Proceedings of the National Academy of Sciences
Articles in this Issue
The power of bridging decision scales: Model coupling for advanced climate policy analysis
Climate policy faces increasingly complex challenges that span multiple human decision scales in nature–society systems. Contemporary climate policy models, while valuable and increasingly versatile i...
Peritumoral macrophages recruit eosinophils to promote antitumor immune responses in breast cancer
Breast tumors harbor dynamic microenvironments, with multiple immune cell types playing opposing roles during tumor progression and/or response to therapy. Tumor-associated macrophages promote mammary...
More 26S and 30S proteasomes are beneficial in proteinopathy
Despite the many studies on the ubiquitin–proteasome system, our understanding of the proteasome itself is limited. The balance and regulation of 26S and 30S proteasomes are not yet known. Here, we sh...
Intron 1 of the <i>C9orf72</i> gene: The RNA that RAN
An in vitro BRAF activation assay elucidates molecular mechanisms driving disassembly of the autoinhibited BRAF state
The RAF kinases (ARAF, BRAF, and CRAF) are essential components of the RAS-ERK signaling pathway, which controls vital cellular processes and is frequently dysregulated in human disease. Notably, muta...
Reply to Possenriede et al.: LDLR as a targetable HlyA receptor in <i>Escherichia coli</i> pyelonephritis
Weighted active space protocol for multireference machine-learned potentials
Multireference methods such as multiconfiguration pair-density functional theory accurately capture electronic correlation in systems with strong multiconfigurational character, but their cost preclud...
Tropical cyclones expand faster at warmer relative sea surface temperature
Tropical cyclones are expected to intensify more rapidly with warming, but relatively little work has examined whether they could expand more rapidly with warming, too. Recent theory predicts that pea...
Did the vilca/tobacco snuff combination at Chavín aim for an “ayahuasca effect”?
The cost of banning TikTok: Implications for the digital advertising market
Social media platforms have become vital channels for businesses to reach consumers through advertising. But in the United States, the digital advertising market in which these platforms operate is do...
Parametrically guided design of beta barrels and transmembrane nanopores using deep learning
Francis Crick’s global parameterization of coiled coil geometry has been widely useful for guiding design of new protein structures and functions. However, design guided by similar global parameteriza...
A reanalysis of population dynamics in the Casas Grandes region of Northern Mexico using mitochondrial DNA
The Casas Grandes region in northwest Chihuahua, Mexico, is ideally situated to explore the notion of contact between the US Southwest/Northwest Mexico and Mesoamerica, as it lies geographically in a...
Reply to Quillien: Intuitive preferences and interpretive humility in intentionality judgments
Tubular ACSM3 deficiency impairs medium-chain fatty acid metabolism and aggravates kidney fibrosis
Kidney fibrosis is driven by multiple factors, among which impaired fatty acid oxidation has emerged as a critical determinant. Acyl-Coenzyme A (CoA) synthetase medium-chain family member 3 (ACSM3), a...
Earliest evidence of smoke-dried mummification: More than 10,000 years ago in southern China and Southeast Asia
In southern China and Southeast Asia (collectively, Southeastern Asia), Terminal Pleistocene and Early to Middle Holocene (ca. 12,000 to 4,000 cal. BP) hunter-gatherer burials feature tightly crouched...
LDL receptor promotes urinary tract infection by α-hemolysin-producing <i>Escherichia coli</i> and long-term histopathologic sequelae in the kidney
Wnt inhibition alleviates resistance to anti-PD1 therapy and improves antitumor immunity in glioblastoma
Wnt signaling plays a crucial role for many developmental processes. It is also pivotal in the generation and limited treatment outcomes of glioblastoma (GBM). Here, we identified Wnt7b, which is mark...
A solid-state battery capable of 180 C superfast charging and 100% energy retention at –30 °C
Solid-state electrolytes (SSEs) are being extensively researched as replacements for liquid electrolytes in future batteries. Despite significant advancements, there are still challenges in using SSEs...