Blood
Articles in this Issue
Results of A phase I study of peposertib in combination with MEC in patients with relapsed or refractory Acute Myeloid Leukemia
Abstract Background: Outcomes for relapsed or refractory (R/R) acute myeloid leukemia (AML) remain poor despite advances in the treatment of...
Efficacy of pirtobrutinib monotherapy in treatment-naïve chronic lymphocytic leukemia: A Bayesian network meta-analysis of randomized controlled trials
Abstract Background BRUIN CLL-314 (NCT05254743) is a global phase 3 open-label randomized controlled trial (RCT) comparing pirtobrutinib wit...
Targeting the SDF-1/CXCR4 axis to attenuate pain in sickle cell disease: A preclinical evaluation of AMD3100 as a non-opioid therapeutic strategy
Abstract Background Sickle cell disease (SCD) is the most common monogenic disorder, affecting about 100,000 Americans a...
RBCs promote VWF tension-dependent activation and hemostatic clot formation under hemodilution: A combined in silico and ex vivo study
Abstract Introduction: Dilutional coagulopathy remains a major challenge in trauma and transfusion medicine, yet the mechanistic basis of im...
Comparative efficacy of azacitidine plus venetoclax in patients with de novo and secondary Acute Myeloid Leukemia
Abstract Background. Acute myeloid leukemia (AML) comprises a heterogeneous group of hematologic malignancies with a generally poor prognosi...
Shifting first-line paradigms: Real-world treatment outcomes and healthcare burden in non-transplant newly diagnosed multiple myeloma in France (2015-2022)
Abstract Introduction: Despite significant advancement in novel agents and combination therapies, multiple myeloma remains incurable. For pa...
Clinical characteristics, disease progression, and vascular events in essential thrombocythemia: A single-center cohort study with long-term follow-up.
Abstract Background: Essential thrombocythemia (ET) is a chronic Philadelphia chromosome negative myeloproliferative neoplasm characterized...
Quantifying the impact of vancomycin on short and long term renal function in a contemporary real-world pediatric stem cell transplant cohort
Abstract As survival rates after pediatric hematopoietic cell transplant (HCT) continue to improve, reducing toxicity and maximizing organ f...
Zamtocabtagene autoleucel, a tandem CD20-CD19 directed CAR-T cell therapy as second-line treatment for Relapsed/Refractory large B-cell lymphoma: primary analysis of the randomized, pivotal DALY 2-EU study.
Abstract Background: Zamtocabtagene autoleucel (zamto-cel) is an autologous, non-cryopreserved tandem CD20-CD19 directed CAR-T cell therapy...
Obesity is associated with poor prognosis in ph-like acute lymphoblastic leukemia
Abstract Philadelphia-like (Ph-like) B-cell Acute Lymphoblastic Leukemia (B-ALL) is a subset of high-risk (HR) ALL, constituting 5-15% of pe...
A case of acute myeloid leukemia with isocitrate dehydrogenase 1 (IDH1) mutation treated with combination therapy, ivosidenib and azacitidine
Abstract Background: Acute myeloid leukemia (AML) is the most common leukemia in adults, characterized by clonal prolife...
Utilization and tolerability of R-CHOP and R-mini–CHOP in patients with diffuse large B-cell lymphoma (DLBCL) at a community cancer center
Abstract Background: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, accounting for approximately...
Peripheral blood stem cell collection for patients with multiple myeloma undergoing autologous transplant after quadruplet induction
Abstract Background: In recent years, quadruplet induction regimens, including daratumumab, bortezomib, lenalidomide and dexamethasone (D-VR...
Biology of circulating tumor cells (CTCs) in multiple myeloma (MM): Comparative transcriptomic profiling reveals egression-associated changes related to CTC burden
Abstract Background: CTCs have emerged as a key prognostic factor in newly diagnosed (ND) MM. However, mechanisms of plasma cell (PC) egressi...
Hemoglobin uptake by liver endothelium prevents von Willebrand factor clearance in sickle cell disease
Abstract Introduction: Sickle cell disease (SCD) is an autosomal recessive genetic disorder that affects ~100,000 African Americans and over...
Dynamic changes in cytogenetic abnormalities during treatment predict long-term outcomes in multiple myeloma
Abstract Cytogenetic abnormalities detected by fluorescence in situ hybridization (FISH) at diagnosis are essential for risk stratification...
Thrombophilia testing and thrombotic risk evaluation in beta-thalassemia: A cohort analysis from a hub regional center
Abstract Background: β-thalassemia (βT) is a group of inherited hemoglobin synthesis disorders, characterized by defecti...
Trends and race-sex disparities in in-hospital mortality of chemotherapy-induced cardiomyopathy in hematologic malignancies
Abstract Background: Chemotherapy-induced cardiomyopathy (CIC) is a serious, and often irreversible complication in patients treated for hem...
Survival differences of patients with treatment-naive CLL between the chemoimmunotherapy and BTKi eras: An eric study.
Abstract Introduction: Several randomized controlled trials have demonstrated superiority of BTK inhibitors (BTKis) over chemoimmunotherapy...
Endogenous regulation of inflammatory response as a determinant of durable remission without stem cell transplant following brexucabtagene autoleucel (Brexu-cel) therapy in ALL
Abstract Introduction: Brexu-cel therapy achieved remarkable overall complete remission rates in the pivotal ZUMA-3 (NCT02614066) for adults...
ZE74-0282 is a novel JH2 domain JAK2 inhibitor with promising pre-clinical activity in JAK2 V617F mutant diseases
Abstract Background: The JAK2 V617F mutation is the most frequent recurring mutation noted in all three types of myeloproliferative disorder...
Comparative outcomes of 14,650 patients with mycosis fungoides/Sézary syndrome from academic and community cancer programs
Abstract Background: Cutaneous T-cell lymphomas are a group of lymphoproliferative disorders that are characterized by dermal infiltration b...
Real-world outcomes with CAR-T therapy in relapsed/refractory multiple myeloma and severe renal failure: A propensity matched multi-center retrospective Study using trinetx database
Abstract Introduction: Two BCMA CAR-T cell therapies ie Idecabtagene vicleucel (Ide-cel) and ciltacabtagene autoleucel (...
Serine/glycine starvation induces metabolic rewiring to uncover ATF4-driven therapeutic vulnerabilities in infant ALL
Abstract Significant progress has been made in treating childhood leukaemia's in recent decades, with a 5-year survival rate of 65%-95%. How...
Impact of fludarabine exposure on overall survival in patients receiving fludarabine/cyclophosphamide reduced intensity conditioning hematopoietic cell transplantation for hematologic malignancies
Abstract Allogeneic hematopoietic cell transplantation (alloHCT) is a potentially curative treatment for many hematologic malignancies. Redu...