Blood
Articles in this Issue
Development of ALK-directed TCR-T cells with potent and specific anti-tumor activity against ALK-positive anaplastic large cell lymphoma
Abstract Introduction: Anaplastic Lymphoma Kinase (ALK)-positive Anaplastic Large Cell Lymphoma (ALCL) is a subtype of T-cell lymphoma repre...
Integrated clinical and radiomic PET-FLIPI score for risk stratification in newly diagnosed follicular lymphoma
Abstract Background: Follicular lymphoma (FL) has a heterogeneous clinical course, and despite advances in therapy, a significant proportion...
Treatment responses and survival of newly diagnosed older or unfit patients (pts) with IDH1/2-mutated Acute Myeloid Leukemia (AML): An analysis of the MARROW consortium
Abstract Background: The discovery of IDH1/2 mutations in AML has resulted in FDA approving therapies targeting IDH1/2. Similarly, the chang...
Nemtabrutinib plus venetoclax in relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma: Results from the dose escalation and confirmation segment of the Phase 3 bellwave-010 study
Abstract Introduction: Venetoclax + rituximab (VR) is a standard-of-care therapy for patients with relapsed or refractory (R/R) chronic lymp...
Self-reported prophylaxis treatment experience among persons living with hemophilia A in the US: A cross-sectional analysis of survey results combined with medical records
Abstract Background: In hemophilia A (HA), prophylaxis is used to prevent bleeding and joint damage. With the expansion of non-factor therap...
Representativeness of clone size measurement by using NGS-based immunoglobulin gene rearrangement test in comparison to flow cytometry in clonal plasma cell disorders
Abstract Introduction: Next-generation sequencing (NGS) IG gene rearrangement test provides quantitative information about the clone, which...
Enhancing the expansion of Naïve, potent T-cells via BTK inhibition reinvigorates CD19-CAR T-cell immunity and boosts antitumor efficacy in relapsed Mantle Cell Lymphoma
Abstract Background Emerging evidence indicates that inhibition of BTK and tyrosine kinases enhances immune responses and potentiates CAR T-...
Impact of inhibitors positivity on treatment patterns and disease burden in Chinese patients with hemophilia: A cross-sectional real-world study
Abstract Hemophilia is an X-linked inherited bleeding disorder characterized by a deficiency of coagulation factor VIII or IX, leading to re...
Immunogenicity assessment of concizumab in patients with Hemophilia A and b: Assays developed to measure anti-drug antibodies and integrated results from clinical trials
Abstract Background Concizumab is an anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody indicated for patients with hemophilia...
Venetoclax in combination with hypomethylating agents shows promising activity in Acute Myeloid Leukemia with late relapse post allogeneic stem cell transplant: From the EBMT acute leukemia working party
Abstract Introduction Allogeneic hematopoietic stem cell transplantation (HSCT) remains a mainstay in the treatment of acute myeloid leukemi...
Inotuzumab ozogamicin vs blinatumomab bridging optimization and second CD19 CAR-T efficacy in Relapsed/Refractory B-ALL
Abstract Introduction: Despite advances with CD19 chimeric antigen receptor T-cells (CAR-T) in relapsed/refractory B-cel...
Clinical impact of delays in insurance authorization for newly diagnosed Acute Myeloid Leukemia considered for intensive induction chemotherapy
Abstract Introduction: Expert guidelines recommend investigational therapy as first-line treatment for many patients with acute myeloid leuk...
Study on five-year continuous improvement path for perianal infection prevention and control in hematopoietic stem cell transplantation Patients—Achieving zero infection through data-driven and optimized nursing schemes
Abstract Perianal infection is common in HSCT patients. Due to mucosal barrier damage and severe immunosuppression from conditioning regimen...
Identifying high-risk profiles and adverse prognoses in relapsed/refractory multiple myeloma treated with bispecific antibodies: A real-world analysis of 943 treatment initiations
Abstract Introduction: Bispecific T-cell engagers (TCE) targeting BCMA (teclistamab, elranatamab) and GPRC5D (talquetamab) are important ther...
Epidemiology and outcomes of patients with myeloproliferative neoplasms in the United States: A SEER database analysis, years 2000-2021
Abstract Background: Classic MPNs include Essential Thrombocythemia (ET), Polycythemia Vera (PV), Primary Myelofibrosis (PMF), and Chronic M...
A multi-timepoint immune profiling model for differentiating gvhd- and infection-associated diarrhea following allo-HSCT
Abstract Introduction Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for various hematologic malignanc...
Autologous CD30.CAR-T-cell therapy in patients with relapsed or refractory classical Hodgkin lymphoma – long term update of the chariot trial
Abstract Introduction Autologous CD30-directed chimeric antigen receptor T-cell (CD30.CAR-T) therapy has demonstrated fa...
Primary results from Equator, a Phase 3 double-blind, randomized placebo-controlled study evaluating itolizumab in combination with corticosteroids as initial treatment of acute graft-versus-host disease.
Abstract Introduction: Itolizumab is a non-depleting, monoclonal antibody against CD6 that blocks its interaction with activated leukocyte c...
Functional difference of CAR T-cells prepared from peripheral stem cell collections and peripheral lymphocyte collections
Abstract Introduction: CAR T-cell immunotherapy involves the collection of T cells, followed by ex vivo genetic modification, expansion, and...
Single-cell transcriptomics reveal mechanisms of efficacy and toxicity in anti-BCMA CAR-T cell therapies for multiple myeloma
Abstract Introduction Anti-B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T cell therapies, including FDA-approved ciltaca...
A practical tool for predicting outcomes in essential thrombocythemia: Triple (or quadruple) a risk model
Abstract Introduction: Essential thrombocythemia (ET) is generally an indolent disease, but it can be complicated by thrombosis, bleeding, pr...
Patient-reported outcomes from dreamm-7 and dreamm-8 using the EQ-5D-3L, patient global impression of severity, and patient global impression of change
Abstract Background: In DREAMM-7 (NCT04246047), belantamab mafodotin (belamaf) in combination with bortezomib and dexamethasone (BVd) demons...
Implementation of a multidisciplinary quality improvement project standardizing an approach to screening and treating iron deficiency in pregnancy
Abstract Introduction: Iron deficiency (ID) is a global epidemic with discrepant definitions of both ID and anemia in pregnancy. Iron requir...
Three-year follow-up of the Phase 1 first-in-human study investigating surovatamig, a novel CD19xCD3 T-cell engager, in patients with Relapsed/Refractory (R/R) follicular lymphoma (FL)
Abstract Introduction: Surovatamig (formerly AZD0486) is a novel, IgG4 fully human CD19xCD3 bispecific T-cell engager (TCE) being evaluated...
Establishment and validation of an optimized prognostic model for Chinese patients with chronic myelomonocytic leukemia (Sino-CPSS): A 231-patient single-center study
Abstract Background: Chronic myelomonocytic leukemia (CMML) exhibits significant survival heterogeneity. Existing prognostic models based on...