Blood
Articles in this Issue
MiR-146b restoration in T-large granular lymphocyte leukemia: Molecular insights for a new therapeutic strategy
Abstract INTRODUCTION T-Large Granular Lymphocyte Leukemia (T-LGLL) is a rare lymphoproliferative disorder characterized by the clonal expan...
Unexplained thrombosis and profound monocytopenia in an adolescent: Delayed diagnosis of GATA2 haploinsufficiency
Abstract Introduction: GATA2 haploinsufficiency, or MonoMAC syndrome, is an autosomal dominant disorder characterized by monocytopenia and m...
Diagnostic accuracy and challenges of AI/ML models for sickle cell disease detection in blood smears: A meta-analysis and systematic review
Abstract Introduction: Sickle cell disease (SCD) is a genetic blood disorder affecting millions worldwide, requiring early and accurate diag...
High remission rates with FLAG-ida-venetoclax in acute myeloid leukemia: “Less is More” on days of venetoclax in the intensive regimen
Abstract Background: Despite significant advances in treatment of AML over the past decade, long-term survival remains poor. The addition of...
Examining folate and B12 deficiency in patients following allogeneic transplant
Abstract Background: Patients (pts) undergoing allogeneic hemopoietic stem cell transplant (alloHSCT) often have poor oral intake, which may...
Efficacy and safety of mini-CVD combined with venetoclax and azacitidine in acute leukemia of ambiguous lineage: A single-center retrospective study
Abstract Background:Acute leukemias of ambiguous lineage (ALAL) is a rare type of hematologic malignancies with poor outcomes. Currently, th...
Utilization patterns of venetoclax-based regimens for AML in a community based setting & representative populational analyses
Abstract Introduction: Azacitidine and Venetoclax was approved for older patients in 2020 ineligible for intensive chemotherapy, and it has...
Dietary serine restriction increases venetoclax efficacy in Acute Myeloid Leukemia
Abstract Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy with relapse rates exceeding 50% and long-term survival...
Patient characteristics, treatment patterns, and outcomes in primary CNS lymphoma of T-cell origin: A multi-institution retrospective analysis
Abstract Introduction: Primary central nervous system T-cell lymphoma (PCNSTL) is a rare form of PCNSL, comprising 2–8% of cases. Prognostic...
Absence of circulating tumor cells (CTCs) defines a subtype of multiple myeloma (MM) patients (Pts) with unique clinical and biological features
Abstract Background: Evidence suggests that CTCs are responsible for MM spreading and therefore prognostic. However, some pts unexpectedly h...
SF3B1 mutations are associated with shorter time to first treatment in chronic lymphocytic leukemia
Abstract Background: Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous hematologic malignancy. The identification of risk fact...
Reprogrammed regulatory T cells as cytotoxic effectors drive anti-tumor immunity under bispecific T cell engager therapy
Abstract Background: Bispecific T cell engagers (BTCEs) have transformed the treatment of multiple myeloma (MM) and B cell malignancies by re...
Characteristics of immune genes rearrangements in Chinese multiple myeloma patients
Abstract Introduction:For improving outcomes of patients in early treatment, diverse detections were developed for prognosis prediction. Mul...
Pharmacological targeting of CTPS1 elicits macrophage-mediated anti-leukemia immunity
Abstract Immunotherapy, including immune checkpoint inhibitors, antagonizes many hematologic malignancies, but has transient effects on acut...
Delays in hydroxyurea initiation for patients with sickle cell disease in British Columbia
Abstract Introduction: Sickle cell disease (SCD) is a hereditary hemoglobinopathy characterized by abnormal hemoglobin S that polymerizes to...
Association of platelet count and mean platelet volume with clinical outcomes in pulmonary embolism: A retrospective cohort study
Abstract Introduction Mean platelet volume (MPV) and platelet count have been proposed as prognostic markers in thrombotic and bleeding diso...
Computational dissection of immune reconstitution across diverse conditioning regimens in adults with sickle cell disease undergoing allogeneic stem cell transplantation
Abstract Background: Allogeneic hematopoietic stem-cell transplantation (HSCT) is curative for adult sickle-cell disease (SCD). Yet donor so...
Transition to ixazomib-based maintenance following daratumumab-based induction for continuous therapy in newly diagnosed multiple myeloma
Abstract Background:Continuous treatment is essential for achieving sustained disease control in multiple myeloma (MM). Daratumumab(Dara)-ba...
Overall survival (OS) in patients with metastatic colorectal cancer (mCRC) following persistent chemotherapy-induced thrombocytopenia (pCIT)
Abstract Introduction: Literature suggests an increased risk of mortality in patients with solid tumors and thrombocytopenia, but data on OS...
Single-cell metabolic profiling of T cells identifies a fitness signature associated with early CAR T failure in large B cell lymphoma
Abstract Introduction Chimeric antigen receptor T cell (CAR T) therapy for relapsed/refractory large B-cell lymphoma (LBCL) achieves long-ter...
Clinical significance of apoe genotypes in older adults with Acute Myeloid Leukemia: Insights from a consecutively treated cohort
Abstract Background: Apolipoprotein E (APOE) exists in three major isoforms—ε2, ε3, and ε4—which differentially influence tumor immunity by...
CⅡTA-mediated up-regulation of MHC reverses immune evasion of leukemia stem cells in refractory/relapsed AML
Abstract Background Leukemia stem cells (LSCs) are recognized as the principal reservoir driving chemoresistance and relapse in acute myeloi...
Optimizing board exam outcomes: A structured exam preparation curriculum for hematology/oncology fellows
Abstract Background Achieving board certification is a critical marker of baseline clinical competence in early career h...
Acalabrutinib vs zanubrutinib as first-line therapy in CLL: A propensity score–matched study
Abstract INTRODUCTION: Covalent Bruton tyrosine kinase inhibitors (cBTKis) have transformed the treatment paradigm of chronic lymphocytic le...
Parental perspectives on financial distress during treatment for childhood acute lymphoblastic leukemia: A qualitative report from Children's oncology group (COG) study ACCL20N1CD
Abstract Introduction: Cancer-related financial hardship among families of children with cancer contributes to poor qual...