role in determining the critical behavior and phase transitions in two-dimensional magnetic systems. It is also required for the design of thin-film spintronic devi...
Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit
The integrated stress response (ISR) is a central signaling network that enables eukaryotic cells to respond to a variety of different environmental stresses. Such stresses cause ribosome collisions t...
The fruit fly, <i>Drosophila melanogaster</i> , as a microrobotics platform
Engineering small autonomous agents capable of operating in the microscale environment remains a key challenge, with current systems still evolving. Our study explores the fruit fly,...
Conformational signatures induced by ubiquitin modification in the amyloid-forming tau repeat domain
Posttranslational modifications can critically affect conformational changes of amyloid-forming proteins. Ubiquitination of the microtubule-associated tau protein, an intrinsically disordered biomolec...
The Beholder’s Share: Bridging art and neuroscience to study individual differences in subjective experience
Our experience of the world is inherently subjective, shaped by individual history, knowledge, and perspective. Art offers a framework within which this subjectivity is practiced and promoted, invitin...
Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4
The G protein–coupled cysteinyl leukotriene receptor CysLT2R plays intricate roles in the physiology and pathogenesis of inflammation-related processes. It has garnered increasing attention as a poten...
Ultra narrowband geometric-phase resonant metasurfaces
The concept of a geometric phase has sparked a revolution in photonics. Conventional space-variant polarization manipulation in optical systems only results in broadband geometric phases. Recently eme...
The genetic legacy of a global marine invader
The massive geographic expansion of terrestrial plant crops, livestock, and marine aquacultured species during the 19th and 20th centuries provided local economic benefits, stabilized food demands, an...
Emergent gauge fields in band insulators
By explicit microscopic construction involving a mapping to a quantum vertex model subject to the “ice rule,” we show that an electronically “trivial” band insulator with suitable vibrational (phonon)...
Correction to Supporting Information for Karayel et al., Impairment of DET1 causes neurological defects and lethality in mice and humans
Correction for He et al., Radiation-induced cellular plasticity primes glioblastoma for forskolin-mediated differentiation
Mixing microbiomes in vitro reveals rules of community assembly
A monoclonal anti-hemagglutinin stem antibody modified with zanamivir protects against both influenza A and B viruses
Influenza remains a significant public health threat. Both monoclonal antibodies and small-molecule inhibitors can target the influenza surface glycoproteins hemagglutinin (HA) or neuraminidase (NA) f...
Coupling between the lever arm and active site via an N-terminal extension tunes force sensitivity in the myosin-1 family
An integrated AI knowledge graph framework of bacterial enzymology and metabolism
The study of bacterial metabolism holds immense significance for improving human health and advancing agricultural practices. The prospective applications of genomically encoded bacterial metabolism p...
Uniform elementary fibrils in diverse plant cell walls
Plant cell walls are composed of skeletal cellulose and a filling matrix of hemicelluloses and lignin. Cellulose has slender crystallite units referred to as microfibrils or elementary fibrils, and th...