Blood
Articles in this Issue
Blinatumomab consolidation in high-risk Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia in adults: Final report of the graall-2014/b-QUEST study.
Abstract Rationale. Young adults with Philadelphia chromosome–negative (Ph-negative) B-cell acute lymphoblastic leukemia (B-ALL) have benefi...
Bi-allelic germline SH2B3 loss in pediatric B-ALL with cirrhosis and autoimmunity
Abstract SH2B3 encodes LNK protein, a negative regulator of JAK-STAT and RTK signaling. Pathogenic loss-of-function bi-allelic germline vari...
Enhanced engraftment and immune recovery in thalassemia via optimized conditioning for TCRαβ⁺-depleted haploidentical transplants
Abstract Background TCRαβ⁺/CD19⁺-depleted haplo-HSCT (TDH) reduces the risk of graft-versus-host disease (GVHD) in thalassemia major (TM) pa...
A retrospective study on orelabrutinib combined with anti-CD20 monoclonal antibody regimen in treating mucosa-associated lymphoid tissue lymphoma.
Abstract Objective: Mucosa-associated lymphoid tissue (MALT) lymphoma represents a distinct subtype among marginal zone lymphomas (MZL). The...
The efficacy and safety of luspatercept in patients with low-blasts myelodysplastic neoplasms in real world
Abstract Backgroud: Myelodysplastic neoplasms (MDS) are characterized by myelodysplasia and ineffective hematopoiesis leading to refractory...
Caramel: Dual-targeting (CD123/CD33) CAR-T cell as a bridge to allogeneic transplantation for Relapsed/Refractory Acute Myeloid Leukemia. preclinical Results.
Abstract Introduction Relapsed or refractory acute myeloid leukemia (R/R AML) remains a major therapeutic challenge. The application of chim...
Targeted liver assessment and the role of biopsy prior to gene therapy and HSCT in transfusion-dependent β-thalassemia: Addressing an unmet need in the absence of standardized protocols
Abstract Introduction Liver assessment plays a pivotal role in pre-transplant work up in gene therapy and Hematopoietic Stem Cell Transplant...
Research on co-mutated genes in FLT3-ITD-positive acute myeloid leukemia
Abstract Background: The FLT3-ITD (FMS-like tyrosine kinase 3 internal tandem duplication) mutation is prevalent in 20%–30% of acute myeloid...
CD19-directed CAR T-cell therapy for B-cell lymphoid malignancies is safe and effective in people living with HIV (PWH) – a matched cohort analysis by the center for international blood and marrow transplant research (CIBMTR) and the AIDS malignancy consortium (AMC)
Abstract Background: Despite a decreasing incidence, NHL remains the leading cause of cancer-attributable deaths in PWH (Horner MJ, et al. C...
GVHD-free/relapse-free survival in severe aplastic anemia: Outcomes following allogeneic hematopoietic cell transplantation: King hussein cancer center experience
Abstract Introduction: Severe Aplastic Anemia (SAA) is a life-threatening hematopoietic stem cell disorder; Allogeneic hematopoietic stem ce...
Retrospective analysis of 30mg/kg ATLG in preventing GVHD after haploidentical hematopoietic stem cell transplantation
Abstract Background: Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) has emerged as a critical treatment option for pati...
Complement-induced procoagulant platelets in patients with antiphospholipid antibodies
Abstract Introduction Antiphospholipid syndrome (APS), an autoimmune disease characterized by persistent circulating antiphospholipid antibo...
Outcomes of bispecific T-cell engagers in MM patients with central nervous system (CNS) involvement
Abstract Background Patients (pts) with multiple myeloma and CNS involvement (CNS MM) have poor outcomes, and we recently showed that CAR-T...
Impact of prolonged hospitalization on outcomes in acute leukemia: A national inpatient sample analysis
Abstract Background: Acute leukemia (AL), which includes both acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), often req...
Pre-treatment immune profiling by flow cytometry and single-cell transcriptomics identifies distinct features in B and T cells in rituximab responders and non-responders
Abstract Introduction Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disorder defined by low platelet counts (<100×10⁹/L...
Use of emicizumab in patients with acquired hemophilia A: An interim safety analysis of a large-scale post‑marketing surveillance study
Abstract Background: Acquired hemophilia A (AHA) is a rare autoimmune disorder in which autoantibodies neutralize coagulation factor VIII (F...
Sight: Sickle cell identification from general hematological testing, a machine learning approach for rapid screening in emergency medicine
Abstract Background: Rapid and accurate identification of sickle cell disease (SCD) is crucial in emergency medicine, with the chronic compl...
Efficacy of tocilizumab prophylaxis in preventing cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome: A systematic review and meta-analysis
Abstract Introduction: Chimeric antigen receptor T cell therapy (CAR-T) and bispecific antibodies have revolutionized th...
Updated efficacy and safety results of the Bruton tyrosine kinase degrader BGB-16673 in patients with relapsed/refractory indolent non-Hodgkin lymphoma from the ongoing phase 1 CaDAnCe-101 study
Abstract Introduction: BGB-16673 is an orally available protein degrader that blocks BTK signaling by tagging BTK for degradation through the...
Characterization of the human erythromyeloblastic islands (EMBIs)
Abstract The erythroblastic island (EBI) was first described in 1958, by Marcel Bessis, as a niche composed of a central macrophage (Μφ) sur...
Utility of diagnostic bone marrow examinations for cytopenias and impact on clinical management: A practice audit
Abstract Background: Bone marrow examination (BME) is frequently performed for unexplained cytopenias, with wide variations in clinical thre...
Title: Role of primary VTE prophylaxis in pediatric leukemia, lymphoma, and solid tumors: A systematic review and meta-analysis.
Abstract Background/ introduction: Venous thromboembolism (VTE) is an increasingly recognized cause of morbidity in children, particularly am...
Safety and efficacy of implanted port use for CAR T-cells infusion in large B-cell lymphoma
Abstract Background: Peripherally inserted central catheter (PICC) is the most commonly utilized central venous access for chimeric antigen...
Transcriptome sequencing of Hodgkin lymphoma Hodgkin and reed-stenberg cells reveals escape from NK cell recognition and an unfolded protein response
Abstract Classic Hodgkin lymphoma (cHL) is a B cell malignancy characterized by rare malignant Hodgkin and Reed-Sternberg (HRS) cells within...
Consolidation with loncastuximab tesirine for large B-cell lymphoma patients in partial response after CART: Planned interim futility analysis of a phase II trial
Abstract Introduction. Approximately 30% of patients with large B-cell lymphoma (LBCL) achieve a partial response (PR) after CAR T-cell ther...