Proceedings of the National Academy of Sciences
Articles in this Issue
Male-derived PBP4 is essential for sperm competition by mediating sperm motility in moths
Male moths rely on antennal olfactory sensilla to detect female-emitted sex pheromones during mate localization, a process critically mediated by pheromone-binding proteins (PBPs) that facilitate liga...
Serum response factor is essential for endometrial function and prevention of inflammatory fibrosis
Pregnancy requires a supportive uterine environment facilitated by steroid hormone–regulated differentiation of endometrial stromal fibroblasts into decidual cells and tight control of inflammation. S...
Structural pores not required: Antimicrobial peptides induce ion permeabilization of lipid membranes through transient water channels
Antimicrobial peptides (AMPs) are highly potent and broad-spectrum antibiotics, found as components of the innate immune system in almost all forms of life. Despite being commonly accepted that the me...
Homology-mediated transformation of frog-killing fungus <i>Batrachochytrium dendrobatidis</i> illuminates chytrid development and pathogenesis
The chytrid fungus Batrachochytrium dendrobatidis ( Bd ) infects amphibians and causes chytridiomycosis, a disease linke...
A functional clock in only two dorsal clock neurons is sufficient to restore the basal circadian activity pattern of <i>Drosophila melanogaster</i>
Circadian clocks form complex networks to orchestrate the behavior and physiology of animals. Elucidating the organization of these clock networks is critical to understanding how circadian clocks ach...
Micro-offline gains do not reflect offline learning during early motor skill acquisition in humans
While practicing a new motor skill, resting for a few seconds can improve performance immediately after the rest. This improvement, referred to as “micro-offline gains” (MOGs), has been interpreted as...
Miocene and Pliocene ice and air from the Allan Hills blue ice area, East Antarctica
Antarctic ice cores provide a unique archive of Earth’s atmosphere and its largest extant ice sheet. The oldest continuous ice core extends back 800 ky, though discontinuous ice cores from the Allan H...
Quantitative MRI of the hippocampus reveals microstructural trajectories of aging and Alzheimer’s disease pathology
Hippocampal degeneration is a feature of both normal aging and Alzheimer’s disease (AD). Prior to macroscopic degeneration, microstructural changes occur such as demyelination, iron deposition, or sub...
Mineralized sclerites in the gorgonian coral <i>Leptogorgia chilensis</i> as a natural jamming system
The soft corals (Cnidaria, Octocorallia), a diverse group of colonial marine invertebrates, can reversibly tune their body stiffness in response to external stimuli. This capability is attributed to t...
FibrilPaint to determine the length of Tau amyloids in fluids
Tau aggregation into amyloid fibrils is linked to the development of neurodegenerative diseases, including Alzheimer’s disease (AD). The molecular processes driving aggregation in disease are still be...
Keeping Wnt in check for efficient checkpoint blockade in glioblastoma
Global impact of anthropogenic NH <sub>3</sub> emissions on upper tropospheric aerosol formation
Anthropogenic ammonia (NH 3 ) emissions have significantly increased in recent decades due to enhanced agricultural activities, contributing to global air pollu...
Shared cognitive biases influence numerical judgments in macaques and crows
Cognitive biases, which come from the shortcuts our brains use to make decisions, often lead people to misjudge sizes, amounts, or other magnitudes. However, it is still unclear how these biases evolv...
Regional postdeforestation weathering feedback drove diachronous C–S cycle perturbations during the end-Permian crisis
The Permian–Triassic (P-Tr) transition (~252 Ma) witnessed Earth’s most severe biocrisis, which has long been linked to Siberian Traps volcanism and associated environmental upheaval. Major perturbati...
The war of the worldviews
Inflammasome targeting for periodontitis prevention is sex dependent
Inflammasome initiates inflammation via the maturation of interleukin-1 beta (IL-1β). Periodontitis is a prevalent, male-biased disease characterized by inflammation-driven bone loss, yet the mechanis...
Decreased hippocampal neurite density in late-middle-aged adults following prenatal exposure to higher levels of maternal inflammation
In animal models, exposure to heightened maternal inflammation in utero is associated with altered offspring hippocampal development, including reduced dendritic arborization and density. However, the...
Confronting the inevitable: Harnessing technology to contain systemic scientific fraud
Science and sensitivity in the study of not having sex
Discarded cigarette butts as overlooked reservoirs and amplifiers of antibiotic resistance genes and pathogens in urban green spaces
Cigarette butts are widely discarded in urban green spaces, yet their microbial health risks remain poorly understood. In a nationwide survey across China, we investigated the presence, sources, healt...
Optimizing multifunctional fluorescent ligands for intracellular labeling
Enzyme-based self-labeling tags enable the covalent attachment of synthetic molecules to proteins inside living cells. A frontier of this field is designing cell-permeable multifunctional ligands that...
Conformational transitions enabling interkingdom transfer of effector multitudes
Reply to Singer: Strike paper mills at the root
Precise temporal dynamics of ripple events support order memory in human hippocampal–cortical circuits
Serial order memory, a key type of episodic representation, requires the encoding of map–like context information (interitem relationships) to facilitate recall. In rodent models, both spatial and non...
Geochronology of the Early Triassic based on coupled Bayesian zircon eruption age and Bayesian age–depth models
Precise and accurate geochronology is essential for reconstructing Earth’s history and coeval life evolution. The Early Triassic was a critical time interval following the greatest Phanerozoic mass ex...