Proceedings of the National Academy of Sciences
Articles in this Issue
The apportionment of dietary diversity in wildlife
Evaluating species’ roles in food webs is critical for advancing ecological theories on competition, coexistence, and biodiversity but is complicated by pronounced dietary variability within species a...
Targeting PBK with small-molecule 1- <i>O</i> -acetyl-4 <i>R</i> ,6 <i>S</i> -britannilactone for the treatment of neuroinflammation
Neuroinflammation is a complex immunological phenomenon characterized by a dysregulated inflammatory response in the central nervous system (CNS) that can be triggered by various pathological injuries...
Different folding mechanisms in prion proteins from mammals with different disease susceptibility observed at the single-molecule level
Misfolding of the protein PrP causes prion diseases in mammals. Disease susceptibility varies widely among species, despite PrP sequences differing by only a few amino acids. How these differences alt...
The intensification of the strongest nor’easters
Nor’easters are coastal extratropical cyclones that feed upon both thermal contrasts (meridional and land-ocean) and oceanic latent heat release, causing them to intensify along the U.S. East Coast. W...
A fire-safe Li metal battery via smart gas management
Lithium (Li) metal batteries offer high energy density but face significant safety challenges due to gas evolution under thermal abuse conditions. At the anode, the reduction of organic carbonate-base...
Decoding nature’s grammar with DNA language models
De novo design of a fusion protein tool for GPCR research
G protein–coupled receptors (GPCRs) play pivotal roles in cellular signaling and represent prominent drug targets. Structural elucidation of GPCRs is crucial for drug discovery efforts. However, struc...
Inter- and transdisciplinary knowledge is critical for nature-based solutions to contribute to just urban transformations
Nature-based solutions (NBS) are used to transform existing unsustainable and undesirable path dependencies in cities. For NBS to contribute to just urban transformations, a stronger inter- and transd...
Glycolipids implicated as mediators of clinically visible retinal pigment epithelial migration in age-related macular degeneration
The retinal pigment epithelium (RPE) is the metabolic gatekeeper to the photoreceptors, thus playing many essential roles in healthy vision. Under certain conditions, RPE cells may transdifferentiate...
Microscopic and structural observations of actin filament capping and severing by cytochalasin D
Cytochalasin D (CytoD), a widely used actin inhibitor, is typically employed in cell studies as a simple barbed end capper. However, accumulating evidence suggests broader effects on actin dynamics. W...
QnAs with Hans F. Coetzee
Unusual bone bed reveals a vertebrate community with pterosaurs and turtles in equatorial Pangaea before the end-Triassic extinction
Temporally constrained microvertebrate bone beds are powerful tools for understanding continent-scale biotic change. Such sites are rare globally in nonmarine settings during the 12 million years (Ma)...