Proceedings of the National Academy of Sciences
Articles in this Issue
Confinement of ions within graphene oxide membranes enables neuromorphic artificial gustation
Introducing neuromorphic computing paradigms into taste-sensing technology will bring unprecedented opportunities for developing new hardware architectures with perceptual intelligence. Constructing t...
Autophagic stress activates distinct compensatory secretory pathways in neurons
Autophagic dysfunction is a hallmark of neurodegenerative disease, leaving neurons vulnerable to the accumulation of damaged organelles and aggregated proteins. However, the late onset of diseases sug...
Common inherited loss-of-function mutations in the innate sensor NOD2 contribute to exceptional immune response to cancer immunotherapy
Lung cancers and melanomas have many somatically mutated self-proteins that would be expected to trigger an immune rejection response, yet therapeutic responses can only be induced in a subset of pati...
Human milk IgA promotes normal immune development by limiting Th17-inducing <i>Erysipelatoclostridium ramosum</i> in the infant gut
The gut microbiota is highly dynamic during the first year of life and plays a crucial role in immune development. Breastfeeding is known to support infant health, but the contributions of the numerou...
Structure-based discovery of positive allosteric modulators of the A <sub>1</sub> adenosine receptor
Allosteric modulation of G protein–coupled receptors (GPCRs) is an exciting strategy for developing new therapeutic agents, and it has several advantages over more commonly used orthosteric drugs. Rec...
Acyl-CoA-binding protein as a driver of pathological aging
The tissue hormone acyl coenzyme A–binding protein (ACBP, encoded by the gene diazepam-binding inhibitor , DBI) has been implicated in various facets of patholo...
Decoding and engineering temperature-sensitive lethality in <i>Ceratitis capitata</i> for pest control
The Sterile Insect Technique (SIT) is a species-specific and environmentally friendly method for effectively controlling pest insect populations based on releasing reared, sterile insects into infeste...
Reply to Dablander et al.: Identifying interventions that change intentions lays a valuable foundation for behavior change
Expressing intentions is not climate action
Reply to Pang et al.: Generalizable ability to track beliefs could be the most parsimonious explanation
Do large language models have a theory of mind?
Herbarium specimens reveal a constrained seasonal climate niche despite diverged annual climates across a wildflower clade
Quantifying species’ niches across a clade reveals how environmental tolerances evolve, and offers insights into present and future distributions. We use herbarium specimens to explore climate niche e...
Genetic ancestry shapes dengue virus infection in human skin explants
Dengue is the most prevalent arthropod-borne viral disease of humans, with over half the world’s population at risk. Infection with any of the four dengue virus (DENV) serotypes is most often self-lim...
Genome analyses suggest recent speciation and postglacial isolation in the Norwegian lemming
The Norwegian lemming ( Lemmus lemmus ) is a small rodent distributed across the Fennoscandian mountain tundra and the Kola Peninsula. The Norwegian lemming lik...