Proceedings of the National Academy of Sciences
Articles in this Issue
Persistent inequalities in global air quality monitoring should not delay pollution mitigation
Air pollution is a global health crisis that disproportionately affects lower- and middle-income countries. We examine global air quality monitoring data, highlighting persistent inequalities in high-...
Dissociation of SYNGAP1 enzymatic and structural roles: Intrinsic excitability and seizure susceptibility
SYNGAP1 is a key Ras-GAP protein enriched at excitatory synapses, with mutations causing intellectual disability and epilepsy in humans. Recent studies have revealed that in addition to its role as a...
Challenges to sustainable large-scale shale gas development in China
China’s shale gas production has grown annually by 21% since 2017 with long-term national energy strategy calling for continued expansion. This large-scale shale gas development is challenged by const...
Dysregulation of MYBL2 impairs extravillous trophoblast lineage development and function, contributing to recurrent spontaneous abortion
Recurrent spontaneous abortion (RSA) is a pregnancy-related condition characterized by a complex etiology. While placental trophoblast dysfunction is strongly associated with the development and progr...
Possible evidence of excitonic condensation in a topological insulator
The transient excitonic condensate is a nonequilibrium electron–hole Bardeen–Cooper–Schrieffer state in a photoexcited semiconductor and semimetal, where electron–hole pairs undergo a phase transition...
Twinfilin is a nonprocessive depolymerase which synergizes with formin to dramatically accelerate actin filament uncapping by 300-fold
For over four decades, our understanding of cellular actin dynamics has been guided by the concept of treadmilling. However, this paradigm has been challenged by the evidence that twinfilin can uncap...
A symbiotic gene stimulates aggressive behavior favoring the survival of parasitized caterpillars
Animals often exhibit increased aggression in response to starvation, while parasites often manipulate host behavior. In contrast, underlying molecular mechanisms for these behavioral changes are most...
Dopamine induces fear extinction by activating the reward-responding amygdala neurons
The extinction of conditioned fear responses is crucial for adaptive behavior, and its impairment is a hallmark of anxiety disorders such as posttraumatic stress disorder. Fear extinction takes place...