Blood
Articles in this Issue
Low-dose 10-day decitabine plus venetoclax induced rapid MRD negativity and durable remission in de novo AML and high-risk MDS
Abstract Background The combination of hypomethylating agents (HMAs) and venetoclax (VEN) have emerged as a new standard of care in older or...
Venetoclax-based therapies in patients with Relapsed/Refractory T-cell prolymphocytic leukemia
Abstract Background: T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T lymphocytes with high rates of rela...
Distinct archetypes of clonal dynamics underlie response and resistance to diverse CLL therapies
Abstract Patients with chronic lymphocytic leukemia (CLL) experience variable clinical course and duration of therapeutic response. While pr...
A quality improvement project to improve the recognition and management of iron delivery in the postpartum patient
Abstract Background: Iron deficiency (ID) is highly prevalent during pregnancy and may affect up to half of pregnancies with more severe ID...
Final results from a prospective, multicenter, non-interventional study (BESREMi-PASS) on the safety of ropeginterferon alfa-2b in 229 patients with polycythemia vera
Abstract Introduction Ropeginterferon alfa-2b (ropeg), a next-generation mono-pegylated interferon (IFN) demonstrated a favorable safety and...
Evaluation for non-accidental trauma (NAT) and bleeding disorders in infants referred to pediatric hematology
Abstract Introduction: The most common presentation for both pediatric non-accidental trauma (NAT) and bleeding disorders is bruising. In no...
Self-reported geriatric impairments and treatment toxicity in older patients with multiple myeloma - a single center prospective study
Abstract Introduction: Multiple myeloma (MM) predominantly affects older adults who vary widely in physiological status and treatment outcom...
What is the optimal threshold for aberrant lymphoblasts at diagnosis to predict lymphoid transformation in chronic myeloid leukemia?
Abstract Abstract Aim: To explore the prognostic proportion of bone marrow aberrant lymphoblasts (ALB) detected by flow cytometry (FCM) for...
CD7-targeted universal CAR T-cell therapy in relapsed or refractory (R/R) acute myeloid leukemia (AML): Clinical results from CTD401/402 studies
Abstract Introduction: CAR-T cell therapy has transformed lymphoid malignancy treatment but remains challenging in AML due to lack of safe t...
Unsupervised clustering of DDX41 mutants informs on the somatic landscape of single germline hits
Abstract Germline DDX41 mutations can occur in monoallelic form or in the context of somatic hits, predominantly R525H. While germline DDX41...
A phase 2 study with tafasitamab and zanubrutinib in newly diagnosed chronic lymphocytic leukemia/small lymphocytic lymphoma – taza CLL
Abstract Background: Frontline therapy of chronic lymphocytic leukemia (CLL) typically consists of a Bruton tyrosine kinase inhibitor (BTKi)...
Basal and stimulated intra-RBC and exported ATP and RBC adhesivity ex vivo in children with sickle cell disease
Abstract INTRODUCTION Sickle cell disease (SCD) represents a significant global health burden, and is characterized by hemolytic anemia, vaso...
Myeloid malignancies molecular analysis for therapy choice (myeloMATCH): Rapid availability of clinical, pathologic and molecular features for treatment assignment in the first 550 patients.
Abstract Background: MyeloMATCH is an NCI-sponsored initiative for acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) employing...
Orelabrutinib for elderly patients with stage IV marginal zone lymphoma involving the central nervous system: A case report and clinical implications
Abstract Background: Marginal zone lymphoma (MZL) is a heterogeneous disease accounting for 7% of non-Hodgkin lymphomas. The lack of a stand...
Babesiosis masquerading as ITP in a patient with CLL
Abstract Introduction: We report a case of severe thrombocytopenia, which was initially thought to be a consequence of I...
Pre-transplant physical function and sarcopenia assessment in allogeneic stem cell transplant recipients: A cross-sectional analysis from a multidisciplinary program
Abstract Introduction Advances in allogeneic stem cell transplantation (alloSCT) have improved survival, yet long-term c...
Preliminary anti-leukemia activity from A phase 1 study of cln-049, a novel anti-FLT3 x anti-CD3 bispecific T-cell engager, in Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) and myelodysplastic syndrome (MDS)
Abstract Background Common targets for T-cell–redirecting immunotherapies in AML and MDS have previously presented challenges. CLN-049 is a...
Use of simulation-based education to mitigate race- and disease-based discrimination in sickle cell disease care
Abstract Introduction Patients living with sickle cell disease (SCD) have a life-threatening disease causing a decreased...
BCMA+ extracellular vesicles predict response and toxicity in patients with multiple myeloma treated with anti-BCMA bispecific antibodies
Abstract Anti-BCMA bispecific antibodies (BiAbs) improved outcomes of patients (pts) with relapsed/refractory multiple myeloma (RRMM). In th...
Evaluation of PET/CT during upfront therapy as a prognosticator in follicular lymphoma patients at the University of Debrecen
Abstract Introduction: Traditional prognostic indices, while widely used, exhibit limitations in comprehensively delineating the clinical he...
Integrated modeling analyses for belantamab mafodotin in combination with standard of care in patients with Relapsed/Refractory multiple myeloma (RRMM) from dreamm-6, dreamm-7, and dreamm-8
Abstract Introduction: Belantamab mafodotin was investigated for RRMM in combination with lenalidomide + dexamethasone in Arm A of the phase...
MDS without clonal marker: When depth outperforms breadth
Abstract Background: Myelodysplastic neoplasms (MDS) are a heterogeneous group of clonal myeloid neoplasms. The interpla...
Mortality trends of chronic lymphocytic leukemia and pneumonia in the United States (1999–2023): A CDC-wonder analysis
Abstract INTRODUCTION: Chronic lymphocytic leukemia (CLL) is the most prevalent white blood cell malignancy in the United States and account...
Prevalence, incidence, and outcomes of multiple myeloma patients using electronic health records and natural language processing
Abstract Background: A comprehensive understanding of multiple myeloma (MM) in real-world settings is essential to improve patient care and...
Discovery of first-in-class calr-targeted precision ADCs delivering a CDK9degrader payload for the treatment of calr-mutated MPNs
Abstract Myeloproliferative neoplasms (MPNs) are driven by clonal hematopoietic stem cells (HSCs), yet current therapies primarily address s...