Proceedings of the National Academy of Sciences

Allosteric coupling between PIP ₂ and Ca ²⁺ binding sites gates TMEM16A channels

TMEM16A channels conduct Ca 2+ -activated Cl − currents that underlie essential physiological processes including epithe...

Religious markers reduce perceived trustworthiness in a Muslim-majority country

First impressions often hinge on visible cues, leading people to infer the trustworthiness of strangers from their appearance and dress. While religiosity is generally associated with greater perceive...

Dual quantum locking: Dynamic coupling of H ₂ and H ₂ O sublattices in hydrogen-filled ice

Hydrogen hydrates (HH) are a unique class of materials composed of hydrogen molecules confined within crystalline water frameworks. Among their multiple phases, the filled ice structures, particularly...

High-speed in situ tomographic imaging at lab scale

Bimodal dynamics of viscous pearls

Droplets on super-repellent materials adopt the shape of pearls, which makes them highly mobile, owing to the conjunction of low contact line pinning with small dynamical friction. This property is es...

Methionine-specific nonreversible bioconjugation: Advancing precision protein modification

We present a methionine-selective, nonreversible bioconjugation strategy that employs activated allylic bromides under mild, aqueous reaction conditions compatible with various peptides and proteins....

The psychological ability to adopt recommended coping responses reduced infections during the COVID-19 pandemic

During the COVID-19 pandemic, a key question for researchers and authorities was to understand the psychological motivations that sustained public engagement in protective behavior such as physical di...

Phylogenomic synteny reveals paleohexaploid-derived genomic blocks across Asteraceae

The Asteraceae (Compositae) is the largest flowering plant family, ubiquitous in most terrestrial communities, and morphologically diverse. A two-step, ancient whole genome triplication (paleohexaploi...

Decoding antibody response to MERS-CoV in wild dromedary camels

Wild dromedary camels in the Arabian Peninsula and Africa have harbored antibodies against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) for decades, predating zoonotic spillover to humans....

Climate change drives a decline in global grazing systems

Grazing systems represent the most extensive production systems in the world and are highly sensitive to climate change. However, their global-scale sensitivity and vulnerability to climate impacts re...

Short-range electrostatic screening in ionic liquids as inferred by direct force measurements

Previous experimental reports of long-range interactions in ionic liquids (ILs) stand in contradiction with theoretical predictions and numerical simulations. To provide insights into the literature d...

Metabolic stress conditions dictate MAPKAPK2-dependent efficiency of MEK1/2 inhibition in colorectal carcinoma

The kinase MAPKAPK2 regulates cell survival, proliferation, and death, and is upregulated in colorectal carcinoma (CRC) where it is associated with tumor growth and progression. However, how it regula...

Listening to the quiescence of single STIM1 dimers

Beta arrestin 1 is a key regulator of pulmonary vascular tone

Pulmonary arterial hypertension (PAH) is a serious disorder, in which increased vascular tone is one of the critical hallmarks. Since beta arrestins (bArrs) have been shown to regulate smooth muscle t...

Global nutritional equity of fishmeal and aquaculture trade flows

Aquaculture, the single fastest growing food sector, is central to achieving key Sustainable Development Goals (e.g., SDG 2: Zero Hunger). Linking the nutrient composition of >2,800 aquatic species...

Engineering chimeric antigen receptor CD4 T cells for Alzheimer’s disease

Alzheimer’s disease (AD) is the prevailing cause of age-associated dementia worldwide. Current standard of care relies on antibody-based immunotherapy. However, antibody-based approaches carry risks f...

Social information creates self-fulfilling prophecies in judgments of pain, vicarious pain, and cognitive effort

Expectations can shape perception and potentially lead to self-fulfilling prophecies such as placebo effects that persist or grow over time. Nonetheless, whether and how unreinforced and unconditioned...

Photoenzymatic Csp ³ –Csp ³ bond formation via enzyme-templated radical–radical coupling

Cross-couplings are essential reactions in modern chemical synthesis, enabling the rapid construction of complex molecules from simple precursors. Transition metal catalysts are prized for these trans...

Global stratospheric methane loss from satellite observations

Stratospheric CH 4 oxidation represents both an important sink in the global CH 4 budget and a major source of stratosph...

Structural and mechanistic diversity of glycogen phosphorylases from gut bacteria

Glycogen phosphorylase (GP) plays a central role in glycogen metabolism. While the structure and regulation of mammalian GPs have been extensively studied, the corresponding mechanisms in gut bacteria...

Sound reasons for tympanic hearing in mammalian precursors

Parasitic castration by a viral protein tyrosine phosphatase targeting the host cell cycle checkpoint protein Rad9A

Parasitic castration is a widespread strategy where parasites hijack host reproductive resources, yet the key molecular mechanisms driving this phenomenon remain poorly understood. Here, we reported t...

Coviretinopathy: COVID-19-induced VEGF-dependent retinopathy

COVID-19 has been associated with high prevalences of retinal diseases in humans. However, cellular and molecular mechanisms that underlie the COVID-19-associated retinopathy remains unknown. Here, we...

A c-Cbl/Cbl-b antagonist inhibits EGFR ubiquitylation and sustains EGFR phosphorylation to enhance corneal re-epithelialization

Growth factor receptor signaling is a critical component of tissue growth, homeostasis, and wound healing. However, receptor desensitization limits the use of exogenous growth factors as a restorative...

Antagonism of RNA silencing in the yellow fever mosquito, <i>Aedes aegypti</i> , by the nsP2 protein of the prototype alphavirus

Alphaviruses establish persistent infections in mosquito vectors despite robust antiviral RNA interference (RNAi) pathways, suggesting that they employ mechanisms to counteract host immunity. We demon...