Proceedings of the National Academy of Sciences
Articles in this Issue
Genomics and genetic rescue
Payoff equivalence and complete strategy spaces of direct reciprocity
Repeated games and stochastic games are important frameworks to study direct reciprocity. Individuals react strategically to their coplayers’ previous behavior. While strategies in such games can be a...
Shaking and pushing skyrmions: Formation of a nonequilibrium phase with zero critical current
In three-dimensional chiral magnets, skyrmions are line-like objects oriented parallel to the applied magnetic field. The efficient coupling of magnetic skyrmion lattices to spin currents and magnetic...
The dynamics of cooperation in asymmetric public goods games
When people collaborate in groups, they routinely face collective action problems: for the group effort to succeed, individuals need to cooperate despite any incentives to defect. These problems can b...
Automated decision-making by chemical echolocation in active droplets
Motile microorganisms, like bacteria and algae, unify abilities like self-propulsion, autonomous navigation, and decision-making on the micron scale. While recent breakthroughs have led to the creatio...
Active learning design of bcc solid solution alloys with gigapascal strength and elemental metal–level ductility
Body-centered cubic (bcc) alloys can achieve gigapascal-level yield strengths but typically are limited in tensile ductility (<20%), contrasting sharply with elemental metals (the largest elongatio...
Functional motifs in food webs and networks
When studying a complex system, it is often useful to think of the system as a network of interacting units. One can then ask if some properties of the entire network are already explained by a small...
Tantalum alloy–based resonators for quantum information systems
Utilizing tantalum (Ta) in superconducting circuits has led to significant improvements, such as high qubit lifetime (T 1 ) and quality factors in both qubits a...
Representational drift reflects ongoing balancing of stochastic changes by Hebbian learning
Recent evidence indicates that even under stable environmental and behavioral conditions, responses to sensory stimuli undergo continuous reformatting over the course of days, a condition described as...
Correction for Hou et al., Therapeutic restoration of mitochondria–endoplasmic reticulum cross talk for osteoarthritis
Evolution of sensory systems underlies the emergence of predatory feeding behaviors in nematodes
Understanding how animal behavior evolves remains a major challenge, with few studies linking genetic changes to differences in neural function and behavior across species. Here, we identify specific...
Germline fate determination by a single ARGONAUTE protein in <i>Ectocarpus</i>
ARGONAUTE (AGO) proteins are a highly conserved family of RNA-binding proteins that play central roles in gene regulation and developmental processes across eukaryotes. Although AGO family members hav...
The kinetochore corona orchestrates chromosome congression through transient microtubule interactions
For proper segregation of chromosomes and successful cytokinesis, chromosomes must first “congress”—gather in a tight plate near the spindle equator. Molecular mechanism(s) of congression are not full...
In situ NMR and integrative proteomics reveal the interaction signature of serum α-synuclein
Alpha-synuclein (αS) plays a central role in several neurodegenerative diseases. Although predominantly neuronal, αS is also present in peripheral fluids such as serum and cerebrospinal fluid (CSF), w...
Drospondin, a glial glycoprotein with similarities to human Reelin/F-spondin, contributes to <i>Drosophila</i> brain development and function
Reelin is a secreted glycoprotein with roles in the development of the mammalian neocortex, hippocampus, and cerebellum. This vertebrate signaling molecule also contributes to adult brain function. Ma...
Optical voltammetry of redox processes inside a nanohole with opto-iontronic microscopy
Cyclic Voltammetry (CV) is the most commonly used method in electrochemistry to characterize electrochemical reactions, usually involving macroscopic electrodes. Here, we demonstrate an optical CV tec...
Integrated phenotypic screening and chemical proteomics identifies ETF1 ligands that modulate viral translation and replication
Emerging and reemerging viruses pose a significant threat to global health. Although direct-acting antivirals have shown success, their efficacy is limited by the rapid emergence of drug-resistant vir...
Elucidating chiral myosin–induced actin dynamics: From single-filament behavior to collective structures
The myosin superfamily encompasses over 70 classes, each with multiple subclasses, and exhibits substantial diversity in properties such as velocity, ATPase activity, duty ratio, and directionality. T...
FcγRIIB functions as an IgG transporter in the mammary gland
In mammals, passive acquisition of maternal immunoglobulins is essential for neonatal immune development and defense against infections. IgG, a central mediator of humoral immunity, is maternally tran...
Mapping targetable sites on the human surfaceome for the design of novel binders
The human cell surfaceome, integral to cell communication and disease mechanisms, presents a prime target for therapeutic intervention. De novo protein binder design against these cell surface protein...
Medullary and C3–C4 propriospinal pathways underlying mammalian forelimb movement control
Classic models associate goal-directed upper limb movements with cortical motor areas and balance control with the brainstem. However, recent rodent studies suggest that medullary regions and local sp...
The seeds of the future are in the present: A blind exploration of metastable states
In this work, we present a type of molecular dynamics simulation that aims at finding, in a blind way, metastable states. Using only data coming from an initial unbiased simulation, and with the help...
OsKAT1 is a short Shaker potassium channel involved in root-to-shoot potassium translocation and contributes to rice grain yield
Shaker potassium channels play essential roles in K + uptake and distribution in plants. Studies on Shaker channels in Arabidopsis...
A neuron–astrocyte signaling axis in the ACC sustains diabetic neuropathic pain
RHOA controls oncogenic B cell receptor signaling in aggressive lymphoma
Diffuse large B cell lymphoma (DLBCL) is characterized by a variety of specific genetic alterations that impact signaling pathway dependencies and therapeutic outcomes. Among the recurrently mutated g...