Proceedings of the National Academy of Sciences
Articles in this Issue
ZmGCT1/2 negatively regulate drought tolerance in maize by inhibiting ZmSLAC1 to maintain guard cell turgor
Stomata, which are essential for the exchange of CO 2 and water vapor between plant leaves and the atmosphere, are regulated by a variety of environmental and i...
Inactivation of microglial LXRβ in early postnatal mice impairs microglia homeostasis and causes long-lasting cognitive dysfunction
Microglia, the largest population of brain immune cells, play an essential role in regulating neuroinflammation by removing foreign materials and debris and in cognition by pruning synapses. Since liv...
Neddylation modification stabilizes LC3B by antagonizing its ubiquitin-mediated degradation and promoting autophagy in skin
The Atg8-family proteins, including LC3B (microtubule-associated protein 1 light chain 3 beta), are pivotal for key steps in the autophagy process. Proper regulation of LC3B homeostasis is essential f...
Biallelic variants in the conserved ribosomal protein chaperone gene <i>PDCD2</i> are associated with hydrops fetalis and early pregnancy loss
Pregnancy loss is a major problem in clinical medicine with devastating consequences for families. Next generation sequencing has improved our ability to identify underlying molecular causes, though o...
New Advanced Placement course designed to broaden access promotes participation and demographic diversity in computer science education
Advanced Placement (AP) provides college-level courses to over 1 million US secondary students annually. Black, Hispanic, and female students have historically been underrepresented in AP Computer Sci...
In situ generated hydrogen-bonding microenvironment in functionalized MOF nanosheets for enhanced CO <sub>2</sub> electroreduction
The microenvironment around catalytic sites plays crucial roles in enzymatic catalysis while its precise control in heterogeneous catalysts remains challenging. Herein, the coordinatively unsaturated...
Compositional and topological determinants of a physiological Ashwell–Morell receptor ligand
The hepatocyte Ashwell–Morell receptor (AMR) is the prototypical mammalian lectin and the first cell receptor isolated. This recycling endocytic receptor of the plasma membrane determines the concentr...
Downregulation of Nesprin1 by Runx2 deficiency is critical for the development of skeletal laminopathy-like pathology
Runx2 is a master regulator of bone formation, and its dysfunction causes cleidocranial dysplasia (CCD) in humans. When iPS cells were generated from patients with CCD and Runx2-deficient iPS cells we...
Arf1 and ARFGEF2/Sec71 control neuroblast polarity by anchoring nonmuscle myosin II
Neural stem cells (NSCs) can self-renew and undergo differentiation via asymmetric division. Dysregulation in the balance between self-renewal and differentiation can lead to tumor formation or neurod...
Astrocytic Ryk signaling coordinates scarring and wound healing after spinal cord injury
Wound healing after spinal cord injury involves highly coordinated interactions among multiple cell types, which are poorly understood. Astrocytes play a central role in creating a border against the...
Degenerate domain walls in supersymmetric theories
In supersymmetric Yang–Mills theories tension-degenerate domain walls are typical. Adding matter fields in fundamental representation, we arrive at supersymmetric quantum chromodynamics (SQCD) support...
FLIP <sub>L</sub> permits apoptotic and inflammatory signaling and inhibits necroptosis in mice without Caspase-8 oligomerization
Caspase-8 signaling has proapoptotic, antinecroptotic, and proinflammatory signaling roles dependent on interaction with the adapter molecule FADD, oligomerization, and autocleavage. Previously, a Cas...
Substrate stress relaxation regulates monolayer fluidity and leader cell formation for collectively migrating epithelia
Collective migration of epithelial tissues is a critical feature of developmental morphogenesis and tissue homeostasis. Coherent motion of cell collectives requires large-scale coordination of motion...
On the hidden transient interphase in metal anodes: Dynamic precipitation controls electrochemical interfaces in batteries
The solid–electrolyte interphase (SEI) formed on a battery electrode has been a central area of research for decades. This structurally complex layer profoundly impacts the electrochemical deposition...
Correction for Du et al., The RNA-binding protein RBPMS inhibits smooth muscle cell–driven vascular remodeling in atherosclerosis and vascular injury
Glassy ionogels with high compressibility and strength for impact protection
Solvents within gels enhance the mobility of polymer chain segments while concurrently diminishing interchain interactions, thereby facilitating the ductility of glassy polymers at the cost of their m...
Exploring RNA destabilization mechanisms in biomolecular condensates through atomistic simulations
Biomolecular condensates are currently recognized to play a key role in organizing cellular space and in orchestrating biochemical processes. Despite an increasing interest in characterizing their int...
Roquin exhibits opposing effects on RNA stem-loop stability through its two ROQ domain binding sites
The interaction of mRNA and regulatory proteins is critical for posttranscriptional control. For proper function, these interactions, as well as the involved protein and RNA structures, are highly dyn...
NAL1 forms a molecular cage to regulate FZP phase separation
NARROW LEAF 1 ( NAL1 ), originally identified for its role in shaping leaf morphology, plant architecture, and various agronomic traits in r...
Perturbing nuclear glycosylation in the mouse preimplantation embryo slows down embryonic development
The main form of intracellular protein glycosylation (O-GlcNAc) is reversible and has been mapped on thousands of cytoplasmic and nuclear proteins, including RNA polymerase II, transcription factors,...
Chemically active wetting
Wetting of liquid droplets on passive surfaces is ubiquitous in our daily lives, and the governing physical laws are well understood. When surfaces become active, however, the governing laws of wettin...
The importance of playing the long game when it comes to pandemic surveillance
Two transcription factors play critical roles in mediating epigenetic regulation of fruit ripening in tomato
DNA methylation regulates fruit ripening in tomato, and disruption of the DNA demethylase DEMETER-LIKE 2 (DML2) results in genome-wide DNA hypermethylation and impaired ripening. We report here that t...
Evolutionary divergent kinetoplast genome structure and RNA editing patterns in the trypanosomatid <i>Vickermania</i>
The trypanosomatid flagellates possess in their single mitochondrion a highly complex kinetoplast (k)DNA, which is composed of interlocked circular molecules of two types. Dozens of maxicircles repres...
Indigenous Knowledge as a sole data source in habitat selection functions
While Indigenous Knowledge (IK) contains a wealth of information on the behavior and habitat use of species, it is rarely included in the species–habitat models frequently used by Western species mana...