Blood
Articles in this Issue
Golidocitinib combination therapy as first-line treatment in PTCL: Retrospective data from a single centre
Abstract Background: Peripheral T-cell lymphoma (PTCL), except for the anaplastic large cell lymphoma (ALCL) subtype, is characterized by a...
Matched unrelated vs. Haploidentical donor for allogeneic stem cell transplantation in patients with acute leukemia with identical GvHD prophylaxis – a randomized prospective european trial.
Abstract Haplo-identical allogeneic cell transplantation (haploHCT) using post- transplant cyclophosphamide (PTCy) is increasingly used if n...
Novel AML specific splice junction evaluation identifies ubc and DMBT1 as top proteins of clinical and therapeutic relevance in pediatric Acute Myeloid Leukemia
Abstract Introduction: Acute Myeloid leukemia (AML) is a hematologic malignancy characterized by uncontrollable proliferation of myeloid stem...
Mechanism of butyrate remodeled calcium signaling in NK cells reverses daratumumab resistance in multiple myeloma
Abstract Background Daratumumab (Dara), a first-in-class anti-CD38 monoclonal antibody, is pivotal in multiple myeloma (MM) treatment. Never...
Targeting BTKi-resistant CLL using the dual irreversible/reversible 4th generation BTK inhibitor rocbrutinib
Abstract Background: Treatment of CLL has been transformed by targeted therapies including inhibitors of Bruton's tyrosine kinase (BTKi). Cu...
Refined elderly comorbidity index is highly predictive of post-transplant survival in older adults with Acute Myeloid Leukemia and myelodysplastic syndrome
Abstract Background: Allogeneic hematopoietic cell transplantation (HCT) is the only curative option for most adults with acute myeloid leuk...
Neutrophil-lymphocyte and platelet-lymphocyte ratios as predictors of atherosclerotic thrombotic risk in patients with myelofibrosis
Abstract Myelofibrosis (MF) isa chronic myeloproliferative neoplasm associated with risk of atherosclerotic cardiovascular disease (ASCVD),...
Potential paradoxical hemostatic function of ADAMTS13 by enhancing collagen-induced platelet aggregation and activation
Abstract Background: ADAMTS13 is an anti-thrombotic metalloenzyme that cleaves ultra large von Willebrand factor (VWF) released from endothe...
High treatment compliance and tolerability with fitusiran antithrombin-based dose regimen in people with hemophilia A or B, with or without inhibitors: ATLAS-OLE study
Abstract Background Hemophilia A (HB) and B (HB) are rare, inherited bleeding disorders characterized by a deficiency of clotting factors VI...
Toward precision pathology: Deep learning supported fibrosis grading augments performance of international hematopathologists in a large real-world cohort
Abstract Introduction Evaluation of bone marrow fibrosis is essential in the assessment of newly diagnosed hematological...
Burden of Hodgkin lymphoma from 1990 to 2021 and modelled projection to 2050
Abstract Background: Hodgkin lymphoma (HL) represents a significant malignancy, yet comprehensive data on its epidemiological evolution are...
When pregnancy, HIT, and stroke collide: Navigating complex thrombotic care in a community-based setting
Abstract Background: Heparin-induced thrombocytopenia (HIT) is an infrequent but life-threatening complication of heparin exposure, occurrin...
Genetic analysis of B and T cell subsets from CLL patients prior to and at Richter's transformation
Abstract Introduction: A subset of patients with chronic lymphocytic leukemia (CLL) experiences disease progression from CLL to Richter tran...
Short-duration blinatumomab for residual disease eradication as a bridge to transplant in B-ALL: Pediatric and adult outcomes in a resource-limited context
Abstract Background Blinatumomab is considered a standard of care for patients with B-cell acute lymphoblastic leukemia (B-ALL) and measurab...
Early methotrexate level thresholds predictive of acute kidney injury in patients with b cell lymphomas receiving high-dose methotrexate
Abstract Background: Methotrexate (MTX) induced acute kidney injury (AKI) occurs in 9% of patients (pts) receiving high dose (HD) methotrexa...
Asciminib and pregnancy in CML: Preliminary human data and clinical implications from 47 reported outcomes
Abstract Asciminib (ASC) is a first-in-class allosteric BCR::ABL1 tyrosine kinase inhibitor (TKI), specifically targeting the myristoyl pock...
Superior disease-free survival of allogeneic hematopoietic stem cell transplantation in elderly patients with hematological malignancies in complete remission by reduced-intensity or myeloablative conditioning
Abstract Introduction: The prognosis of elderly patients with hematological malignancies by chemotherapy is usually poor. Allogeneic hematop...
Etiologies and clinical predictors of pediatric eosinophilia: A retrospective analysis from a tertiary care center
Abstract Background: Eosinophilia in pediatric patients encompasses a broad spectrum of etiologies, ranging from allergic disorders to hemat...
Fus::ERG fusion represents adverse-plus risk group in AML patients: Evidence from a registry-based matched cohort Study
Abstract Background The Allo-HCT refined ELN 2022 classification identifies Adverse-Plus acute myeloid leukemia (AML) as the highest-risk su...
Effect of prior CD19-directed monoclonal antibody exposure on outcomes in patients subsequently treated with CD19 targeting CAR-T therapy: A multicenter propensity score matched retrospective cohort study
Abstract Background CD19 is a transmembrane glycoprotein expressed throughout B-cell development and is preserved in most B-Cell malignancie...
Anti-platelet factor 4 antibodies in MGUS-related thrombosis
Abstract Introduction: Monoclonal gammopathy of thrombotic significance (MGTS) is a recently recognized thrombophilia where monoclonal plate...
CD62L enrichment achieves robust expansion and memory phenotype post-infusion in patients with LBCL treated with rondecabtagene autoleucel, an autologous, dual-targeting CD19/CD20 CAR T-cell candidate
Abstract Background: Durable complete response remains the therapeutic goal when treating patients with large B-cell lymphoma (LBCL) with ch...
Cardiovascular outcomes of patients transitioned from ibrutinib to an alternate bruton tyrosine kinase inhibitor for hypertension and/or cardiovascular adverse events
Abstract Introduction: Bruton tyrosine kinase inhibitors (BTKi) are highly efficacious oral agents FDA-approved for treatment of specific B-...
Upfront comprehensive donor search overcomes the impact of poor search prognosis, irrespective of racial background
Abstract Introduction: Access to suitably matched donors remains a major barrier to allogeneic hematopoietic cell transplantation (HCT), par...
DNA methylation episignature as a novel diagnostic tool for diamond-blackfan anemia
Abstract Background Diamond-Blackfan anemia syndrome (DBAS) is a rare inherited bone marrow failure syndrome (IBMFS) characterized by impair...