Blood
Articles in this Issue
A lean thinking approach to improve efficiency in providing immune-chemotherapy injection in out-patient service: A pivotal study
Abstract Background The administration of chemotherapy in a hospital setting is intrinsically complex, involving a highly regulated chain of...
IDH2 mutant hematopoietic stem and progenitor cells promote endothelial niche remodeling
Abstract Myelodysplastic syndromes (MDS) are a group of hematologic disorders, characterized by a block in differentiation of myeloid-lineag...
A comparative analysis of epigenetic age acceleration across distinct hematopoietic clones in hematologic diseases
Abstract Studiesbased on the Horvath methylation clock have demonstrated that biological age, estimated based on methylation levels at speci...
Patient perspectives on the burden of hypereosinophilic syndrome: Results from the Phase 3 natron interview sub-study
Abstract Background Hypereosinophilic syndrome (HES) encompasses a group of rare disorders characterized by persistently high levels of eosi...
Molecular characterization of patients (pts) with myeloproliferative neoplasms treated with INCA033989 demonstrates selective targeting of CALR mutant hematopoietic cells
Abstract Background: Essential thrombocythemia (ET) and myelofibrosis (MF) are driven by mutations in calreticulin (mutCALR) in ~30% of pati...
QTc prolongation in allogeneic bone marrow transplantation: Assessing cardiac complications and survival outcomes in the modern era
Abstract Purpose/Objectives:QT interval prolongation is clinically relevant due to increased risk of sudden cardiac death from Torsades de P...
Effect of duffy status on patients with breast cancer receiving cyclin-dependent kinase 4/6 inhibitors
Abstract Purpose: To improve clinical decision-making in patients with breast cancer receiving CDK 4/6 inhibitors, we examined Duffy status...
Single cell protein interactomes by the proximity network assay
Abstract Cellular function depends on dynamic interactions and nanoscale spatial organisation of proteins. While transcriptomic and proteomi...
Phase ib study to assess the efficacy and safety of epcoritamab in relapsed or refractory post-transplant lymphoproliferative disorder
Abstract Background Post-transplant lymphoproliferative disorders (PTLD) represent a heterogeneous group of immune-deficiency related lympho...
Long-term outcomes of syngeneic transplantation in multiple myeloma: Valuable legacy or obsolete option? a study from the chronic malignancies working party of the EBMT
Abstract Background: High-dose chemotherapy with melphalan followed by autologous hematopoietic cell transplantation (auto-HCT) remains the...
The role of hypomethylating agents and venetoclax combination in higher risk myelodysplastic syndromes
Abstract Introduction The topline results from the randomized phase 3 VERONA trial evaluating venetoclax in combination with azacitidine for...
Rituximab beats the odds in ITP? a 5-year national showdown against TPO-ras
Abstract Background The two commonly used second-line strategies for Immune thrombocytopenia (ITP) include rituximab, an anti-CD20 monoclona...
National trends in deep vein thrombosis (DVT) hospitalizations: Comparing in-hospital outcomes in patients with versus without lymphoma (2016-2022)
Abstract Introduction: Deep vein thrombosis (DVT) is a potentially life-threatening complication in patients with cancer. Among cancers, lym...
Superior real-world outcomes of lisocabtagene maraleucel in chronic lymphocytic leukemia
Abstract Introduction: Lisocabtagene maraleucel (liso-cel) was approved in the United States for the treatment of CLL in 3/2024 for patients...
Dynamic evolution of minimal residual disease and normal plasma cells following autologous stem cell transplantation in multiple myeloma
Abstract High-dose melphalan followed by autologous stem cell transplantation (ASCT) has became a cornerstone of standard therapy for newly...
Single-cell analysis and functional profiling reveal galectin-3–driven reprogramming of the tumor immune microenvironment in transformed follicular lymphoma
Abstract Background: Histological transformation of follicular lymphoma (tFL) represents an aggressive subtype characterized by a complex an...
Hodgkin lymphoma-driven hemophagocytic lymphohistiocytosis (HLH) in a predominantly hispanic cohort: A multicenter analysis of clinical features and treatment outcomes
Abstract Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome characterized by profound i...
Artificial intelligence‑driven virtual tumor board enhances precision care in Acute Myeloid Leukemia (AML)
Abstract Background and Aims Acute Myeloid Leukemia (AML) presents significant diagnostic and therapeutic challenges due to rapidly evolving...
The CD33 SNP rs3865444 modulates the association of clonal hematopoiesis with Alzheimer's disease
Abstract Introduction: Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of several age-related pr...
Safety and efficacy of blinatumomab for EBV viremia and PTLD following allogeneic hematopoietic stem cell transplantation
Abstract Background The incidence of Epstein-Barr virus (EBV) reactivation after allogeneic hematopoietic stem cell transplantation (allo-HS...
From co-occurrence to mutual exclusivity: Long read single-cell rnaseq atlas of healthy human bone marrow unveils RNA isoform landscape
Abstract Hematopoietic cell types achieve distinct functions despite sharing the same genome, in part through the expression of alternative...
Pociredir, a novel oral once-daily fetal hemoglobin inducer: Results from the Phase 1b pioneer study in adult participants with severe sickle cell disease and hydroxyurea intolerance or unresponsiveness
Abstract Introduction. Increased expression of fetal hemoglobin (HbF) can counteract hemoglobin S polymer formation in sickle cell disease (...
Trends in mortality from thrombotic microangiopathies with underlying cardiovascular comorbidities as a contributing cause in the United States (1999–2020)
Abstract Background: Thrombotic microangiopathies (TMAs) are life-threatening disorders often complicated by cardiovascular comorbidities. D...
First-in-human phase I trial combining radiopharmaceutical therapy (RPT) using a 90y-anti-CD25 monoclonal antibody (Mab) with total marrow and lymphoid irradiation (TMLI) in relapsed or refractory (R/R) acute leukemia
Abstract Purpose: Patients with R/R acute leukemia who undergo allogeneic hematopoietic cell transplantation (alloHCT) have a dismal prognos...
Real-world characteristics, treatment modifications, and outcomes for patients with Acute Myeloid Leukemia (AML) receiving hypomethylating agents (HMA) + venetoclax (VEN) as first-line treatment (1L)
Abstract Background: Older patients with acute myeloid leukemia (AML), those with multiple comorbidities, and/or poor performance status are...