Blood
Articles in this Issue
Integrated machine learning analysis for automatic recognition of b-ALL MRD level in flow cytometry list mode data
Abstract Introduction Minimal residual disease (MRD) detection by flow cytometry is a powerful prognostic indicator in B...
Voriconazole (VCZ) therapeutic drug monitoring (TDM) for prophylaxis and treatment of invasive fungal diseases in hematology patients – daily clinical practice and evidence from clinical trials
Abstract Invasive fungal diseases (IFD) are a life-threatening complication during treatment of hematological malignancies. VCZ is approved...
A novel in-frame calreticulin mutation induces activation of JAK-STAT signaling and thrombocytosis
Abstract Mutations in the gene encoding calreticulin (CALR) represent the second most common genetic abnormality in BCR:ABL negative myelopr...
Hypoxia-driven complement activation expands circulating endothelial cells in transplant-associated thrombotic microangiopathy: A multi-omics single-cell and functional study
Abstract Background Transplant-associated thrombotic microangiopathy (TA-TMA) lacks validated biomarkers and targeted therapies. We hypothes...
Crenolanib plus salvage chemotherapy improves outcomes in FLT3-mutant and NPM1 co-mutated relapsed/ refractory (R/R) Acute Myeloid Leukemia (AML): Results from a randomized, placebo-controlled, double-blind trial
Abstract Background:Crenolanib is a potent type 1 FLT3 inhibitor with activity both as a single agent and in combination with chemotherapy i...
Vmx-C001 has no effect on the anticoagulant function of heparin in healthy subjects
Abstract Introduction: VMX-C001 is in clinical development to restore coagulation in patients taking factor Xa direct oral anticoagulants (F...
Next-generation sequencing for myeloid malignancies: Uncovering clinical gaps in physician knowledge and practice
Abstract Background Next-generation sequencing (NGS) is integral to the diagnosis, risk stratification, and treatment selection for patients...
Longitudinal immune dynamics associated with chronic lymphocytic leukemia development in mice with 13q14 deletion and modulation by early BTK inhibition
Abstract Background The deletion of 13q14 (del(13q14)) is the most common genetic alteration in Chronic Lymphocytic Leukemia (CLL), found in...
Identification of TPR::FGFR1 fusion in an unusual case of concurrent acute B lymphoblastic leukemia and T-lymphoblastic lymphoma: Case report and review of literature
Abstract Myeloid/lymphoid neoplasms with FGFR1 rearrangement (MLNAF) are rare, with only approximately 100 cases reported worldwide.1 A wide...
Integrated multi-omics study identifies ursolic acid as a novel therapeutic agent targeting the TNF-α/TAK1/IKKβ/NF-κB axis in hepatic sinusoidal obstruction syndrome
Abstract Background Hepatic sinusoidal obstruction syndrome (SOS) is a lethal complication of hematopoietic stem cell transplantation (HSCT)...
High rates of severe maternal morbidity and preterm birth among pregnant individuals with sickle cell disease, a nationwide study from 2020-2024
Abstract Introduction: Previous data demonstrate that pregnant individuals with sickle cell disease (SCD) face significantly elevated risks...
Therapeutic resistance in aggressive B-cell lymphoma is overcome through the reciprocal enhanced efficacy by CDK9 inhibitors and CAR-T cells
Abstract Although both CDK9 inhibitors and chimeric antigen receptor (CAR)-T cells have shown significant clinical promise in treating B-cel...
Current clinical concerns for patients with hereditary hemochromatosis – a Delphi consensus study
Abstract Introduction Hereditary hemochromatosis (HH) is caused by hepcidin dysregulation and is characterized by excessive iron accumulatio...
Patient journey with axicabtagene ciloleucel for relapsed or refractory large B cell lymphoma in Canada: Manufacturing experience and impact of patient location to treatment centre
Abstract Introduction: Axicabtagene ciloleucel (axi-cel) is an autologous anti-CD19 chimeric antigen receptor (CAR) T cell therapy approved...
Outcomes of CD20xCD3 bispecific antibody therapy as holding or bridging therapy prior to chimeric antigen receptor T-cell infusion in aggressive B-cell lymphomas
Abstract Introduction CD19-directed chimeric antigen receptor T-cell (CAR-T) therapy is approved as second-line treatment for aggressive B-c...
Characteristics, survival, and causes of death in patients with APL from Chile
Abstract Background: Acute promyelocytic leukemia (APL) is prevalent in Latin America and carries a high risk of early-onset complications....
Therapeutic effect of menin inhibitors is reversible in AML treatment and could be enhanced by the targeting of differentiation associated chromatin complex
Abstract Menin, encoded by the MEN1 gene, is a chromatin adaptor critical in AML through its role in the MLL complex. Inhibiting the Menin–M...
Detection of minute FLT3-ITD clones at day +30 post-allo-HSCT predicts high relapse risk and informs maintenance therapy in AML: A niche cohort study
Abstract Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has improved the prognosis of patients with acute myeloid leukemia (...
Digital preservation following purpura fulminans: A case report
Abstract Background Disseminated intravascular coagulation (DIC) is a complex, life-threatening disorder characterized by systemic activatio...
EZH2 molecular alterations drive micromegakaryocyte expansion in MDS defining a specific high-risk group
Abstract BackgroundMyelodysplastic neoplasm/syndrome (MDS) subtypes are categorized by genetic aberrations leading to specific morphological...
ALL-pharmacotyping data portal: An open-source platform for exploring genomics of leukemia drug susceptibility and resistance
Abstract Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, characterized by a multitude of molecular subtypes with vas...
NADPH controls a cell state vulnerability towards ferroptosis in acute lymphoblastic leukaemia
Abstract Background and significance: Ferroptosis is a distinct form of non-apoptotic cell death characterised by iron-dependent lipid perox...
Long-term treatment duration and safety of axatilimab among patients with chronic graft-versus-host disease in AGAVE-201
Abstract Introduction: Chronic graft-versus-host disease (cGVHD) is a major cause of morbidity and non-relapse mortality among patients who...
Incidence and risk factors for new overweight or obesity following hematopoietic cell transplantation for sickle cell disease
Abstract Longterm outcomes after curative allogeneic hematopoietic cell transplantation (HCT) for sickle cell disease (SCD) are being establ...
Phenotypic landscape and clinical outcomes associated with promotor TERT mutations in patients with telomere biology disorders
Abstract Introduction: TERT promoter (pTERT) variants are among the most frequent genetic alterations in human cancers, where they drive onc...