Proceedings of the National Academy of Sciences
Articles in this Issue
Revisiting the cognitive advantages of professional soccer players
Correction for Waldeck-Weiermair et al., Dynamic regulation of receptor-modulated endothelial NADPH oxidases
T-cadherin, a major adiponectin binding partner, suppresses ERK signaling in metabolic tissues
T-cadherin, which is a major adiponectin binding partner, exerts various organ-protective effects. However, the specific changes in intracellular signaling that are induced by T-cadherin in metabolic...
Key role of moss in supplementing nitrogen for plant growth under warming in a permafrost ecosystem
Enhanced plant productivity under climate warming may partially offset soil carbon losses in cold ecosystems, but this compensation depends on whether soil nitrogen (N) supply can keep pace with the i...
Place cells in CA1 lack topographical organization of firing locations
Topography is a well-described and well-known concept for cortical organization in primary sensory and motor cortices of mammalian brains. Similar isomorphic mapping of the environment is absent in mo...
<i>Grin2b</i> 3’UTR is necessary for synaptic plasticity and spatial learning
Spatially precise protein synthesis is critical for synaptic plasticity and cognitive function. The GRIN2B transcript encodes the GluN2B subunit of N-methyl-D-a...
Cryogenic electron tomography by the numbers: Charting underexplored lineages in structural cell biology
Imaging cells and their interactions across the whole biosphere with molecular-scale resolution is key for understanding structure–function relations. Cryogenic electron tomography (cryo-ET) is a powe...
Seeing the forest through the trees: Harmonizing infection-associated chronic illnesses research
Accurate conformational ensembles of intrinsically disordered proteins using reweighting based on NMR chemical shifts
Intrinsically disordered proteins and protein regions (IDRs) underpin a wide range of vital biological processes but exhibit dynamic and heterogeneous conformations. Currently, many computational effo...
Redefining koinophilia: Solution to social isolation and polarization
Neuropixels reveal laminar microcircuit organization in monkey V1 in vivo
The relationship between different cell populations in monkey primary visual cortex and their role in visual function is not fully resolved. We combined high-density Neuropixels recordings across laye...
Profile of Qiang Fu
Atmospheric scientist Qiang Fu uses satellite observations, numerical simulations, and theoretical analysis to investigate how changes across different layers of the atmosphere—and their circulation—a...
Network-based genetic monitoring of landscape fragmentation
Habitat fragmentation is one of the most immediate and substantial threats to biodiversity, generating isolated populations with reduced genetic diversity. Genetic monitoring has become essential for...
A multiscale theory framework predicts size- and ordering-dependent activity in Pt–Cu oxygen reduction reaction catalysts
Optimizing the oxygen reduction reaction (ORR) performance of Pt-based alloy nanocatalysts requires a quantitative understanding of how catalytic activity and durability depend on nanoparticle composi...
Correction for Impheng et al., Peptide-based covalent inhibitor of tubulin detyrosination promotes mesenchymal-to-epithelial transition in lung cancer cells
Monitoring of plasma and urine tumor-derived DNA to inform bladder-sparing approaches for patients with muscle-invasive bladder cancer
We previously reported initial results from a clinical trial testing a strategy in which patients with muscle-invasive bladder cancer (MIBC) achieving a clinical complete response after cystoscopic re...
Distinct impact of PI(4)P flux on PI(4,5)P <sub>2</sub> steady states and oscillations
Plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate [PI(4,5)P 2 ] regulates indispensable processes such as exocytosis, endocytosis, and actin cytoskelet...
A lateralized sensory signaling pathway mediates context-dependent olfactory plasticity in <i>Caenorhabditis elegans</i>
Lateralization of neuronal functions plays a critical role in regulating behavioral flexibility, but the underlying molecular mechanisms are challenging to establish at a single-neuron level. We previ...
Connected network model for the mechanical loss of amorphous materials
Dissipation in amorphous solids at low frequencies is commonly attributed to activated transitions of isolated two-level systems (TLS) that come in resonance with elastic or electric fields. Materials...
Aubry–André localization transition for an active undulator
The transport of deformable self-propelling objects like bacteria, worms, snakes, and robots through heterogeneous environments is poorly understood. Here we use experiment, simulation, and theory to...
Artificially constructed collagen-targeting receptors on mesenchymal stromal cells promote anoikis resistance and tissue repair
Mesenchymal stem cell (MSC)-based therapy holds significant promise in regenerative medicine, leveraging their multipotent differentiation capacity and paracrine effects. However, clinical translation...
Lipid landscaping of the bacterial cell surface
More than a blueprint: Developmental regulators secure the cellular environment for regeneration
Experimental warming decouples plant–fungal symbiont interactions and leads to a more conservative ecosystem
Climate forecasts project rising temperatures for every land surface on Earth. Predicting the consequences of climate warming poses a challenge for science and society. Shifts in plant–microbial inter...
Foliar dewdroplet–induced redox cascades promote early flowering in <i>Brassicaceae</i> plants
Atmospheric water inputs such as dew are often overlooked in plant biology. We show that foliar dewdrops act as biochemical microreactors that trigger flowering in Arabidopsis thal...