Proceedings of the National Academy of Sciences
Articles in this Issue
Proximity to explosive synchronization determines network collapse and recovery trajectories in neural and economic crises
Complex systems such as the conscious brain and financial markets often operate near criticality, a regime that supports flexible and efficient function. When perturbed, however, rapid deviations from...
A natural allele of <i>PC08</i> lost in domestication contributes to soybean seed storage protein accumulation
Soybean serves as a critical source of plant-based protein for both livestock and human nutrition, making seed protein content a key agronomic trait. However, modern soybean cultivars exhibit reduced...
Correction for Mittal et al., Mechanisms underlying allosteric modulation of antiseizure medication binding to synaptic vesicle protein 2A (SV2A)
Metabolic adaptation of glucose-deprived macrophages involves partial gluconeogenesis
Macrophages are recruited to sites of infection contributing to the killing of bacteria, but also to malignant tumors, where they promote angiogenesis and suppress antitumor immune responses. The meta...
QnAs with Deborah K. Morrison
James A. Estes: An ecologist’s quest to understand nature
For five decades, Jim A. Estes studied sea otters in the Aleutian archipelago of Alaska, discovering how otters structured entire communities. By consuming sea urchins, otters released kelp from herbi...
Testing paradox may explain increased observed prevalence of bacterial STIs among MSM on HIV PrEP: A modeling study
HIV pre-exposure prophylaxis (PrEP) is transforming global HIV prevention, but its implementation coincides with observations of rising bacterial sexually transmitted infection (STI) rates among men w...
Can neuromorphic computing help reduce AI’s high energy cost?
Correction for Tapinova et al., Integrated Ising model with global inhibition for decision-making
Correction for Jarvis et al., The impact of air pollution on petcare utilization
Slower searching yields higher efficiency: A case study of taxi drivers
The movement patterns of animals while searching for food have been studied extensively in recent decades. However, although human search behavior has existed since the beginning of civilization, not...
Genomic and insulin-mediated control of metabolic homeostasis by the mosquito ecdysone-induced gene E93
Ecdysone-induced protein 93 (E93) is an adult specifier that governs insect pupal-adult conversion. It affects the reproductive transition in adult Aedes aegypti...
p53 regulates the expression of histone modifiers to restrict stemness and maintain differentiated luminal identity in breast cancer
Breast cancer is the leading cause of death in women under 50. The majority of breast cancers are estrogen receptor α-positive (ER+) and are commonly treated with hormonal therapies such as tamoxifen...
Correction for Zhu et al., Factors underlying a latitudinal gradient in the S/G lignin monomer ratio in natural poplar variants
Dibromocarbene addition to bicyclo[1.1.0]butanes: A facile route to substituted bicyclo[1.1.1]pentanes
Strained, multicyclic hydrocarbons are increasingly important structural motifs for drug discovery. In particular, substituted bicyclo[1.1.1]pentanes (BCPs) have risen to prominence as bioisosteres fo...
Dynamical constraints on the vertical structure of Jupiter’s polar cyclones
Jupiter’s poles feature striking polygons of cyclones that drift westward over time, a motion governed by β...
Shifting power asymmetries in scientific teams reveal China’s rising leadership in global science
China’s emergence as one of the world’s top producers of high-quality science raises critical questions about its trajectory toward achieving scientific leadership. Traditional methods for evaluating...
Chemical propulsion of hemozoin crystal motion in malaria parasites
Malaria parasites infect red blood cells where they digest host hemoglobin and release free heme inside a lysosome-like organelle called the food vacuole. To detoxify excess heme, parasites form hemoz...
Symbiotic solutions for colony nutrition: Conserved nitrogen recycling within the bacterial pouch of <i>Tetraponera</i> ants
While microbial symbioses are fundamental to the nutrition of many animal groups, current paradigms focus on symbiont functions at the host individual level. It remains unclear whether microbial symbi...
Accessing robust vaccine coformulation stability by single adjuvant detection on a microelectrode
A significant question in next generation vaccine development is: How long are coformulated products stable on the shelf? The recent review by the US Food and Drug Administration of a single, prefille...
ZDHHC11-mediated AXL palmitoylation promotes osimertinib resistance in non-small-cell lung cancer
Receptor tyrosine kinase pathway rewiring represents a fundamental mechanism underlying acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant non-small-cell lung cancer (NSCLC). While...
Modulating the microbiome as an approach to anticancer drug development
Recent studies have suggested that the commensal microbiome positively affects cancer prognosis and treatment outcomes. However, only a few strategies for regulating the microbiome composition have be...
Jumbo phage–mediated transduction of genomic islands
Bacteria acquire new genes by horizontal gene transfer, typically mediated by mobile genetic elements (MGEs). While plasmids, bacteriophages, and certain integrative and conjugative elements are well...
Extreme triple oxygen isotope fractionation in <i>Equisetum</i>
Triple oxygen isotope values of xylem water were measured along the length of smooth horsetail stems ( Equisetum laevigatum ). Extreme isotope enrichment is obs...
Monocyte-derived exosomal periostin driven by histone lactylation contributes to retinal neovascularization
Exosomes are signaling messengers facilitating intercellular communication by delivering molecular cargo. Here, we observed increased levels of exosomal periostin (POSTN) in the blood plasma of patien...