Blood
Articles in this Issue
Celmods potently inhibit m-MDSC induction by targeting IL-10 and MIF in multiple myeloma
Abstract Background Myeloid-derived suppressor cells (MDSCs), which include polymorphonuclear-MDSCs and monocytic MDSCs (M-MDSCs), play key...
Impact of thrombocytopenia on hemorrhage and recurrent thrombosis in patients with cancer associated thrombosis, a time varying analysis
Abstract IntroductionBoth venous thromboembolism (VTE) and thrombocytopenia are frequent complications in patients with cancer. Managing can...
MBS314, a GPRC5DxBCMAxCD3 trispecific antibody, in relapsed/refractory multiple myeloma (RRMM): Updated results from a Phase 1 dose escalation study
Abstract Background: Multiple myeloma (MM) is a highly heterogeneous, incurable hematologic malignancy. BCMA and GPRC5D are highly expressed...
Rising mortality from coexisting hypertension and aplastic anemia in the United States, 1999–2023: A 25-year analysis of national disparities and public health gaps
Abstract Background Hypertension is one of the most prevalent chronic conditions in the United States and a leading cont...
Functional analysis of STAT3 activating mutations in LGL leukemia reveals epigenetic reprograming and therapeutic vulnerabilities.
Abstract STAT3 activating mutations, present in 40-70% of large granular lymphocytic leukemia (LGLL) patients, are associated with worse pro...
CXCL9 is a predictive biomarker of survival with IFNγ-targeted therapy in adult HLH patients
Abstract INTRODUCTION Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory state triggered by diverse conditions...
Automatic identification of blast leukemic cells types using deep learning with vision transformers.
Abstract Background: Acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)are heterogeneous hematopoietic neoplasms with poor...
Establishing the impact of effective donor-specific antibody (DSA) desensitisation in haploidentical and mismatched donor haematopoietic stem cell transplants: An Australian experience
Abstract Background: The presence of donor-specific antibodies (DSA) in recipients undergoing allogeneic hematopoietic stem cell transplant...
Chest imaging prior to allogeneic bone marrow transplant: A retrospective study of pre-transplant workup outcomes
Abstract Introduction: Allogeneic bone marrow transplant (BMT) patients are prone to pulmonary infections and neutropenic fever due to their...
Changes in real-world treatment patterns over time by patient characteristics and time burden of treatment in CLL/SLL
Abstract Background The chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) treatment (tx) landscape has changed recently. The...
Caplacizumab for pediatric immune thrombotic thrombocytopenic purpura: A scoping review of current evidence
Abstract Introduction: Immune thrombotic thrombocytopenic purpura (iTTP) in children is a rare form of thrombotic microangiopathy characteri...
Updated results of A phase II study of blinatumomab in adults with measurable residual disease of 10-4 or higher
Abstract Background: Measurable residual disease (MRD) is the strongest predictor for relapse and survival in patients (pts) with B-cell acu...
Improving bone marrow biopsy core length and aspirate adequacy through implementation of a powered device: A single-institution quality improvement initiative
Abstract Background: Adequate bone marrow (BM) examination is essential for diagnosing, staging, and monitoring hematologic disorders. Subop...
Transitioning patients from warfarin to direct oral anticoagulants: A dual-benefit quality improvement initiative
Abstract Background: Anticoagulation is commonly used to prevent and treat thromboembolic events. Warfarin is a cost-effective anticoagulant...
Cutaneous diffuse large B-cell lymphoma induce a macrophage immunosuppressive phenotype through IL-10 secretion
Abstract Background : Tumor associated macrophages (TAM) may endorse a large range of phenotype and functions owing to their plasticity and...
Ending the undetermined significance of monoclonal gammopathies (MGUS): First results of the nomoremgus study
Abstract Background: MGUS is considered a benign condition despite being associated with shorter survival when compared to matched control p...
Replacing FISH with a comprehensive integrated approach for tumor genotyping and immune monitoring in multiple myeloma: The flagship study
Abstract Background: Several genomic research efforts in multiple myeloma (MM) have revealed clinically relevant molecular subgroups beyond...
Safety and preliminary efficacy of a novel loop-optimized, BCMA/CD19 bispecific CAR-T therapy for refractory or relapsed autoimmune diseases patients
Abstract Background:Anti-CD19 CAR-T cell therapy has achieved breakthrough efficacy in B cell-driven autoimmune diseases such as systemic lu...
DDX3X facilitates adaption to proteotoxic stress by regulating the translation of MAPKAPK2 and the stability of TMCO1 via stress granules in multiple myeloma
Abstract INTRODUCTION Endoplasmic reticulum stress (ERS) / unfolded protein response (UPR) is essential for multiple myeloma (MM) cell surviv...
Phase II investigator-initiated trial of epcoritamab-lenalidomide in treatment naïve follicular lymphoma
Abstract Background Bispecific antibodies offer chemotherapy-free, time-limited options with reduced toxicity and durable responses for fron...
The chromatin remodeling protein ARID1A is required for MLL-AF9 leukemogenesis
Abstract The SWI/SNF chromatin remodeling complexes regulate gene transcription by modulating chromatin accessibility. Three SWI/SNF subcomp...
A Canadian national needs assessment for an immunology curriculum for hematology residents
Abstract Background: Hematology training in Canada is competency-based and consists of two years of integrated clinical and laboratory train...
Genetics of lymphomas in Ecuador
Abstract Lymphomas arise in any body region containing lymphatic tissue and are mainly classified into Hodgkin lymphoma (HL) and non-Hodgkin...
Hi-c FFPE sequencing analysis is highly concordant with FISH and detects additional variants informing diagnosis and treatment in diffuse large B-cell lymphoma
Abstract Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL), accounting for approximatel...
Associations between chronic kidney disease, proteinuria, and thrombotic risk in SCD
Abstract Background: Sickle cell disease (SCD) is characterized by early onset of frailty and age-related complications, including heart dis...