Blood
Articles in this Issue
Suboptimal cancer-screening adherence in CLL/SLL patients
Abstract Background: Patients diagnosed with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) have an i...
A novel LRF degrader induces fetal hemoglobin expression in adult erythroblasts
Abstract Elevating fetal hemoglobin (HbF) represents a validated therapeutic strategy for sickle cell disease (SCD) and β-thalassemia. Hydro...
Proteomics reveals COX7B as a prognostically relevant oxphos-linked protein in pediatric AML
Abstract Introduction: Acute myeloid leukemia (AML) is a complex and highly heterogeneous hematologic malignancy with poor clinical outcomes...
The utility of CT sinus screening in the pre-bone marrow transplant evaluation
Abstract Background: Patients undergoing allogeneic bone marrow transplantation (BMT) are immunocompromised due to prolonged myelosuppressio...
Efficacy and safety profile of inaticabtagene autoleucel in Chinese adult patients with B-cell acute lymphoblastic leukemia who relapsed after their transplant: Insights from real-world data
Abstract Introduction Limited therapeutic options are available for adult patients with B-cell acute lymphoblastic leukemia (B-ALL) who rela...
Restoring hematopoiesis after low dose decitabine of poor graft function post allogenic hematopoietic stem cell transplantation
Abstract Introduction: Poor graft function (PGF), characterized by pancytopenia, is an intractable complication following allogeneic hematop...
Real-world outcomes of eltrombopag-containing regimens as frontline treatment for aplastic anemia: A multi-center retrospective study
Abstract Background Eltrombopag (EPAG), an oral thrombopoietin receptor agonist, has emerged as a promising frontline treatment for aplastic...
Suppressive dexamethasone (SupDex) to prevent delayed non-icans delayed neurotoxicity (DNT) post ciltacabtagene-autoleucel(cilta-cel) in patients with relapsed myeloma.suppressive dexamethasone (SupDex) to prevent delayed non-icans delayed neurotoxicity (DNT) post ciltacabtagene-autoleucel(cilta-cel) in patients with relapsed myeloma.
Abstract Introduction: Cilta-cel has demonstrated unprecedented efficacy for multiple myeloma. However, DNTs, mainly in the form of cranial...
Risk of therapy-related acute lymphoblastic leukemia (t-ALL) in cancer patients secondary to either chemotherapy, radiation, or both: A retrospective cohort study from 1975-2021 using SEER registry
Abstract Background: The incidence of therapy-related leukemias is exponentially increasing with the widespread use of c...
Triple-negative myeloproliferative neoplasms (TN-MPN): A meta-analysis of clinical and molecular characteristics
Abstract Triple-negative myeloproliferative neoplasms (TN-MPN), defined by the absence of canonical driver mutations in JAK2, CALR, and MPL,...
Building healthcare professional capacity in sickle cell disease through a global case-based discussion program
Abstract Background: There is a critical need for specialized training and education to improve clinical outcomes in sickle cell disease (SC...
Elucidating the chronological relationship between central venous line dysfunction, infection and thrombosis in children with cancer: A preliminary analysis
Abstract Background In children with cancer and central venous lines (CVLs), about 31–50% of children experience CVL-rel...
Circulating tumor cells (CTCs) for dynamic risk assessment of patients (Pts) with smoldering multiple myeloma (SMM)
Abstract Background: A single risk assessment using the IMWG 20/2/20 model may be insufficient for individualized management of SMM pts. Ser...
Rising burden of hemophagocytic lymphohistiocytosis in the United States: A nationwide analysis of mortality, disparities, and underdiagnosis
Abstract Title: Rising Burden of Hemophagocytic Lymphohistiocytosis in the United States: A Nationwide Analysis of Morta...
Non-invasive classification & molecular subtyping of mature lymphoid neoplasms by cell-free DNA profiling
Abstract Background: Mature lymphoid neoplasms (MLN) are currently diagnosed by integrating histopathological, immunophenotypic, cytogenetic...
Revumenib for patients with relapsed or refractory (R/R) KMT2Ar acute leukemia: Outcomes by leukemia type in the phase 2 AUGMENT-101 study
Abstract BACKGROUND Patients (pts) with lysine methyltransferase 2A–rearranged (KMT2Ar)acute leukemia (AL) have a poor prognosis. The menin-...
Risk of transfusion associated circulatory overload after blood products transfusion in patients with hfref vs. hfpef: A real-world propensity-matched analysis
Abstract Background: Transfusion Associated Circulatory Overload (TACO) is a serious complication of blood products transfusion, particularl...
Evaluation of the clinical performance of Metagenomic Next-generation sequencing for diagnosis of invasive fungal diseases after CAR-T cells infusion
Abstract Introduction Chimeric antigen receptor T-cell (CAR-T) therapy is highly effective in treating hematological malignancies but increa...
Targeting a novel surface antigen, ryk, with the antibody-drug conjugate, slv-404, is effective in richter transformation patient-derived xenografts
Abstract RYK belongs to the receptor-like tyrosine kinase (RTK) family and plays a role in Wnt canonical and non-canonical pathways. The bes...
Excellent prognosis for adult patients with Philadelphia chromosome-negative ALL with standard genetic risk and EARLY clearance of MRD. sub-analysis of pethema LAL19 trial
Abstract Introduction. Adults with Ph-negative acute lymphoblastic leukemia (Ph- ALL) may not require allogeneic hematopoietic stem cell tra...
Combination of brentuximab vedotin and nivolumab in the management of Hodgkin lymphoma: A systematic review and meta-analysis
Abstract Introduction: Hodgkin lymphoma is a type of cancer that affects the lymphatic system, characterized by the presence of Reed-Sternbe...
Circulating glycornas: A novel class of glycoconjugates in blood and implications for erythrocyte biology
Abstract Background: The discovery of glycoRNAs introduced a groundbreaking paradigm, revealing RNA could be covalently modified with glycan...
Long-term remissions in refractory ITP patients by daratumumab
Abstract Introduction Relapsed or refractory immune thrombocytopenic purpura (ITP) remains a therapeutic challenge in hematology and represe...
“Double trouble: The first reported case of evans syndrome following RSV Vaccination”
Abstract Introduction Evans syndrome is a rare, chronic autoimmune disorder characterized by the simultaneous or sequential occurrence of IT...
Bridging the divide: Meta-analysis of racial disparities in survival and clinical trial participation in Myelodysplastic Syndromes
Abstract Background: Outcomes of Myelodysplastic syndromes (MDS) can be influenced by race, ethnicity, and socioeconomic factors. While indi...