Blood
Articles in this Issue
Incidence of bleeding and hypertension in patients with hematologic malignancies treated with next-generation Bruton tyrosine kinase (BTK) inhibitors: A meta-analysis of randomized controlled trials
Abstract Background: Bruton tyrosine kinase inhibitors (BTKis) have transformed the treatment landscape for B-cell malig...
Phylogenetic reconstruction reveals early divergence and late expansion of focal lesions in multiple myeloma
Abstract Introduction: During the precursor stages of multiple myeloma (MM), clonal plasma cells typically infiltrate the bone marrow (BM) i...
Multicenter phase 2 study of subcutaneous isatuximab plus bortezomib , lenalidomide and dexamethasone (Isa Sc-VRd) in transplant ineligible newly diagnosed multiple myeloma: Final analysis of the isasocut study (IFM 2022-05)
Abstract Introduction: Isa-VRd has emerged as a new standard of care (SOC) in NDMM TI based on the BENEFIT and IMROZ studies. A subcutaneous...
Concomitant use of venetoclax 100 mg and ketoconazole, a strong CYP3A4 inhibitor, is clinically equivalent to venetoclax 400 mg for treating relapsed or refractory chronic lymphocytic leukemia (CLL): A real-world analysis from the brazilian CLL registry.“
Abstract Background: Venetoclax is a selective BCL-2 inhibitor that has demonstrated significant efficacy in chronic lym...
In Vivo postnatal loss of mature osteoblasts creates an immunosuppressive bone marrow microenvironment to permit the engraftment and proliferation of myeloma cells
Abstract Osteolineage cells are versatile regulators of hematopoietic cells, including providing niches for quiescence and lineage commitmen...
Disparities in survival and therapy access in AYA acute lymphoblastic leukemia: A real-world analysis of social determinants in a low- and middle-income country
Abstract Background: Health disparities in low- and middle-income countries may impact access to care and survival in patients with acute ly...
Mechanism of acquired resistance to histone deacetylase inhibitor, romidepsin, in myeloid leukemia associated with down syndrome
Abstract Acquired resistance is one of the major limitations to improving patient outcomes. Enhancing the clinical efficacy of treatments re...
“trends in anemia and chronic lower respiratory diseases related mortality (1999-2023): A CDC wonder database analysis.”
Abstract INTRODUCTION Anemia and chronic lower respiratory diseases (CLRD) are highly co-occurring conditions that increase the risk of mort...
Safety and efficacy of glofitamab in combination with lenalidomide in relapsed or refractory central nervous system lymphoma: Real-world data
Abstract Background: Central nervous system lymphoma (CNSL) is a rare and aggressive subtype of non-Hodgkin lymphoma, predominantly diffuse...
Impact of venous thromboembolism on clinical outcomes in patients with brain cancer: A national inpatient sample analysis from 2018-2020
Abstract Background: Venous thromboembolism (VTE) is a common and serious complication in brain cancer patients, associated with increased m...
Investigating patients' experiences with dyspnea associated with warm antibody hemolytic anemia (wAIHA) and cognitive debriefing of the FACIT-dyspnea 10 item short form: A qualitative patient interview study
Abstract Introduction:Dyspnea is considered a prominent symptom in patients with warm autoimmune hemolytic anemia (wAIHA). However, there is...
Timed PD-1 blockade synergizes with IL-7/CCL19 armoring to reverse CAR-T exhaustion in PD-L1-high large B-cell lymphoma
Abstract CAR-T cell therapy targeting CD19 has transformed the treatment landscape for relapsed or refractory large B-cell lymphoma (R/R LBC...
Clinical and molecular characteristics of Philadelphia chromosome positive B-cell precursor acute lymphoblastic leukemia with central nervous system relapse versus systemic relapse: Results from consortium on myeloid malignancies and neoplastic diseases (COMMAND)
Abstract Introduction: Clinical outcomes for patients (pts) with Philadelphia chromosome positive (Ph+) B-cell precursor Acute Lymphoblastic...
Longitudinal trends (1999–2023) and forecasted mortality (2024–2030) in sepsis-associated mortality among patients with Myelodysplastic Syndromes in the United States.
Abstract Background: Myelodysplastic Syndromes (MDS) are clonal hematopoietic neoplasms that lead to dysplasia and ineffective hematopoiesis...
The impact of cytokine release syndrome on survival following allogeneic stem cell transplantation with post transplantation cyclophosphamide: Insights from real-world data
Abstract Background: Graft-versus-host disease (GvHD) prophylaxis following stem cell infusion is critical in the success of allogeneic stem...
Distance to specialized care predicts emergency department, pain infusion clinic, and inpatient utilization patterns in adults with sickle cell disease
Abstract Background: Adults with sickle cell disease (SCD) often experience fragmented or crisis-driven care. While geographic distance from...
Real-world treatment patterns and outcomes in frail and non-frail patients with newly diagnosed multiple myeloma not undergoing frontline transplant: A study using cota oncology database
Abstract Background: Multiple myeloma (MM) is commonly diagnosed at older age, when concerns about treatment tolerability often limit the us...
Distinctive features of patients with MPN during pregnancy: Thrombotic risk, molecular drivers, and differential outcomes by subtype
Abstract Introduction: Ph-negative myeloproliferative neoplasms (MPNs), particularly essential thrombocythemia (ET) and polycythemia vera (P...
Interrogation of a large clinical data cohort derived from a comprehensive panheme NGS-based assay for elucidation into MDS risk stratification, impact of chip on disease, biopsy sensitivity, and MRD evaluation
Abstract Myeloid and lymphoid malignancies consist of a heterogenous population of neoplasms, all of which contain distinct genomic alterati...
Cardioprotection without risk? meta-analysis of prophylactic agents in low-risk cancer patients on anthracyclines
Abstract Background Anthracyclines are essential treatments for various cancers but can cause significant, potentially i...
A clinical overview of infection in patients receiving elranatamab (ELRA) in combination with daratumumab (DARA) and lenalidomide (R) for newly diagnosed multiple myeloma in the MagnetisMM-6 trial
Abstract Background MagnetisMM-6 (NCT05623020) is an open-label, 2-arm, randomized, phase 3 study evaluating ELRA in combination with DARA a...
Autoimmune hemolytic anemia with an initially negative direct antiglobulin test: A diagnostic challenge
Abstract Background:Autoimmune hemolytic anemia (AIHA) is a clinical condition characterized by an autoimmune destruction of red blood cells...
Therapeutic ANC attainment during maintenance chemotherapy for pediatric acute lymphoblastic leukemia
Abstract Introduction: Acute Lymphoblastic Leukemia (ALL) is the most common pediatric malignancy. Pediatric ALL treatment requires a mainte...
Application and challenges of the sickle cell outcome grading system (SCOGS) for classifying acute chest syndrome severity
Abstract Introduction: As a leading cause of hospitalization and mortality in sickle cell disease, acute chest syndrome (ACS) presents with...
Bromodomain and extra-terminal domain (BET) as a therapeutic target in a mouse model of secondary hemophagocytic lymphohistiocytosis (HLH)
Abstract Introduction. Secondary hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening inflammatory syndrome triggered by aut...