Proceedings of the National Academy of Sciences
Articles in this Issue
Ciprofloxacin-driven purifying selection on viral genomes accelerates soil N <sub>2</sub> O production
Viruses are ubiquitous regulators of microbial dynamics and may thus greatly influence global microbial-driven greenhouse gas emissions. Anthropogenic stressors, such as chemical contamination, are li...
Training and retraining liquid crystal elastomer metamaterials for pluripotent functionality
Training has emerged as a promising materials design technique in which function can be achieved through repeated physical modification of an existing material rather than by direct chemical functiona...
Representational drift and learning-induced stabilization in the piriform cortex
The brain encodes external stimuli through patterns of neural activity, forming internal representations of the world. Increasing experimental evidence showed that neural representations for a specifi...
Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo
Lipid nanoparticles (LNP) represent a versatile platform for improving delivery of therapeutic nucleic acids. Yet, delivery to the myocardium remains a formidable challenge due to local barriers in th...
α-glucan remodeling by GH13-domain enzymes shapes fungal cell wall architecture
Cell walls are critical structures of fungi, bacteria, and plants, providing mechanical strength, maintaining shape, and protecting cells from environmental stress. In the fission yeast...
Unveiling organ-specific metabolism of <i>Citrus clementina</i>
Understanding plant response to environmental factors such as temperature, drought, diseases, and carbon-to-nitrogen (C:N) ratio is essential for crop resilience, quality, and adaptation to climate ch...
Correction Carozza et al., Whole-brain white matter variation across childhood environments
ADPact: A versatile sensor for ADP-F-actin
The dynamic organization of the actin cytoskeleton, crucial for numerous cellular processes, is intricately regulated by the nucleotide state of actin filaments (F-actin). Visualization tools for spec...
Diverse and dynamic influences of saccades on visual representations in the mouse superior colliculus
How do sensory systems account for stimuli generated by natural behavior? We addressed this question by examining how an ethologically relevant class of saccades modulates visual representations in th...
A versatile immunomodulated nanoCRISPR converter augments the susceptibility and visibility of tumors to the immune system
Immune checkpoint blockade (ICB) has potential in alleviating cytotoxic T lymphocyte (CTL) exhaustion. However, resistance that impaired major histocompatibility complex class I (MHC-I) expression on...
A population genetic analysis of the nematode <i>Strongyloides stercoralis</i> in Asia shows that human infection is not a zoonosis from dogs
Gut nematode worms are important parasites of people and other animals. The parasitic nematode Strongyloides stercoralis infects an estimated 600 million people...
NEDD4L induces mitochondrial dysfunction and neurodegeneration by promoting LIPT2 degradation in Huntington’s disease
Impairment of mitochondrial protein stability is associated with neurodegeneration in Huntington’s disease (HD). However, the E3 ligase responsible for maintaining mitochondrial protein homeostasis in...
A gentle palette of plasma membrane dyes
Plasma membrane (PM) stains are important organelle markers for monitoring membrane morphology and dynamics. The state-of-the-art PM stains are bright, specific, fluorogenic, and compatible with super...
Foxn3 is required to suppress aberrant ciliogenesis in nonphotoreceptor retinal neurons
The retinal photoreceptors possess specialized sensory cilia critical for phototransduction while the nonphotoreceptor cells typically exhibit simpler primary cilia or lack them altogether. This dicho...
Classical BSE emergence from Nor98/atypical scrapie: Unraveling the shift vs. selection dichotomy in the prion field
Prion diseases can manifest with distinct phenotypes in a single species, a phenomenon known as prion strains. Upon cross-species transmission, alterations in the disease phenotype can occur, interpre...
Elevated CO <sub>2</sub> alters relative belowground carbon investment for nutrient acquisition in a mature temperate forest
Forests are potential carbon (C) sinks that partially offset anthropogenic carbon dioxide (CO 2 ) emissions via enhanced C assimilation and productivity. Howeve...
Dynamic forces drive cell and organ morphology changes during embryonic development
Cells, tissues, and organs must change shape in precise ways during embryonic development to execute their functions. Multiple mechanisms including biochemical signaling pathways and biophysical force...
A quantitative imaging framework for lithium morphology: Linking deposition uniformity to cycle stability in lithium metal batteries
Characterizing the morphology of lithium (Li) is crucial for developing long-lasting lithium metal batteries. It is well established that more uniform Li deposition correlates with better cell perform...
Paleobiome dynamics shaped a large Gondwanan plant radiation
Theories of adaptive radiation propose predictable trajectories in which diversity accumulates rapidly in newly formed or colonized environments with underexploited niche space and few competing speci...
Structural basis of the inhibition of TRPV1 by analgesic sesquiterpenes
The Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel is expressed in primary nociceptive afferents, which participate in processes such as pain and inflammation. Considerable efforts have...
Inference of human pigmentation from ancient DNA by genotype likelihoods
Light eyes, hair, and skins probably evolved several times as Homo sapiens dispersed from Africa. In areas with lower UV radiation, light pigmentation alleles i...
A genetically defined pontine nucleus essential for ingestion in mice
The first phase of feeding consists in the procurement of solid foods from the environment by biting, and their preparation for swallowing by chewing. These actions require the precise coordination of...
Mutualisms within light microhabitats are associated with sensory convergence in a mimetic butterfly community
Niche partitioning within variable habitats can expose species to distinct sensory information. Vision is the primary sensory modality used by many animals to interact with their habitat. However, the...
Climate-linked biogeography of mycorrhizal fungal spore traits
Climate-driven variation in traits is crucial for predicting ecological responses to environmental change, yet global patterns and drivers of microbial trait variation remain poorly understood. Using...
Complementary genetic and epigenetic changes facilitate rapid adaptation to multiple global change stressors
To persist under unprecedented rates of global change, populations can adapt or acclimate. However, how these resilience mechanisms interact, particularly the role of epigenetic variation in long-term...