Blood
Articles in this Issue
Specific targeting of HLA genes generates hypoimmunogenic hematopoietic stem cells for allogeneic transplantation
Abstract Pre-transplant human leukocyte antigen (HLA) matching between donors and recipients is essential for minimizing immunological rejec...
The association between sglt-2 inhibitor use and progression from monoclonal gammopathy of undetermined significance to multiple myeloma in US veterans
Abstract Introduction Sodium-glucose cotransporter 2 inhibitors (SGLT-2i) are antidiabetic agents with known cardio- and renoprotective effec...
Microbiome and cytokine features are associated with graft-versus-host disease incidence in allogeneic hematopoietic cell transplantation patients
Abstract Introduction The intestinal microbiota modulates the host immune-system and is particularly relevant in immune-...
Is 'severe’ imcd-IPL really severe?
Abstract Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder with heterogeneous clinical manifestations....
Targeting Epigenetic–Metabolic crosstalk in CML via butyrate-induced HDAC inhibition
Abstract Introduction Tyrosine kinase inhibitors (TKIs) have improved Chronic Myeloid Leukemia (CML) patient outcomes; however, a subset of p...
Efficacy and safety of the TEAM conditioning for autologous stem cell transplantation in lymphoma patients with high-risk of central nervous system relapse
Abstract Background: Despite advances in novel therapies, high-dose chemotherapy followed by autologous hematopoietic stem cell transplantat...
Somatic mutations in cancer-related genes in chronic myeloid leukemia patients receiving asciminib
Abstract Background: Identification of possible factors of resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML)...
Liver disease in shwachman-diamond syndrome: A report from the shwachman-diamond syndrome registry
Abstract Background: Shwachman-Diamond Syndrome (SDS) is a ribosomopathy marked by marrow failure, exocrine pancreatic dysfunction, and leuk...
Physician-reported impact of vaso-occlusive crises in people with sickle cell disease: A multinational, real-world survey
Abstract Sickle cell disease (SCD) is an inherited red blood cell disorder caused by a β-globin gene mutation producing sickle hemoglobin (H...
NSUN2/YBX1-mediated m5C modification enhances phgdh expression to drive immune evasion via PD-L1 and CCL2 axis in high-grade b-cell lymphoma
Abstract High-grade B-cell lymphoma with double-hit (HGBL-DH), distinguished by simultaneous MYC and BCL-2 rearrangements, constitutes a not...
Car-T therapies show potential benefit as second-line treatment in relapsed/refractory large B-cell lymphoma: A bayesian meta-analysis of randomized controlled trials
Abstract Introduction The advent of chimeric antigen receptor T-cell (CAR-T) therapies has transformed the management of relapsed/refractory...
Racial and ethnic disparities in u.S. chronic lymphocytic leukemia clinical trial enrollment: A participation-to-prevalence analysis
Abstract Background: Chronic lymphocytic leukemia (CLL) is the most prevalent form of adult leukemia in the United States, accounting for 20...
Preliminary safety and efficacy of myeloablative orca-q with tacrolimus or without graft-versus-host disease prophylaxis for treatment of advanced hematologic malignancies
Abstract BACKGROUND Allogeneic hematopoietic stem cell transplantation (alloHSCT) remains the only potentially curative option for several h...
Inhibition of Drp1, a mitochondrial fission GTPase disrupts mitochondrial quality control and impairs stem-like properties in Acute Myeloid Leukemia
Abstract Introduction: Mitochondrial fission is a critical aspect of mitochondrial dynamics, essential for maintaining mitochondrial functio...
Precision targeting of the malignant clone in B-cell malignancies using chimeric antigen receptor T cells against the clonotypic IGHV3-23 B cell receptor
Abstract Introduction: CD19-directed chimeric antigen receptor T-cell (CART19) immunotherapy has revolutionized the treatment of B-cell lymp...
Main biologic and clinic features at presentation and treatment results in very elderly patients (> 75 Years) with Multiple myeloma: A multicentric experience
Abstract Multiple Myeloma (MM) is often diagnosed in patients (pts) aged > 75 years. These very elderly subjects are under-represente...
Risk factors for failure to complete step-up-dosing of bispecific antibody therapy for B-cell lymphomas
Abstract Introduction: Bispecific CD20-directed/T cell-engaging antibodies (BsAbs) are FDA approved for treatment (tx) of patients (pts) wit...
From chaos to clarity? decoding the inflammatory profiles in lower-risk MDS
Abstract Introduction Immune dysregulation is increasingly recognized as both a pathogenic driver and therapeutic target in Myelodysplastic S...
Low risk for meningococcal and other encapsulated bacteria infections with systemically administered pegcetacoplan in paroxysmal nocturnal hemoglobinuria and C3 glomerulopathies
Abstract Introduction: Complement inhibitors are promising therapies for complement-mediated conditions, including paroxysmal nocturnal hemo...
Final results of a phase I/II trial of palbociclib and CPX-351 in patients with Acute Myeloid Leukemia
Abstract Introduction Cytarabine resistance limits treatment efficacy in acute myeloid leukemia (AML), due in part to the asynchronous cell c...
Development of a high-affinity antibody specific to the predominant λ light chain amyloid subtype for AL amyloidosis immunotherapy
Abstract BACKGROUND Although current quadruplet anti-plasma cell treatments effectively eliminate the production of new amyloidogenic light...
Exploring the interplay of myeloma and acute decompensated heart failure: Mortality and comorbidity insights
Abstract Background: Acute decompensated heart failure (ADHF) is a major driver of hospitalization and mortality, with outcomes potentially...
The point-of-care network with the BCMA-directed CART ARI0002h (Cesnicabtagene Autoleucel) in patients with relapsed/refractory multiple myeloma maintains efficacy and safety in real-world data
Abstract Background: ARI0002h (cesnicabtagene autoleucel) is a BCMA-CART developed at Hospital Clinic de Barcelona (HCB). Approval was grant...
TP53 mutated clonal hematopoiesis patterns over serial follow up: A single center clinic experience
Abstract Background: Clonal hematopoiesis (CH) refers to acquired myeloid neoplasm (MN)-associated mutations that are detectable in blood by...
Characterization of disease presentation and clinical outcomes of chronic myelomonocytic leukemia and myelofibrosis with monocytosis
Abstract Introduction Chronic myelomonocytic leukemia (CMML) is a hematologic malignancy defined by the presence of peripheral monocytosis a...