Proceedings of the National Academy of Sciences
Articles in this Issue
Iron limitation differentially affects viral replication in key marine microbes
Viral lysis accounts for much of microbial mortality in the ocean, and iron (Fe) is a critical micronutrient that can limit phytoplankton growth. However, interactions between Fe nutrition of microbes...
Global conformation of the Rag GTPase heterodimer governs eukaryotic amino acid sensing
The Rag GTPase heterodimer is a central mediator of amino acid sensing in eukaryotic cells. When amino acids are abundant, it binds to the mechanistic target of rapamycin complex 1 to activate cellula...
Profile of Jean-Philippe Avouac
Jean-Philippe Avouac, elected to the National Academy of Sciences in 2025, explores deformations in Earth’s surface in an effort to understand the formation and behavior of earthquakes. Using geology,...
Correction for Bassiouni et al., Observed declines in leaf nitrogen explained by photosynthetic acclimation to CO <sub>2</sub>
Substrate-dependent activation of LONP1 informs on proteolytic regulation and ATPase motor function
AAA+ enzymes use energy from ATP hydrolysis to remodel diverse cellular targets. Structures of substrate-bound AAA+ complexes suggest that these enzymes employ a conserved hand-over-hand mechanism to...
In the wake of wildfires, toxic smoke is a lasting health concern
Correction for Bonetti et al., Decoding the elite soccer player’s psychological profile
Mitotic recombination events and single-base mutations induced by ultraviolet light in G1-arrested yeast cells
Ultraviolet light (UV) is a potent inducer of both single-base mutations and mitotic recombination. Although these genomic alterations are often attributed to the action of error-prone DNA polymerases...