Blood
Articles in this Issue
Efficacy and safety of HSK39297 monotherapy in patients with paroxysmal nocturnal hemoglobinuria (PNH)
Abstract Introduction Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder characterized by complement-mediated hemolysi...
Therapeutic plasma exchange and intravenous immunoglobulin facilitate safe heparin re-exposure in acute heparin-induced thrombocytopenia: A five-patient case series
Abstract Background: Urgent cardiopulmonary bypass (CPB) in acute heparin-induced thrombocytopenia (HIT) presents a clinical challenge. Dire...
Mini-ATG/TBI conditioning regimen facilitates cure of acquired aplastic anemia in children via unrelated umbilical cord blood transplantation
Abstract Introduction: Umbilical cord blood transplantation (UCBT) represents a alternative therapeutic option for patients with acquired ap...
RAS mutations are frequent in extramedullary AML and drive the tissue infiltration of leukemic cells via the induction of jaml
Abstract Extramedullary acute myeloid leukemia (EML) is a rare manifestation of acute myeloid leukemia (AML), where myeloid blasts invade ex...
CpG-level DNA methylation analysis identifies molecular events that are definitive of progressive lineage commitment in hematopoiesis
Abstract Epigenetic mechanisms such as DNA methylation play critical roles in orchestrating hematopoietic differentiation, yet the fine-scal...
Comprehensive and rapid detection of genomic alterations in pediatric leukemias using whole-genome sequencing with adaptive sampling
Abstract Molecular and cytogenetic classification is essential for risk stratification and therapeutic decisions in pediatric leukemias. Con...
Mediastinal myeloid sarcoma
Abstract Myeloid Sarcoma is a rare tumor mass composed of immature myeloid cells that can affect any anatomical structure and is often misdi...
Social vulnerability and mortality trends in Acute Myeloid Leukemia in the United States adults (2010 to 2020): The paradoxical role of minority-language communities
Abstract Background: Prior work has indicated racial, ethnic and geographic disparities in treatment access and outcomes for acute myeloid l...
Performance of radiomics features in patients with peripheral T-cell lymphoma: Data from international prospective T-cell project 2.0
Abstract Introduction: Peripheral T-cell lymphomas (PTCLs) are a rare, heterogeneous group of hematological malignancies with extremely poor...
The burdens associated with receiving CAR T-cell therapy: A qualitative study of CAR T patients and caregivers
Abstract Background: Chimeric antigen receptor T-cell therapy (CAR T) offers potential progression-free survival among patients with hematol...
Patterns of antiphospholipid antibody positivity in a real-world laboratory over two decades
Abstract Background Antiphospholipid syndrome (APS) is diagnosed when vascular thrombosis or pregnancy morbidity occurs in the presence of p...
Not all that glitters is gold: A simple clinical score to unmask adverse SF3B1WT MDS-RS with low blast count
Abstract INTRODUCTION Myelodysplastic syndromes with ring sideroblasts (MDS-RS) are typically associated with SF3B1 mutations (SF3B1MUT) and...
Household material hardship as a barrier to accessing sickle cell disease curative therapy
Abstract Introduction: Sickle cell disease (SCD) is a highly morbid and life-threatening condition that affects 100,000 Americans, resulting...
Using a magnetic column separator to determine the magnetophoretic behavior and adhesion characteristics of oxygenated sickle and healthy red blood cells
Abstract Introduction:Sickle cell disease (SCD) patients experiencing severe crises often require red blood cell (RBC) exchange transfusions...
Delta oscillation enhancement and alpha oscillation attenuation as electroencephalogram biomarkers of CNS demyelination in patients with hematologic malignancies
Abstract Background: Central nervous system demyelinating disease (CNSD) is a frequent and diagnostically challenging neurological complicat...
Mutated and enucleated TIM3 regulates function of Acute Myeloid Leukemia stem cells through c-MYB
Abstract Drug resistance and recurrence are important causes of poor prognosis in acute myeloid leukemia (AML), and leukemia stem cells (LSC...
Dysregulated lung microbiota impaired hematopoietic stem cell function in mice with pulmonary diseases.
Abstract Hematopoietic stem cells (HSCs), characterized by long-term self-renewal ability and multilineage differentiation potential, are a...
Next-generation tumor-specific anti-CD30 ADC as a new therapy in hemato-oncology
Abstract Context. CD30 is a type I transmembrane protein widely expressed in various lymphomas, such as B-cell Hodgkin lymphoma. Its recepto...
The impact of HLA loss of heterozygosity on outcome after haploidentical hematopoietic stem cell transplantation in hematological malignancies
Abstract Background: Genomic loss of the mismatched HLA haplotype (HLA-Loss) is a frequent mechanism of immune evasion and relapse following...
Pharmacometric analyses supporting apixaban doses in neonates with venous thromboembolism
Abstract Introduction Apixaban is an oral, direct, selective factor Xa (FXa) inhibitor approved in the US (ELIQUIS® [apixaban]. US Prescribi...
SF3B1 mutations K700E, K666N, and R625H: Gene expression and aberrant splicing consequences
Abstract Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis...
The disguise of dyscrasia: Hereditary von Willebrand disease unmasked by MGUS-associated acquired VWD
Abstract Introduction: A 70-year-old male initially underwent evaluation for suspected multiple myeloma and was found to have IgG monoclonal...
Zanubrutinib + venetoclax for treatment-naive chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), including patients with del(17p) and/or TP53 mutation and unmutated immunoglobulin heavy-chain variable status: 3-year results from SEQUOIA arm D
Abstract Introduction Fixed-duration treatment (tx) is emerging as a key therapeutic strategy for tx-naive (TN) CLL. However, high risk pati...
Sustained remission following limited duration of bispecific antibody therapy in patients with relapsed/refractory multiple myeloma
Abstract Introduction: While bispecific/multispecific antibodies (bsAb) have revolutionized the treatment of relapsed/refractory multiple my...
Leveraging real-world workshop insights for improving education design: Patient-centered care of myelofibrosis with JAK inhibitors
Abstract Background: The treatment landscape for myelofibrosis (MF) has evolved significantly, with an increasing number of JAK inhibitors (...