Proceedings of the National Academy of Sciences
Articles in this Issue
Lower charge, higher order: Revising electrostatic control of nematic phases in 2D polyelectrolytes
Classical theories of nematic ordering in charged platelets predict that increasing surface charge stabilizes alignment. They also predict enhanced alignment when ionic strength is reduced. Here, in a...
Divergent dietary and defensive adaptations of closely related coexisting seed bugs
Ecologists use multiple approaches to decipher factors mediating the origin and maintenance of biodiversity. Using closely related species, we retrospectively investigated divergence in diet and defen...
The effect of land costs on the economic and sustainability performance of solar photovoltaics in China
Scaling up solar photovoltaics (PV) is essential for global decarbonization, particularly in China—the world’s largest greenhouse gas (GHG) emitter. Despite leading in PV installations, China has yet...
Spatially resolved denitrification coupled with methane and arsenite oxidation at the millimeter-scale straw–soil interface
Straw return reshapes the biogeochemical processes in paddy soils by driving microbial transformation of key elements. Despite growing awareness of these individual processes, the integration of these...
Extracellular stiffness regulates cell fate determination and drives the emergence of evolutionary novelty in the teleost heart
The diversification of life is driven by the acquisition of new phenotypic traits, known as evolutionary novelties. While some genetic mechanisms underlying such traits have been identified, the role...
Genomes of the Golden Horde elites and their implications for the rulers of the Mongol Empire
The Golden Horde, the northwestern extension of the Mongol Empire ruled by Genghis Khan’s descendants, holds a pivotal place in the history of Central Eurasia and Eastern Europe. Consequently, underst...
Lipid nanoparticle–mediated in vivo generation of panCAR immune cells for solid tumor immunotherapy
Adoptive cell therapies that genetically engineer immune cells with chimeric antigen receptors (CARs) have shown limited success against solid tumors due to the immunosuppressive tumor microenvironmen...
Correction for Lee et al., Saccade-related LFP power transients in the primate amygdala and hippocampus linked to the perception of social status
Lamin B receptor upregulation in metastatic melanoma causes nuclear envelope fragility in confined migration during cancer invasion
Cancer cells migrate through regions of tissue confinement during metastasis, causing nuclear envelope (NE) rupture, which generates heritable DNA damage and disease aggression. We sought to determine...
β <sub>2</sub> -microglobulin inhibits <i> <i>Escherichia coli</i> </i> biofilm formation via selectively blocking curli assembly
Bacteria have evolved a remarkable strategy to thrive in hostile environments by creating well-organized microcommunities known as biofilms. Biofilms pose a serious global health challenge due to thei...
Aging of amorphous materials under cyclic strain
Amorphous materials driven away from equilibrium display a diverse repertoire of complex, history-dependent behaviors. One striking feature is a failure to return to equilibrium after an abrupt change...
Democratizing space: India’s frugal space innovation provides key lessons for emerging nations
Reply to Fitzgerald et al.: Mischaracterizing our findings; the cognitive profile of elite footballers remains robust
CDKL5 modulates the plasticity of excitatory synapses via liquid–liquid phase separation
Activity-dependent synaptic remodeling, essential for neural circuit plasticity, is orchestrated by central organizers within the postsynaptic density (PSD), including the scaffolding protein PSD95. H...
Oncogenic function and transcriptional dynamics of MYCN in liver tumorigenesis
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. It is often diagnosed at advanced stages and characterized by high recurrence rates. Although chronic liver inflammation...
Cryo-EM structure of locked spike glycoprotein from bat SARS-like coronavirus WIV1, molecular dynamics and biophysics across host range
As made evident by severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and SARS-CoV-2 pandemics, the possibility of a SARS-like coronavirus (SL-CoV) emerging again in humankind after zoonotic...
A host-derived volatile primes context-dependent foraging behavior in parasitic nematodes via a lysosome-associated neural pathway
Entomopathogenic nematodes (EPNs) are valued for sustainable pest control, yet their efficacy hinges on matching foraging behavior to host ecology. The nematode Steinernema carpoca...
Enhanced screening via a pure DNA-encoded peptide library enabled by an Fmoc modification
Peptide-based molecules have widespread therapeutic applications due to their potent binding affinity and relative metabolic safety. Peptide therapeutics are developed using library screening that sam...
Unraveling hidden symmetry breaking in racemic compounds
Racemic compounds, consisting of an equimolar mixture of enantiomers in crystalline form, are conventionally regarded as fully symmetric and are often dismissed as a trivial phenomenon due to their ab...
Negative social ties as emerging risk factors for accelerated aging, inflammation, and multimorbidity
Negative social ties, or “hasslers,” are pervasive yet understudied components of social networks that may accelerate biological aging and morbidity. Using ego-centric network data and DNA methylation...
Cooperative environments bolster feelings of autonomy in dyads, teams, and organizations
Autonomy promotes important psychological outcomes. Although cooperation and competition are the building blocks of social interactions, little is known about how they shape feelings of autonomy in dy...
Will online behavioral research follow the fate of online survey research?
Reply to Van der Stigchel et al.: Empirical evidence that AI survey contamination is real and substantial
The human insula encodes somatotopic representation of motor execution with an effector-specific connectome map to primary motor cortex
Understanding motor representation in the human brain requires mapping beyond the primary motor cortex, into the distributed networks that coordinate complex movements. The insular cortex, a multifunc...
The ISR downstream effector ATF4 promotes mGluR-dependent long-term depression and associated behavior
The integrated stress response (ISR) plays a crucial role in cognition via bidirectional modulation of the two major forms of synaptic plasticity, long-term potentiation, and long-term depression (LTD...