Proceedings of the National Academy of Sciences
Articles in this Issue
Differentiated planetesimals record differing sources of sulfur in inner and outer solar system materials
The isotope anomalies of noncarbonaceous (NC) and carbonaceous (CC) extraterrestrial materials provide a framework for tracing the distribution and accretion of matter in the early solar system. Here,...
Induced B cell receptor diversity predicts PD-1 blockade immunotherapy response
Immune checkpoint inhibitors such as anti-Programmed Death-1 antibodies (aPD-1) can be effective in treating advanced cancers. However, many patients do not respond, and the mechanisms underlying thes...
Bayesian phylodynamic inference of population dynamics with dormancy
Many organisms employ reversible dormancy, or seedbank, in response to environmental fluctuations. This life-history strategy alters fundamental ecoevolutionary forces, leading to distinct patterns of...
Multiscale biased chemical space remodeling for developing APLNR agonists with anti-HFpEF efficacy
Heart failure with preserved ejection fraction (HFpEF) represents a significant global health burden, yet effective pharmacotherapies remain elusive. The angiotensin-like 1 receptor, also known as the...
Massive mutagenesis reveals an incomplete amyloid motif in Bri2 that turns amyloidogenic upon C-terminal extension
Stop-loss mutations cause over twenty different diseases. The effects of stop-loss mutations can have multiple consequences that are, however, hard to predict. Stop-loss in ITM2B/B...
Stereoselective construction of coconformational mechanically helical and topologically chiral [2]catenanes induced by point chirality
Supported by chiral stationary phase high-performance liquid chromatography HPLC (CSP-HPLC), examples of chiral mechanically interlocked organic molecules, including knots, rotaxanes, and catenanes, h...
Total whole-arm chromosome losses predict malignancy in human cancer
Aneuploidy is observed as gains or losses of whole chromosomes or chromosome arms and is a common hallmark of cancer. Whereas models for the generation of aneuploidy in cancer invoke mitotic chromosom...
Metasurface-assisted multimodal quantum imaging
Traditional quantum imaging is featured by remarkable sensitivity and signal-to-noise ratio, but limited by bulkiness and static function (either phase contrast imaging or edge detection). Our report...
Testing theories of political persuasion using AI
Despite its importance to society and many decades of research, key questions about the social and psychological processes of political persuasion remain unanswered, often due to data limitations. We...
Micromechanical modeling of triphasic granular media
This paper presents pore unit assembly-discrete element model (PUA-DEM), a pore-scale hydromechanical framework that resolves interactions between mobile granular particles and multiphase fluids in un...
Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis
Metabolic dysfunction–associated steatohepatitis (MASH) represents a progressive form of steatotic liver disease which increases the risk for fibrosis and advanced liver disease. The accumulation of d...
Divergence in children’s gender stereotypes and motivation across STEM fields
STEM disciplines are traditionally stereotyped as being for men and boys. However, in two preregistered studies of Grades 1 to 12 students in the United States ( N...
The diffused evolutionary dynamics of morphological novelty
Rates of evolution are fundamental to understand the processes that shaped the history of life. The predominant view holds that high rates of phenotypic evolution result from lineage transitions acros...
Antiviral resistance and barrier integrity at the maternal-fetal interface restrict hepatitis E virus from crossing the placental barrier
Hepatitis E virus (HEV) genotype 1 (HEV-1) infection in pregnant women is associated with adverse outcomes of pregnancy including fulminant hepatic failure, fetal loss, premature birth, and neonatal m...
Long-term tree population growth can predict woody encroachment patterns
Recent increases in woody plant density in dryland ecosystems—or “woody encroachment”—around the world are often attributed to land-use changes such as increased livestock grazing and wildfire suppres...
A responsive living material prepared by diffusion reveals extracellular enzyme activity of cyanobacteria
Stimuli-responsive engineered living materials (ELMs) can respond to environmental or biochemical cues and have broad utility in biological sensors and machines, but have traditionally been limited to...
Global modulation of gene expression and transcriptome size in aneuploid combinations of maize
Genomic imbalance refers to the more severe phenotypic consequences of changing a single chromosome compared to changing the whole genomic set. Previous genomic imbalance studies in maize have identif...
Detecting DNA translocation through a nanopore using a van der Waals heterojunction diode
A long-unrealized goal in solid-state nanopore sensing is to achieve out-of-plane electrical sensing and control of DNA during translocation, which is a prerequisite for base-by-base ratcheting that e...
Psychological reactance to system-level policies before and after their implementation
Governments need to develop and implement effective policies to address pressing societal problems of our time, such as climate change and global pandemics. While some policies focus on changing indiv...
Next-generation rifamycins for the treatment of mycobacterial infections
Mycobacterium abscessus is a rapidly growing nontuberculous Mycobacterium causing severe pulmonary infections, especially in immunocompromis...
Retraction for Duckworth et al., Role of test motivation in intelligence testing
Synthesized dispersion-engineered elastic metasurfaces for achromatic focusing and harvesting across the audible to ultrasound ranges
Metasurfaces have garnered significant attention for unnatural abilities to modulate waves across various physics domains, including elastics. However, existing elastic metasurfaces are limited to nar...
Historians use data science to mine the past
Diane E. Griffin, physician–scientist extraordinaire
In October 2024, the scientific world lost Diane E. Griffin, a highly accomplished physician–scientist who greatly heightened our understanding of viral pathogenesis. Apart from being a leading virolo...
Quantification and potential functional relevance of binding cooperativity of adjacent transcription factors on DNA
In eukaryotes, the expression of specific genes is regulated by a combination of transcription factors (TFs) bound on regulatory regions of the genomic DNA (promoters and enhancers). Recent advances i...