Blood
Articles in this Issue
Understanding secondary immunodeficiency management in patients with hematological malignancies
Abstract Background: Secondary antibody deficiency (SAbD) is a prevalent immune disorder characterized by impaired specific antibody product...
Improving outcomes with nivolumab consolidation among older patients (≥65) with previously untreated primary CNS lymphoma
Abstract Introduction: Autologous stem cell transplant (ASCT) is widely accepted as the standard consolidation therapy for primary CNS lymph...
Integrating palliative care for adolescents and young adults with hematologic malignancies: Insights from a dedicated french unit.
Abstract Context. The outcome of adolescents and young adults (AYA) aged 15 to 25 with cancer has improved, with five-year survival rates no...
Development of a machine learning model to predict overall survival in patients with peripheral T-cell lymphoma in a minority enriched population
Abstract Introduction: Peripheral T-cell lymphomas (PTCL) are a group of heterogeneous lymphomas that arise from mature T-cells and comprise...
A triple threat to diagnostic safety in CTPA: Diagnostic uncertainty, sspe, and reporting discrepancies
Abstract Background: CT pulmonary angiography (CTPA) is the gold standard for diagnosing pulmonary embolism (PE), yet inconsistencies in rep...
Atypical hemolytic uremic Syndrome Triggered by malignancy and drug exposure: A systematic review and meta-analysis
Abstract Background Atypical hemolytic uremic syndrome (aHUS) is a rare thrombotic microangiopathy driven by complement...
Imputing causality from single-cell transcriptomics in paroxysmal nocturnal hemoglobinuria
Abstract Background Paroxysmal nocturnal hemoglobinuria (PNH) is a rare life-threatening acquired disease, clinically manifest as intravascu...
Synergistic efficacy of EZH2 inhibitor combined with new flavonoid derivatives in AML patient-derived xenograft mouse models
Abstract Introduction: Enhancer of Zeste 2 (EZH2) is the enzymatic subunit of Polycomb Repressive Complex 2 (PRC2) that is highly upregulated...
Mechanisms of immune escape and altered tissue homing in leukemia cutis
Abstract Extramedullary acute myeloid leukemia (eAML) relapse is frequent after allogeneic hematopoietic cell transplantation (HCT), suggest...
A standardized rapid dose escalation of epcoritamab for patients with lymphoid malignancies
Abstract Introduction: Cytokine release syndrome (CRS) is a common adverse event associated with the bispecific antibody (BsAb), epcoritamab...
Updated survival outcomes of pomalidomide/bortezomib/dexamethasone in newly diagnosed multiple myeloma with renal impairment: A prospective, open-label, multicenter, phase 2 study
Abstract BACKGROUND Renal impairment (RI) affects 20-40% of newly diagnosed multiple myeloma (NDMM) patients and independently predicts adve...
Targeted salvage therapy improves survival in B-ALL relapsing after CD19 CAR-T: A multi-institutional study
Abstract Purpose: CD19 chimeric antigen receptor T-cell (CAR-T) therapy demonstrates remarkable efficacy in patients with B-Cell Acute Lymph...
Optimizing skeletal health: An analysis of bone-modifying agent prescription patterns and incidence of skeletal-related events in multiple myeloma
Abstract Introduction Skeletal-related events (SREs) in multiple myeloma (MM) contribute to significant morbidity. Bone-modifying agents (BM...
Real world evidence comparing idecabtagene vicleucel (Ide-cel, Abecma) versus ciltacabtagene autoleucel (Cilta-cel, Carvykti) chimeric antigen receptor T-cell (CART) therapy among patients with Relapsed/Refractory multiple myeloma (RRMM)
Abstract Background: The two commercially available CART constructs targeting BCMA (Ide-cel and Cilta-cel) were approved initially for patie...
The switch of TCA cycle mode determines the fate of pirtobrutinib-tolerant persister cells
Abstract Background Drug-tolerant persister (DTP) cells are increasingly recognized as a key contributor to therapy resistance in cancer pat...
Safety and efficacy of carniospinal irradiation (CSI) before CAR T cell therapy in patients with acute lymphoblastic leukemia (ALL) with central nervous system (CNS) disease: A potential role for CSI beyond cell killing and into immune priming
Abstract Background: Outcomes of patients (pts) with B-cell acute lymphoblastic leukemia (B-ALL) have improved significantly with the introdu...
Clinical features and outcomes of myelofibrosis patients with MPL mutations
Abstract Background Myelofibrosis (MF) is a type of myeloproliferative neoplasm (MPN) characterized by clonal proliferation of hematopoietic...
Enhanced clinical and systemic response with combination radiation therapy and topical imiquimod in mycosis fungoides: A pilot study
Abstract Introduction: Mycosis fungoides (MF), the most prevalent type of cutaneous T-cell lymphoma (CTCL), presents significant therapeutic...
Unravelling the biological and clinical features of childhood B-cell precursor acute lymphoblastic leukemia with monosomy 7
Abstract Monosomy of chromosome 7 is a common cytogenetic aberration predicting prognosis in myeloid malignancies and promoting transformati...
Real-world treatment patterns and survival outcomes in primary CNS lymphoma: Analysis of the national cancer database
Abstract Background Primary central nervous system lymphoma (PCNSL) is a rare but aggressive non-Hodgkin lymphoma with limited prospective d...
Age-associated non-mutational resistance in acute myeloid leukemia is driven by DNA damage-induced transcriptional heterogeneity
Abstract Older patients with acute myeloid leukemia (AML) have significantly worse response rates and overall survival compared to younger p...
Meteorological impact on ventricular arrhythmias in sickle cell disease
Abstract Background: Patients with sickle cell disease (SCD) are known to have a heightened burden of ventricular ectopy, yet the contributi...
In Vivo generation of anti-CD19 CAR-T cells for the treatment of B-cell mediated autoimmune diseases
Abstract Emerging clinical data demonstrate the transformative potential of B cell-depleting CAR-T therapies for patients with autoimmune di...
Single-cell profiling of natural killer T-cell lymphoma reveals stratified immune features and therapeutic strategies
Abstract Background :Natural killer T-cell lymphoma (NKTCL) is a rare subtype of non-Hodgkin lymphoma (NHL) characterized by rapid progressio...
Warm autoimmune hemolytic anemia following epstein-barr virus reactivation: An uncommon clinical association
Abstract Introduction: Autoimmune hemolytic anemia (AIHA) is a rare condition characterized by the immune system's destruction of red blood...