Proceedings of the National Academy of Sciences
Articles in this Issue
Abdominal ultrasound activates afferent vagus nerve fibers and induces anti-inflammatory effects
Abdominal ultrasound has emerged as a noninvasive modality with immunomodulatory potential. Although its anti-inflammatory effects have been demonstrated in various disease models, the underlying mech...
Bacterial iron acquisition by <i>Escherichia coli</i> is facilitated by amino acid complexation in a rapid-renewal environment
In natural environments, bacteria often encounter low concentrations of nutrient mixtures that are continuously replenished by physical processes such as fluid flow. Studying bacterial physiology unde...
Natalizumab exacerbates astrocytopathy in NMOSD via blockade of endothelial VCAM1–astrocytic integrin α4 interaction
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune inflammatory disorder of the central nervous system (CNS) that shares clinical features with multiple sclerosis (MS) but typically m...
Commodity frontiers expand more slowly into tropical forests where forest smallholders are present
The expansion of commodity agriculture into tropical forests leads to major social–ecological impacts. Yet little is known about where and how the capitalized actors driving this expansion interact wi...
Correction for Regattieri et al., A speleothem record from the Fertile Crescent covering the last deglaciation better contextualizes neolithization
Dual inhibition of mTOR and calcineurin pathways mitigates missing self–induced NK cell–mediated microvascular rejection
The inability of graft endothelial cells to deliver HLA-I-dependent inhibitory signals to recipient natural killer (NK) cells (missing self, MS), drives donor-specific antibody-independent microvascul...
Ion transport control in electrolytes via electrochemical doping
Doping to control carrier (electron or hole) transport is foundational to modulate the properties of semiconductors, enabling the development of homojunctions and heterojunctions for integrated electr...
Lipid nanoparticle GM-CSF replacement for autoimmune pulmonary alveolar proteinosis
Granulocyte–macrophage colony-stimulating factor (GM-CSF) deficiency drives autoimmune pulmonary alveolar proteinosis (aPAP), a disease characterized by impaired macrophage-mediated clearance of pulmo...
A ribosomally synthesized and posttranslationally modified peptide with ADP-ribosylation
Ribosomally synthesized and posttranslationally modified peptides (RiPPs) are a fertile ground for uncovering new enzymatic chemistry and structural complexity. Here, we describe minviopeptin, an unus...
Electrotunable coupling between an epsilon-near-zero thin film and conducting polymer nanoantennas
Plasmonic resonances in nanostructured conducting polymers provide a compelling route to actively tunable nanophotonics and metasurfaces, owing to their ability to be dynamically modulated through ele...
Optogenetic control of transition to metamorphosis
System identification approaches are commonly used in engineering to infer simple yet predictive models of complex systems from their responses to time-dependent perturbations. Here, we apply this str...
What is the general Welfare: Welfare economic perspectives on equity
Researchers cannot definitely interpret what the framers of the United States Constitution intended when they wrote of the “general Welfare.” Nevertheless, researchers can conjecture by specifying soc...
Intravenous infusion of engineered megakaryocytes to produce oncolytic platelets in vivo for enhanced cancer immunotherapy
Tumor-targeted delivery of oncolytic viruses (OVs) via systemic administration could not only expand virotherapy beyond primary tumors to widespread metastases, but also improve clinical adherence and...
Leaderless RiPPs expand the repertoire of fungal secondary metabolites
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are secondary metabolites produced by bacteria, plants, animals, and fungi. Canonical fungal RiPP precursors possess a leader...
Synaptic transmission: Munc13 assembles onto PI(4,5)P <sub>2</sub> -rich domains into trimers that cooperate to capture vesicles
Munc13-1 is a key protein involved in priming synaptic vesicles for rapid release at the presynaptic plasma membrane. It was previously revealed that Munc13-1 cycles between at least two alternate con...
More social interactions, more polarization? The evidence is not there
Learning nature’s assembly language with polymers
The self-assembly of matter into ordered structures is ubiquitous throughout nature and engineered systems. Programming a material’s macroscopic properties via molecular-level structural control is a...
A systems approach identifies MERTK as a therapeutic vulnerability in ZFTA-RELA-driven ependymomas
Ependymomas (EPN) are rare central nervous system tumors that account for approximately 10% of intracranial tumors in children and 4% in adults. Despite their clinical and molecular heterogeneity, spa...
Reply to Völker et al.: On the evidence of increased close friendships in societies
Spatiotemporal histogenesis of the developing human cerebellum reveals dynamic layering of Bergmann glia
Bergmann glia (BG) are a specialized glial population essential for cerebellar development, yet their developmental timeline and molecular identity in the human cerebellum remain poorly understood. He...
Magnetic field–enhanced alkaline water electrolysis from laboratory to industry
The fundamental limitation of water oxidation in alkaline water electrolysis (AWE) lies in the progressive depletion of dynamic active sites and rapid dissipation of local active ion concentration, a...
BacA(SbmA) importer of legume symbiotic NCR peptides: Protein architecture, function, and evolutionary implications
Some legumes encode families of NCR (Nodule-Cysteine-Rich) peptides that cause their rhizobial partners to terminally differentiate during the development of a nitrogen-fixing symbiosis....
Whole-body central processing of lateral line inputs encodes flow direction relative to the center-of-mass
From shifting visual scenes to tactile deformations and fluid motion, animals interpret patterns of sensory flow around their body to construct internal models and produce adaptive behavior. Understan...
A photosynthetic–respiratory electron transport chain chimera based on photosystem I and cytochrome <i>c</i> oxidase on graphene oxide
The self-assembly of enzyme proteins on 2D nanomaterials has enabled the construction and functional control of viable biochemical pathways. However, enzymatic cascades, which combine essential compon...
Human mitotic spindles as active liquid crystals: From collective behaviors to discrete filaments
How thousands of microtubules (MTs) and molecular motors self-organize into spindles remains poorly understood. By combining static, nanometer-resolution, large-scale electron tomography reconstructio...