Proceedings of the National Academy of Sciences
Articles in this Issue
Humanized extracellular vesicles for efficient RNA delivery
Engineered extracellular vesicles (EVs) are a class of nonviral delivery vectors for RNA-based vaccines and gene therapies. A specialized form of engineered EVs, known as enveloped protein nanocages (...
Typical development of the human fetal subplate: Regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI
The subplate (SP) is a transient fetal brain compartment supporting neuronal migration, axonal ingrowth, and early cortical activity, yet the dynamics of its regional development remain poorly underst...
Deep learning–enabled scaffolding of spatial arrays of PfCSP epitopes
Malaria is a leading cause of disease in developing countries. The licensed malaria vaccine RTS,S/AS01 confers partial protection in part due to the elicitation of circumsporozoite protein (CSP) antib...
The colors of images preferred by individual voxels can be used to delineate functionally distinct visually responsive brain areas
We exploited co-occurrences between color and other properties of natural scenes to identify and visualize functionally distinct brain regions. For each voxel in the Natural Scenes Dataset (NSD), we c...
Meiotic prophase I disruption as a strategy for nonhormonal male contraception using small-molecule inhibitor JQ1
Developing safe, reversible, and nonhormonal male contraceptives has been hindered by the lack of defined biological windows that can be transiently interrupted without compromising long-term fertilit...
Munc13 serves as a molecular filter for SNARE sorting and assembly in active zone condensates
Neurotransmitter release requires the precise localization and assembly of the SNARE machinery at presynaptic release sites. Although liquid–liquid phase separation of active zone scaffolds is known t...
A regulatory axis for tonotopic MYO7A expression in cochlear hair cells
Myo7a , a gene mutated in Usher syndrome and nonsyndromic deafness, encodes an unconventional myosin essential for hair cell function. Our previous work revealed that cochlear hair...
Antagonism by the type VI secretion system of <i>Bacteroides fragilis</i> is controlled by a TetR family regulator and released small molecule
Antagonistic systems of bacteria are often tightly regulated. The human gut Bacteroidales harbor three distinct antagonistic type VI secretion systems (T6SS), one of which is present only in...
Spatial and semantic memory reorganize a hippocampal long-axis gradient
The hippocampus supports episodic memory by binding spatial and semantic information, yet how this information is simultaneously organized along its long axis remains debated. Gradient accounts propos...
Shift current anomalous photovoltaics in a double perovskite ferroelectric
Ferroelectric anomalous photovoltaic (APV) effect, as a fascinating physical conceptual phenomenon, holds significant potentials for new optoelectronic device applications. However, due to the lack of...
Heat- and PIP2-dependent TRPM4 activity underlies mutually exclusive human diseases
Temperature-sensitive transient receptor potential melastatin subfamily 4 (TRPM4) ion channels convert intracellular calcium increases into membrane depolarization, thereby linking these two powerful...
Proton-activated chloride channel 1 is essential for innate host defense against bacterial sepsis
Bacterial sepsis remains a devastating clinical problem. Here, we describe a protective role for the recently discovered acid-sensitive, proton-activated chloride channel, PACC1 (PAC/ASOR/TMEM206), du...
Cosmic ray–driven electron-induced reaction theory does not quantify spatiotemporal variations in lower-stratospheric ozone and temperature
The influence of electrical charge on plasmodesma conductivity
Most plant tissues are symplasms in which cells are connected by plasmodesmata, membrane-lined cytosplasmic bridges that enable diffusive and/or advective cell-to-cell movements of components of the c...
Reply to Mazzaferro et al. and Niebaum: The limits of alignment: Grounding executive functions without assuming special contexts
Phage display–mediated immuno-PCR to detect low-abundance secreted proteins in <i>Drosophila</i>
Circulating hormones, that mediate communications across organs to maintain physiological balance, are commonly detected and quantified using enzyme-linked immunosorbent assays (ELISAs). However, whil...
Reconsideration of Secure Communities rollout reveals preemptive local-federal cooperation in immigration enforcement
Qualitative studies on local police collaborations with federal immigration enforcement authorities reveal risks to the well-being of noncitizens, particularly the undocumented, and their families and...
Extracellular matrix chemistry tunes bacterial biofilm metabolism and optimizes fitness
Chemically complex extracellular matrices define cellular microenvironments and shape cell behavior across all domains of life. But how has evolution optimized these materials to ensure the success of...
Timing the decline: Cellular circadian rhythms and Alzheimer’s disease
Structural innovation and flexibility in plant chemical defenses
A rare glycoalkaloid biosynthetic pathway from wild potato unlocks genetic routes to Colorado potato beetle resistance
Plants in the family Solanaceae produce steroidal glycoalkaloids (SGAs), specialized metabolites that are toxic to consumers while providing protection against...
AI-derived therapeutic development of a serotonin receptor–targeting drug for the treatment of opioid use disorder
The opioid epidemic has led to a devastating loss of life nationwide. Of those dependent on opioids, many individuals desire to quit or reduce use, but their efforts are often unsuccessful given the p...
Configuration of circum-Antarctic circulation at the last green- to icehouse climate transition
During the Eocene–Oligocene Transition ( ∼ 34.4 to 33.7 Ma), major c...
A swarm intelligence approach to density function reconstruction from moments using entropy optimization
This paper presents a bioinspired optimization approach to address a class of inverse problems involving entropy optimization (EOP) from knowledge of the moments of a distribution function. In particu...