Blood
Articles in this Issue
Real-world effectiveness of l-glutamine in Texas Medicaid patients with sickle cell disease
Abstract Introduction: Sickle cell disease (SCD) is a rare, inherited hemolytic anemia which is characterized by a range of acute and chroni...
Use of angiopoietin-2 as a biomarker in vascular anomalies beyond complex lymphatic anomalies
Abstract Introduction: The study of vascular anomalies (VA) is a rapidly evolving field with the recent discovery of som...
Peripheral blood and bone marrow immune profiles are strongly correlated in patients with plasma cell disorders
Abstract Introduction Bone marrow biopsies (BMBx) are an integral part of the diagnosis and management of plasma cell disorders (PCD) becaus...
Enhancing the sequential flamsa-treosulfan conditioning regimen with venetoclax – first results from the multicenter flamsaclax Phase I/II trial
Abstract Background: Sequential conditioning regimens are widely used to prepare patients with high-risk myeloid malignancies for allogeneic...
CDK4/6 inhibition mitigates chemotherapy-induced expansion of TP53-mutant clonal hematopoiesis
Abstract Therapy-related myeloid neoplasms (tMN) are a fatal consequence of exposure to oncologic therapy. Prior work has demonstrated that...
Phase 2 trial of zilovertamab vedotin in combination with cyclophosphamide, doxorubicin, and prednisone plus rituximab in diffuse large B-cell lymphoma: Updated analysis of waveline-007
Abstract Background: Despite progress made with combination therapies that include cyclophosphamide, doxorubicin and prednisone plus rituxim...
ASF1B promotes erythropoiesis by regulating the establishment and dynamics of H3.3 nucleosomes
Abstract ASF1B, a histone chaperon, was synergistically expressed together with the H3f3a gene encoding the histone variant H3.3 during eryt...
The role of high-dose vitamin c in management of hematological malignancies: Asystematic review and meta-analysis
Abstract Introduction: Multiple studies have demonstrated the role of Vitamin C in normal hematopoiesis; however, its...
Characterization of participants with elevated bleeding rates responding to prophylactic marstacimab treatment in the phase 3 BASIS trial
Abstract Background Marstacimab, a monoclonal antibody targeting tissue factor pathway inhibitor to reduce inhibition of the extrinsic coagu...
Direct small molecule inhibition of RAS enhances JAK2 inhibitor therapy in preclinical models of myeloproliferative neoplasms
Abstract The classical myeloproliferative neoplasms (MPNs) polycythemia vera, essential thrombocythemia, and primary myelofibrosis (MF) are...
Stability and evolution of individual-level biomarker patterns across repeated vaso-occlusive crises in sickle cell disease
Abstract Background Vaso-occlusive crises (VOCs) in sickle cell disease (SCD) are recurrent, difficult-to-predict events that significantly...
Analysis of non-driver mutation characteristics in primary myelofibrosis
Abstract Objective: This study aims to investigate the distribution characteristics, interrelationships, and impact on disease prognosis of...
Are all GELF criteria created equal? utility of individual GELF criteria as guidance for treatment initiation in patients with advanced stage FL
Abstract Background: Follicular lymphoma (FL), a largely incurable malignancy, has an indolent yet heterogenous course, with some patients (...
Early access program for danicopan (ALXN2040) as add-on treatment to eculizumab or ravulizumab in patients with paroxysmal nocturnal hemoglobinuria (PNH): Preliminary data from the Italian real-world survey.
Abstract Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematopoietic disease characterized by complement-mediated intrav...
Analysis of cKIT mutations in Acute Myeloid Leukemia and systemic mastocytosis by multiplex SuperRCA® technology
Abstract Introduction Alterations in cKIT residue D816 are the hallmark of systemic mastocytosis (SM) and are typically associated with poor...
Efficacy and safety of NTQ5082 monotherapy in complement-inhibitor-Naïve patients with paroxysmal nocturnal hemoglobinuria: A proof-of-concept, multicenter, randomized, open-label phase 2 study
Abstract Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder of hematopoietic stem cells characterized by...
Azole-adjusted venetoclax-based regimens in unfit AML patients: A real-world brazilian experience from a resource-limited setting
Abstract Background: Venetoclax-based regimens have become the standard of care for patients with newly diagnosed acute myeloid leukemia (AM...
Modeling disability reduction through low-dose prophylaxis versus on-demand therapy in hemophilia A: A meta-analysis and gbd-inspired yld framework for resource-limited settings
Abstract Low-dose prophylaxis (LDP) is increasingly adopted in low- and middle-income countries (LMICs) as a cost-feasible approach to reduc...
Targeting pathogenic alloantibody generation using a chimeric HPA-1a-containing fc fusion protein: A novel treatment for fetal and neonatal alloimmune thrombocytopenia (FNAIT)
Abstract Background: Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT) is a rare, pregnancy-associated bleeding disorder caused by mate...
Long-term follow-up of azacitidine, venetoclax, and gilteritinib in patients with newly diagnosed FLT3-mutated Acute Myeloid Leukemia
Abstract Background: Patients (pts) with FLT3-mutated acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy, especially...
Spermine alleviates EV71-induced inflammation by inhibiting GBP5 and NLRP3 activation in macrophages
Abstract Backgrounds Hand-foot-and-mouth disease (HFMD) is a common childhood infectious disease primarily caused by enteroviruses, with ent...
An investigation of somatic mutations in IDH genes in peripheral blood in the all of us research program
Abstract Background: Somatic mutations in isocitrate dehydrogenase (IDH) genes are commonly seen in acute myeloid leukemia (AML) and other m...
AI-based, secure and privacy-preserving synthetic data generation platform in transfusion-dependent β-thalassemia applied to the Webthal® dataset
Abstract Background While AI technologies for synthetic data (SD) generation are well-developed, their direct application in clinical settin...
Real-world efficacy and prognostic modeling of venetoclax-enhanced intensive chemotherapy in fit AML
Abstract Objective: This study aimed to evaluate the efficacy and safety of Venetoclax combined with intensive chemotherapy in Fit AML patie...
Early versus late onset hematologic immune-related adverse events following immune checkpoint inhibition: Temporal patterns, clinical profiles, and risk stratification in faers reports (2014–2025)
Abstract Background: Hematologic immune-related adverse events (hem-irAEs) are rare but severe complications of immune c...