Blood
Articles in this Issue
Sustainability and cost-avoidance of reduced inappropriate red cell transfusion at community hospitals in niagara region: A follow-up analysis on a quality improvement initiative.
Abstract Introduction: Red blood cell transfusions (RBC) are a vital component of medical treatment in Canada. Yet, RBC units are expensive...
Nuvisertib, an oral investigational selective PIM1 kinase inhibitor, showed clinical responses strongly correlating with cytokine modulation in patients with relapsed/refractory myelofibrosis in the ongoing global phase I/II study
Abstract Background: PIM1 is overexpressed in hematologic malignancies, including myelofibrosis (MF), contributing to disease progression by...
Real-world experience of efanesoctocog alfa in Hemophilia A patients in the US: A retrospective analysis
Abstract Introduction Efanesoctocog alfa is a first-in-class, high-sustained factor VIII (FVIII) replacement therapy designed to overcome th...
Dexamethasone, Rituximab and Cyclophosphamide with Bortezomib is a rapidly acting and highly efficient first-line treatment in Waldenström's Macroglobulinemia: Final analysis of ECWM-1 trial of the European Consortium for Waldenström's Macroglobulinemia (ECWM)
Abstract Beside Rituximab-Bendamustine, the Dexamethasone, Rituximab and Cyclophospamide (DRC) regimen is still one of the most frequently u...
Q- hemegenome: The Qatar national registry for germline predisposition to myeloid and other hematologic malignancies
Abstract Background Recognition of germline predisposition to myeloid and other hematologic malignancies has increased substantially in rece...
Machine learning replicates and extends clinician-informed disease severity grading classification for acute pain and CKD in sickle cell disease
Abstract Acute pain and chronic kidney disease (CKD) are two of the most serious and phenotypically variable complications in sickle cell di...
Enteral supplementation with a TGF-β-enriched polymeric diet mitigates gastrointestinal acute gvhd
Abstract Gastrointestinal acute graft-versus-host disease (GI-aGVHD) is a major contributor to non-relapse mortality after allogeneic hemato...
Reveal-MM: Retrospective evaluation of variables in early assessment and landmark trends in multiple myeloma – a US claims-based case-control study
Abstract Introduction Multiple myeloma (MM) presents with non-specific symptoms, often leading to diagnostic delays or mis-referrals to vari...
Proportion of second hematologic malignancies linked to radiotherapy treatment in adults: A cohort study in the US SEER cancer registries 2001-2022
Abstract Introduction: Radiotherapy is a cornerstone of cancer treatment, known to improve local tumor control and survi...
Administration- and adverse event-related costs among patients with multiple myeloma treated with B-cell maturation antigen (BCMA)-targeted agents
Abstract Introduction: Costs associated withadministration and adverse events (AEs) are important considerations in budget impact models (BI...
Integrative surfaceome mapping in AML identifies CD85d as an immunotherapy target
Abstract Adoptive immunotherapies have transformed the treatment landscape for several hematologic malignancies, yet their clinical impact i...
Emapalumab induces rapid, durable responses and reliable bridging to curative HSCT in patients with primary HLH: Pooled analysis of prospective trials NI-0501-04, NI-0501-05 and NI-0501-09
Abstract Introduction: Primary hemophagocytic lymphohistiocytosis (pHLH) is a life-threatening, genetically driven, interferon-γ (IFNγ)–medi...
Association between absolute eosinophil count and outcomes in sickle cell disease
Abstract Objective: Patients with sickle cell disease (SCD) may experience vaso-occlusive episodes (VOE) requiring hospitalization. Studies...
The oral PI3Kdelta inhibitor Linperlisib and Obinutuzumab as response-dependent, first-line regimen for marginal zone lymphoma: A prospective single-arm Phase Ib/II Study
Abstract Introduction Indolent non-Hodgkin lymphomas, such as marginal zone lymphoma (MZL), typically follow an indolent course and are asso...
Role of the immune microenvironment in the clonal evolution of chronic lymphocytic leukemia
Abstract Background: Chronic lymphocytic leukemia (CLL) is a heterogeneous B-cell malignancy characterized by clonal exp...
Survival outcomes of adolescents and young adults with lymphoblastic lymphoma treated with pediatric-inspired protocols in the Middle East
Abstract Lymphoblastic lymphoma (LBL) is a highly aggressive neoplasm of precursor lymphoid cells, accounting for approximately 2% of all no...
Haploidentical hematopoietic stem cell transplantation with bussulfan, fludarabine and cyclophosphamide and total body irradiation 200cgy conditioning with post-transplant cyclophosphamide and peripheral blood stem cells as an alternative regimen to reduce graft rejection in sickle cell disease
Abstract Background: Sickle cell disease (SCD) is a hereditary hemoglobinopathy affecting millions worldwide, characterized by chronic hemol...
ATR inhibition with nucleoside analog therapy synergistically overcomes chemoresistance and reprograms dark zone lymphomas toward immune-accessible phenotypes
Abstract Introduction: Dark zone-like diffuse large B-cell lymphoma (DZ-DLBCL) represents a distinct germinal center B-cell (GCB) subtype, c...
Autophagy/lysosome disruption via pikfyve inhibition in multiple myeloma
Abstract We previously reported achemo-genomics screen that unexpectedly identified phosphatidylinositol-3-phosphate 5 kinase (PIKfyve) as a...
Real‑world effectiveness and patient-centered outcomes of fixed‑duration vs continuous first‑line therapy in chronic lymphocytic leukemia (CLL)
Abstract Background: The treatment landscape of chronic lymphocytic leukemia (CLL) has shifted with the adoption of targeted therapies admin...
TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated Acute Myeloid Leukemia
Abstract Mutations in nucleophosmin (NPM1) are identified in 35% of acute myeloid leukemia (AML) patients, but therapeutic strategies target...
Pentostatin/TBI conditioning for allogeneic transplantation in T-cell lymphomas
Abstract Background: Aggressive T-cell lymphomas are rare, biologically heterogeneous malignancies with a poor prognosis in the relapsed or...
Impact of pre-existing cardiovascular disease on inpatient arrhythmias following autologous stem cell transplantation in multiple myeloma: A national inpatient sample database analysis
Abstract Introduction: Autologous stem cell transplantation (ASCT) continues to be a cornerstone in the treatment of eligible patients with m...
Multicenter, randomized Phase II study of epcoritamab for patients with large B-cell lymphomas achieving a partial response after CD19-directed CAR T-cell therapy: Trial in progress
Abstract Background: Despite the promising efficacy of CAR-T for patients with relapsed or refractory (R/R) large B-cell lymphomas (LBCL), mo...
Hematopoietic stem cell transplantation for relapsed classical Hodgkin lymphoma: A benchmark Study on 19,498 patients from the EBMT lymphoma working party
Abstract Introduction: Autologous hematopoietic stem cell transplantation (auto-HSCT) remains a standard of care for patients with chemosens...