Blood
Articles in this Issue
CXXC1 is required for IRF4 chromatin binding and expression and regulates cellular fitness in lenalidomide-sensitive and -resistant myeloma cells
Abstract IRF4 is a plasma cell lineage-defining transcription factor that orchestrates important aspects of the oncogenic transcriptome in m...
NF-κB is a potential therapeutic target for histone deacetylase inhibitor-resistant cutaneous T-cell lymphoma
Abstract Background: Cutaneous T-cell lymphoma (CTCL) is a malignant T-cell lymphoma that proliferates and progresses in the skin. Advanced-...
Trial in progress: A phase 3, multi-regional, open-label, randomized study of tirabrutinib vs rituximab and temozolomide in participants with Relapsed/Refractory primary central nervous system lymphoma
Abstract Background and Significance Primary central nervous system lymphoma (PCNSL) is a rare, highly aggressive form of non-Hodgkin lymphom...
Time-dependent long short-term memory neural cox regression in 2,690 patients with myeloid neoplasias treated with diverse therapies identifies bone marrow related information to be less important than expected in the context of other available clinical parameters: Insights from the AML-001 trial (NCT01074047) and the austrian myeloid registry (NCT04438889) of the AGMT study group
Abstract Introduction Morphologic complete remission (CR) or composite CR (cCR), requiring bone marrow evaluations (BMEs), remains the stand...
Evaluating ribosomal readthrough as a precision medicine strategy for restoring factor VIII expression in hemophilia a
Abstract Current prophylactic treatments for hemophilia A (HA) primarily rely on factor replacement therapies, which consist of intravenous...
CD3⁺cell dose is an independent risk factor for grade II–IV aGVHD following cord blood transplantation in children with aplastic anemia
Abstract Introduction Cord blood transplantation (CBT) has been widely used in hematologic malignancies with favorable outcomes. The use of...
Preliminary safety and efficacy of anti-CD19/CD20 bispecific CAR-T cell therapy (JWCAR201) in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: Results from an ongoing phase I study
Abstract Background Relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) represents a significant therapeutic challenge, with...
A blood-based protein signature adds to genomic prognostication of survival in TP53-mutated Acute Myeloid Leukemia
Abstract Background Outcomes for patients (pts) with newly diagnosed acute myeloid leukemia (AML) have improved significantly with the advent...
Decoding multi-compartmental immune pathways in antibody-mediated and dose-stratified murine TRALI via high-dimensional cytometry and targeted proteomics
Abstract Transfusion-related acute lung injury (TRALI) remains one of the most severe and under-treated complications of blood transfusion....
Clinical significance of blood EBV-DNA in peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) and EBV-positive nodal T-cell lymphoma
Abstract Background: Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), is a predominantly nodal, diagnosis-of-exclusion entity...
Outcomes and prognostic factors in patients with follicular lymphoma treated with front-line bendamustine and rituximab
Abstract Background Combination therapy with bendamustine and rituximab (BR) is a safe and effective front-line regimen in patients with fol...
The CDK7 inhibitor THZ1 overcomes venetoclax resistance in acute myeloid leukemia through dual regulation of p53 signaling and transcriptional networks
Abstract Background: Venetoclax (Ven), a selective BCL-2 inhibitor, has shown clinical efficacy in AML, but the mechanisms underlying resist...
The influence of racial, socioeconomic, and geographic disparities in the survival of patients with plasmablastic lymphoma: A population-based analysis from the surveillance, epidemiology, and end Results (SEER) database (2000–2022).
Abstract Background: Plasmablastic lymphoma (PBL) is a rare, aggressive subtype of large B-cell lymphoma with poor outcomes and limited popu...
Immune deconvolution from whole transcriptomic data suggests expansion of exhausted T-cells and natural killer cells following tyrosine kinase inhibitor therapy in chronic myeloid leukemia patients
Abstract Introduction Tyrosine kinase inhibitor (TKI) therapy, while targeting leukemic cells, also alters the immune landscape in chronic m...
Granulocyte maturation and splicing defects in DDX41-mutated leukemia
Abstract Deleterious germ line DEAD-box helicase 41 (DDX41) variants cause an inherited predisposition to adult-onset acute myeloid leukemia...
Preliminary safety and efficacy of the frida study: Iadademstat and gilteritinib in FLT3-mutated relapsed/refractory acute myeloid leukemia
Abstract Background: Fms-related tyrosine kinase 3 (FLT3) mutations occur in 30-40% of patients (pts) with AML (frontline and relapsed/refra...
CRLF2-rearrangement and extramedullary disease in B-cell acute lymphoblastic leukemia: A possible link?
Abstract Introduction: Cytokine receptor-like factor 2 rearrangement (CRFL2r), a Philadelphia chromosome-like (Ph-like) aberration, is a poo...
More than IL-2: Optimizing feeder-free NK cell function through cytokine synergy
Abstract Introduction Natural killer (NK) cells represent a promising therapeutic immune cell sources for the treatment...
Transitioning from FISH to NGS for immunoglobulin translocation detection in multiple myeloma
Abstract The International Myeloma Society and International Myeloma Working Group recently updated the definition of high-risk multiple mye...
Real-world comparative bleeding outcomes of direct oral anticoagulants versus warfarin in adults: Insights from observational evidence
Abstract Background: Direct oral anticoagulants (DOACs) – apixaban, rivaroxaban, dabigatran, and edoxaban– are increasingly preferred over w...
Real-time interleukin-6 (IL-6) kinetics predict cytokine release syndrome (CRS) in patients receiving chimeric antigen receptor (CAR) T-cell therapy for Relapsed/Refractory B-cell malignancies
Abstract Background Cytokine release syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS) are common, potential...
Mismatched unrelated and haploidentical transplant with post-transplant cyclophosphamide-based graft versus host disease prophylaxis are effective for myelofibrosis
Abstract Background Allogeneic hematopoietic cell transplant (HCT) remains the only curative option for myelofibrosis (M...
Do chip mutations predict frailty and toxicity in transplant-eligible patients with multiple myeloma?
Abstract Background We have previously reported that current frailty tools have limited ability to predict treatment-related toxicity in tra...
Treatment patterns and outcomes for large B-cell lymphoma patients with central nervous system relapse: A multicenter retrospective study (CoNSensus Study)
Abstract Background: Secondary central nervous system lymphoma (SCNSL) occurs in patients (pts) with large B-cell lymphoma (LBCL) and is ass...
Total body irradiation and cigarette smoking interact to increase the risk of lung cancer in blood or marrow transplant (BMT) survivors – a BMTSS report
Abstract Introduction: Chest radiation-related lung cancer has been previously reported in cancer survivors (Lorigan et al, Lancet Oncology,...