Proceedings of the National Academy of Sciences
Articles in this Issue
High-magnetic-field phases in U <sub>1-x</sub> Th <sub>x</sub> Te <sub>2</sub>
At temperatures T much lower than its superconducting critical temperature T c = 2.1 K, the heavy fe...
Medicine on the menu: When illness informs appetite
Guardians at the border: Peritumoral macrophages fight breast cancer
Sex differences in healthy brain aging are unlikely to explain higher Alzheimer’s disease prevalence in women
As Alzheimer’s disease (AD) is diagnosed more frequently in women, understanding the role of sex has become a key priority in AD research. However, despite aging being the primary risk factor for AD,...
Synthetic bottlebrush block copolymer prevents disease onset in Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is a fatal genetic disease of progressive muscle deterioration with no cure. DMD treatment requires a body-wide approach to target all diseased striated muscles: limb...
Neural predictors of hidden, persistent psychological states at work
Common workplace challenges such as feeling overwhelmed, burned out, or disengaged often remain hidden due to fear of judgment or social norms, contributing to rising mental health crises and organiza...
Hydrothermal vent temperatures track magmatic inflation and forecast eruptions at the East Pacific Rise, 9°50’N
Hydrothermal vent temperatures fluctuate in response to transient magmatic and tectonic activity at the axis of mid-ocean ridges (MORs) and modulate energy fluxes from the deep Earth to the ocean. Suc...
Post-reproductive lifespan in wild mountain gorillas
Animals can typically maximize their fitness by reproducing throughout adulthood. Yet, in a handful of species, females cease reproduction long before death, highlighting an apparent evolutionary para...
Microbial oxidation significantly reduces methane export from global groundwaters
Methane is ubiquitous in groundwater, and its release to surface environments through pumping, discharge, or diffusion is an emerging environmental concern. Microbial oxidation consumes methane and mi...
Electrical and thermal conductivity of Earth’s iron-enriched basal magma ocean
The Earth’s earliest magnetic field may have originated in a basal magma ocean, a layer of silicate melt surrounding the core that could have persisted for billions of years. Recent studies show that...
Still no evidence for an environmentally responsive epigenetic clock in an insect
Temperature adaptation in structure and function in lactate dehydrogenase-A reflects convergent evolution in a few key protein regions
Adaptive differences in the thermal stabilities of enzyme structure and function play critical roles in establishing the thermal optima and limits of all organisms. Thus, understanding the mechanisms...
Scaling laboratory results with machine learning is no silver bullet to strengthen global (micro)plastic mitigation policy
Reply to Maleszka et al.: DNA methylation signals persist across insect metamorphosis
Reply to Brandes et al.: A first step, not a final word, on modeling microplastics-induced crop losses
Droplet outbursts from onion cutting
Cutting onions often leads to tear-inducing aerosol release, yet the underlying mechanics remain poorly understood. In this work, via high-speed characterizations, we show that droplet formation occur...
Modeling the rise and demise of Classic Maya cities: Climate, conflict, and economies of scale
Urbanization was one of the most significant transitions in human history, yet explanations for the rise and expansion of early cities remain contentious. Here, we propose that simple models from popu...
Phylogenomics redefines the evolutionary history of mosquitoes
Mosquitoes have a substantial impact on human and animal health, but their deeper evolutionary relationships have been difficult to resolve. We inferred a time-calibrated phylogenetic history of mosqu...
Reconfiguration of brain-wide neural activity after early life adversity
Early life adversity (ELA) predisposes individuals to physical and mental disorders lifelong. How ELA affects brain functions, leading to these vulnerabilities, is a mystery. To understand ELA’s impac...
Engineered 3D immuno-glial-neurovascular human miBrain model
Patient-specific, human-based cellular models integrating a biomimetic blood–brain barrier, immune, and myelinated neuron components are critically needed to enable accelerated, translationally releva...
Bridging microscopic dynamics and rheology in the yielding of charged colloidal suspensions
The yielding of soft materials is critical to many natural and industrial processes, yet experimental insights into microscopic aspects of yielding are limited. This study combines angle X-ray scatter...
Forest recovery after deforestation is fueled by mineral weathering at the expense of ecosystem buffering capacity
The pace and trajectory of ecosystem development are governed by the availability and cycling of limiting nutrients, and anthropogenic disturbances such as acid rain and deforestation alter these traj...
Anomalous grain dynamics and grain locomotion of odd crystals
Crystalline or polycrystalline systems governed by odd elastic responses are known to exhibit complex dynamical behaviors involving self-propelled dynamics of topological defects with spontaneous self...
The persistence of cross-cutting discussion in a politicized public sphere
Although studies of Americans’ general discussant networks have been repeated over time, research that assesses change in the nature of Americans’ political dis...
Hierarchical dynamic coding coordinates speech comprehension in the human brain
Speech comprehension involves transforming an acoustic waveform into meaning. To do so, the human brain generates a hierarchy of features that converts the sensory input into increasingly abstract lan...