Blood
Articles in this Issue
Comparative efficacy and safety of obinutuzumab- versus rituximab-based immunochemotherapy in newly diagnosed burkitt lymphoma: A single-center retrospective study
Abstract Background: Burkitt lymphoma (BL) is a highly aggressive B-cell malignancy requiring intensive immunochemotherapy. While rituximab(...
Efficacy and safety of zanubrutinib combined with chemotherapy in the treatment of relapsed/refractory diffuse large B-cell lymphoma
Abstract Background Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. Approximately 30%-40% of patients...
Acquired Hemophilia A (AHA) associated with monoclonal gammopathy: A single institution case series
Abstract Case 1: A 68-year-old woman with IgA lambda monoclonal gammopathy of undetermined significance (MGUS) and beta...
The efficacy of short-course blinatumomab immunotherapy as a bridge-to-HSCT in ph-negative B-cell acute lymphoblastic leukemia
Abstract Introduction Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) provides a potential cure for patients with Ph...
Germline genetic testing uncovers a high frequency of inborn error of immunity diagnoses in children with single and multi-lineage immune cytopenias in a large US cohort
Abstract Background Immune cytopenias including Immune Thrombocytopenia (ITP), Autoimmune Hemolytic Anemia (AIHA), or multilineage immune cy...
Chorionic villus sampling acceptability and therapeutic abortion compliance in beta-thalassemia minor parents: A study in low-middle income country
Abstract Introduction: Beta-thalassemia is the most prevalent hemoglobin disorder in Pakistan, posing a significant disease burden. Prenatal...
Overlap of post-CAR T HLH toxicity definitions and their prognostic significance in children and young adults with B-acute lymphoblastic leukemia
Abstract Introduction: Hemophagocytic lymphohistiocytosis (HLH) toxicities are increasingly recognized following chimeric antigen receptor (...
Functional annotation of MPN clones reveals mutation-specific fitness and fate bias
Abstract Introduction Improving outcomes for patients with myeloproliferative neoplasms (MPNs) requires therapies that prolong event-free sur...
Quality and timing of patient-reported outcome reports in randomized controlled trials (RCTs) of patients with lymphoid malignancies: Analysis of 83 RCTs published between 2015 and 2025
Abstract Background Patient-Reported Outcomes (PROs), including quality of life or symptoms, are now frequently used as endpoints in RCTs te...
Mitochondria contribute to naip/NLRC4 inflammasome assembly and activation in macrophage
Abstract Macrophages play a crucial role in both innate immunity and inflammation. The NAIP/NLRC4 inflammasome is an imm...
High dose ascorbate downregulates innate immune cytokines in the bone marrow of TET2 mutant chronic myelomonocytic leukemia
Abstract The most frequent mutation in CMML is a loss of function missense or frameshift variant in the gene encoding the epigenetic dioxyge...
CPX-351 is effective in secondary Acute Myeloid Leukemia, regardless if defined according to 2016 or 2022 edition of who classification.
Abstract Background and aims: The definition of secondary Acute Myeloid Leukemia (s-AML) has significantly changed from the previous WHO cla...
Effects of vaso-occlusive episodes, acute kidney injury, and APOL1 status on urine albumin concentration in patients with sickle cell disease
Abstract Introduction: Chronic kidney disease (CKD) is a common complication associated with substantial morbidity and early mortality in pe...
Safety and efficacy of the JAK/rock inhibitor rovadicitinib in combination with the bromodomain and extra-terminal inhibitor TQB3617 in patients with myelofibrosis: A phase ib/II study
Abstract Introduction: Rovadicitinib (R, TQ05105) is a novel, oral small-molecule JAK/ROCK inhibitor that has demonstrat...
Risk factors for thrombo-embolism in neonates: A systematic review of the literature and call to action
Abstract BACKGROUND: While venous thrombo-embolism (VTE) is increasingly recognized in neonates and prothrombotic risk factors are increasin...
Fucosylation of human hematopoietic stem cells enhances engraftment and self-renewal through modulated e-selectin interactions and intracellular signaling
Abstract Hematopoietic stem cell transplantation (HSCT) efficacy is often limited by inefficient stem cell delivery to the bone marrow and c...
Sequencing CD20-directed bispecific antibody and CD19-directed CAR T cell therapy in large B cell lymphoma: A multicenter real-world study
Abstract Introduction Multiple T-cell engaging therapies, including CD20-directed bispecific antibodies (BsAb) and CD19-directed chimeric ant...
Comparative analysis of mortality trends in acute versus chronic lymphoid leukemia in the u.S. population: A CDC wonder-based study (1999–2023).
Abstract Introduction: Lymphoid leukemia, having acute(ALL) and chronic(CLL) forms, is a malignancy of the blood and bone marrow that disrup...
Targeting CPNE8 suppresses HOXA9-dependent AML progression and overcomes chemotherapy resistance
Abstract Background Acute myeloid leukemia (AML) remains a challenge in treatment and mechanisms understanding in disease progression and th...
Racial disparities on incidence and survival in Mantle Cell Lymphoma: A surveillance, epidemiology and end results program database (2013-2022) retrospective analysis
Abstract Background: Mantle cell lymphoma (MCL) is a rare and aggressive subtype of B-cell non-Hodgkin lymphoma, accounting for approximatel...
Synthetic lethal targeting of PSMC2-dependent p97-adapted proteasome complexes that confer chemoresistance in multiple myeloma
Abstract Introduction. Multiple myeloma (MM) is the second most common hematological malignancy. The emergence of novel agents has significa...
A decade of progress: A comparative analysis of real-world survival in chronic lymphocytic leukemia across therapeutic eras
Abstract Introduction Management of chronic lymphocytic leukemia (CLL) has advanced significantly over the past two decades with the introduc...
Apcin-derived CDC20 inhibitors synergize with microtubule disruptors to induce mitotic catastrophe in acute leukemias
Abstract CDC20, a coactivator of the Anaphase-Promoting Complex/Cyclosome (APC/C), is a key regulator of chromosome segregation and mitotic...
Advancing strategies to improve chemotherapy adherence in young children with ALL: Understanding the role of behavioral parenting skills and daily barriers to identify novel intervention targets
Abstract Introduction: Adherence to oral anti-cancer therapies is a critical concern in pediatric oncology, and studies consistently documen...
Elevated circulating activated FOXP3+ regulatory T cell subset in patients with advanced chronic lymphocytic leukemia as a marker for severe infections during 1000 days of follow-up
Abstract Introduction. Patients with chronic lymphocytic leukemia (CLL) are more susceptible to infections, which remain the leading cause of...