Proceedings of the National Academy of Sciences
Articles in this Issue
Instantaneous response and quantum geometry of insulators
We present the time-dependent Quantum Geometric Tensor (tQGT) as a comprehensive tool for capturing the geometric character of insulators observable within linear response. We show that tQGT describes...
Digital twins come to the life sciences
Reviewers are better equipped to detect fraud than editors
Numerical calculation finds the revised elastic field of an edge dislocation to be incorrect
Reply to Neveu and Neveu: Inference in an information-restricted environment
Neurofluid circulation changes during a focused attention style of mindfulness meditation
Neurofluids, including cerebrospinal fluid (CSF) and interstitial fluid, circulate through regulated central nervous system pathways to clear cerebral waste and support brain health, with elevated CSF...
Reconstructing Waddington’s landscape from data
The development of a zygote into a functional organism requires that this single progenitor cell gives rise to numerous distinct cell types. Attempts to exhaustively tabulate the interactions within d...
Deciphering precursor cell dynamics in esophageal preneoplasia via genetic barcoding and single-cell transcriptomics
Although histologically normal, esophageal preneoplastic cells harbor early genetic alterations and likely exhibit lineage plasticity. However, their origins and trajectories remain unclear. To addres...
Correction for Greenberg et al., Sex and age differences in “theory of mind” across 57 countries using the English version of the “Reading the Mind in the Eyes” Test
Structural insights into the role of eIF3 in translation mediated by the HCV IRES
The genomes of various RNA viruses and a subset of human genes contain structured RNA elements termed internal ribosomal entry sites (IRESs) to initiate translation in a cap-independent manner. The we...
Guiding esophagectomy with intraoperative NIR-II fluorescence video imaging and rapid computation
Preclinical shortwave infrared/near-infrared II (SWIR/NIR-II, 1,000 to 3,000 nm) fluorescence imaging has shown superior contrast, resolution, and penetration depth compared to traditional near-infrar...
Restoring institutional confidence in backsliding democracies: Evidence from Mexico
Declining confidence in public institutions afflicts many democracies, a trend apparently exacerbated by backsliding leaders. These are leaders who gradually undermine the institutions that sustain de...
Conscious awareness, sensory integration, and evidence accumulation in bodily self-perception
Conscious awareness refers to the subjective experience of perceiving, thinking, and feeling and the ability to report these experiences. These perceptions and thoughts are experienced as bound to an...
TGFBR2 coordinates the endometrial response to estrogen, regulating endometrial hyperplasia and fertility
Proper endometrial function is critical for establishing and maintaining healthy pregnancies, as well as preventing the pathogenesis of conditions such as endometrial hyperplasia and endometrial cance...
Machine learning enables de novo multiepitope design of <i>Plasmodium falciparum</i> circumsporozoite protein to target trimeric L9 antibody
Currently approved vaccines for the prevention of malaria provide only partial protection against disease due to high variability in the quality of induced antibodies. These vaccines present the unstr...
Torque-generating units of the bacterial flagellar motor are rotary motors
Escherichia coli swims using helical flagellar filaments driven at their base by a rotary motor. Torque-generating “stator” units drive the bacterial flagellar motor by transmittin...
Correction for Yuan et al., Oil–water interfaces drive gold precipitation via microdroplet chemistry in thermal geological systems
Oxidative pentose phosphate pathway is required for T cell activation and antitumor immunity
Glucose is catabolized by two major metabolic pathways, glycolysis and the oxidative pentose phosphate pathway (oxPPP). The oxPPP generates nicotinamide adenine dinucleotide phosphate (NADPH) at two s...
Correction for Sachdev et al., Reversal of <i>C9orf72</i> mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision
RAD51AP1 is a versatile RAD51 modulator
RAD51AP1 is an emergent key factor in homologous recombination (HR), the major pathway for accurate repair of DNA double-strand breaks, and in alternative lengthening of telomeres (ALT). Depletion of...
Cryogenic light microscopy of vitrified samples with angstrom precision
High-resolution studies in structural biology are often limited by the challenges of crystallization and low contrast in the cellular native environment. The exquisite labeling specificity of fluoresc...
Erasable serum markers
Gene expression in the brain is typically evaluated using invasive biopsy or postmortem histology. Serum markers provide an alternative way to monitor the brain, but relatively few such markers exist....
Global stability of epidemic models with uniform susceptibility
Transmission dynamics of infectious diseases are often studied using compartmental mathematical models, which are commonly represented as systems of autonomous ordinary differential equations. A key s...
Large role of anthropogenic climate change in driving smoke concentrations across the western United States from 1992 to 2020
Wildfire activity has increased dramatically in the western United States over the last three decades, having a significant impact on air quality and human health. However, quantifying the drivers of...
Core microRNAs regulate neural crest delamination and condensation in the developing trigeminal ganglion
Cranial neural crest cells (NCCs) undergo dynamic processes during embryonic development, including delamination from the neural tube by epithelial-to-mesenchymal transition (EMT), migration to the pe...