Proceedings of the National Academy of Sciences
Articles in this Issue
Including the gender dimension of migration is essential to avoid systematic bias in migration predictions
This study examines the theoretical and methodological limitations of migration research in understanding gender-specific trends of migration. In particular, theory-driven methods suffer from the gend...
Controlling T cell–tumor cell interaction with a biomimetic physical barrier for cancer immunotherapy
Cancer immunotherapy has shown tremendous promise in various cancers. However, current strategies, such as immune checkpoint blockade, primarily restore exhausted T cells but provide only transient ef...
Multiarea processing in body patches of the primate inferotemporal cortex implements inverse graphics
Stimulus-driven, multiarea processing in the inferotemporal (IT) cortex is thought to be critical for transforming sensory inputs into useful representations of the world. What are the formats of thes...
The WWP1–JARID1B axis sustains acute myeloid leukemia chemoresistance
To uncover substrates mediating the oncogenic activity of WWP1 in acute myeloid leukemia (AML), we performed a proteomic analysis that identified the histone demethylase KDM5B...
Unveiling the charge transport blockade in the D2 branch of the photosystem II reaction center
Photosynthesis, the fundamental process sustaining life on Earth, depends on the photosystem II (PSII) reaction center’s ability to initiate the charge transport process. In this study, we have invest...
Revealing the structure of snowflakes using acoustic levitation
CDKN1B (p27/kip1) enhances drug-tolerant persister CTCs by restricting polyploidy following mitotic inhibitors
The mitotic inhibitor docetaxel (DTX) is often used to treat endocrine-refractory metastatic breast cancer, but initial responses are mitigated as patients develop disease progression. Using a cohort...
DNA2 protein destruction dictates DNA hyperexcision, cGAS–STING activation, and innate immune response in CDK12-deregulated cancers
CDK12 primarily functions as a transcription regulatory cyclin-dependent kinase (CDK) that controls mRNA elongation, splicing, and polyadenylation. The CDK12 ge...
Subterranean salamanders lean into mechanical sense following vision loss
AI-driven design of multiprincipal element alloys for optimal water splitting
Water splitting for hydrogen production is essential in advancing the hydrogen economy. Multiprincipal element alloys offer promising opportunities for optimizing this process, yet their vast composit...
GSK3β phosphorylated tau filaments are probably not like those from AD brains
p63 and ZNF148 cooperate to regulate head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is a common and aggressive malignancy. While significant advances have been made in the management of low-grade cancer, treatment of advanced HNSCC remain...
Correction to Supporting Information for Kim et al., Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition
Environmental variability shapes the representational format of cultural learning
Cumulative culture requires learning mechanisms that are both efficient and flexible in the face of environmental change. We examine models of this learning mechanism that emphasize teaching what to d...
An aminosterol breaks the autocatalytic cycle of Aβ <sub>42</sub> aggregation and protects cell membranes from its soluble aggregates
Aberrant aggregates of the 42-residue form of the amyloid-β peptide (Aβ 42 ) are cytotoxic in Alzheimer’s disease (AD). Cost-effective and chronically safe dise...
Ancient forests help document the long-term impacts of climate change
Chlorophyll trends are negative for lakes but positive for estuarine–coastal waters
Nutrient (nitrogen and phosphorus) pollution is an environmental problem of global concern because overenrichment of water bodies increases phytoplankton biomass and ecosystem metabolism, depletes oxy...
Inherent instability leads to high costs of hovering in near-neutrally buoyant fishes
Hovering, the ability to maintain a stationary position in fluid, is essential for many fish species during prey capture, habitat exploration, and mating. While traditionally assumed to be energetical...
The evolution of male–female dominance relations in primate societies
Historically, it was widely assumed that males dominate females socially in most mammals. However, recent studies revealed significant variation within and among species, opening new possibilities to...
Osteoinductive low-dose 3D porous calcium phosphate graphene oxide–integrated matrices enhance osteogenesis and mechanical properties
Bone regeneration continues to be a challenge due to the complex nature of the tissue. Identifying new materials that stimulate regeneration while providing mechanical properties is an active area of...
Cell-to-cell translocation of florigen is inhibited by low ambient temperature through abscisic acid signaling in <i>Arabidopsis thaliana</i>
In Arabidopsis thaliana , the FLOWERING LOCUS T ( FT ) gene encodes florigen, a...
Hippocampal blood oxygenation predicts choices about everyday consumer experiences: A deep-learning approach
This research investigates the neurophysiological mechanisms of experiential versus monetary choices under risk. While ventral striatum and insula activity are instrumental in predicting monetary choi...
Adaptive arousal regulation: Pharmacologically shifting the peak of the Yerkes–Dodson curve by catecholaminergic enhancement of arousal
Performance typically peaks at moderate arousal levels, consistent with the Yerkes–Dodson law, as confirmed by recent human and mouse pupillometry studies. Arousal states are influenced by neuromodula...
What you C is what you get
Declining winter snowpack offsets carbon storage enhancement from growing season warming in northern temperate forest ecosystems
Northeastern US temperate forests are currently net carbon (C) sinks and play an important role offsetting anthropogenic C emissions, but projected climatic changes, including increased temperatures a...