Proceedings of the National Academy of Sciences
Articles in this Issue
Semiochemicals and odorant receptors underlying potato cultivar susceptibility and resistance to potato tuber moth
Infestation of potato by the potato tuber moth ( Phthorimaea operculella ) varies markedly among cultivars, yet the chemical and molecular mechanisms underlying...
Expanded applicability of the triple oxygen isotope composition of phytoliths as an indicator of atmospheric relative humidity
The central dogma in reverse
Proteome-wide prediction of interactions between structured domains and peptide motifs reveals functionally coherent subnetworks
Many protein–protein interactions (PPIs) are mediated by the binding of short linear motifs (SLiMs) to peptide recognition domains (PRDs). Here, we describe PrePPI-SLiM, a proteome-scale computational...
Performative planning creates a values mismatch between wildfire plans and community needs
To mitigate the potential impacts of wildfire, communities across the United States are engaging in collaborative wildfire risk mitigation planning. Planning involves identifying a set of goals, devel...
<i>BpFLC</i> coordinates seasonal and age-related flowering in <i>Betula platyphylla</i> through environmental cues and epigenetic regulation
The Flowering Locus C ( FLC ) gene is a flowering repressor in annual plants, but its function in perennial woody specie...
Structural insights into measles virus RNA synthesis regulation and pan-paramyxoviral polymerase inhibition by ERDRP-0519
Nonsegmented negative-sense RNA viruses (nsNSVs) rely on a multifunctional RNA-dependent RNA polymerase (RdRP) complex for transcription and replication. In measles virus (MeV), the nonstructural prot...
Microvesicle release drives cycles of mitophagy flux disruption and inflammatory amplification in sepsis-induced myocardial dysfunction
Sepsis-induced myocardial dysfunction strongly contributes to high mortality in patients with sepsis by exacerbating systemic organ failure; however, the onset and molecular mechanisms driving this vi...
Hyperactive Rac converts sublethal to lethal trogocytosis in vivo
The small GTPase Rac is an essential regulator of cell shape, migration, macropinocytosis, and phagocytosis. We found that expression of constitutively active Rac G12V...
Reply to Alexandre et al.: Insensitivity of the Δ <sup>′17</sup> O value of equisetum to atmospheric relative humidity
Oocyte-inspired universal whole-cell vaccines against tumor heterogeneity
Tumor heterogeneity poses a major challenge to tumor therapy due to the expression of unique, poorly recognized immunogenic proteins driven by environmental stress. The broad antigenic repertoire of c...
Building courage, strength, and knowledge: Mindfulness training reduces psychological threat and increases engagement in college physics
Many college students experience introductory physics as psychologically threatening. In a preregistered RCT, we applied the biopsychosocial model of challenge-threat to describe patterns of threat in...
Niche-dependent modular regulation of the stem cell transcriptome separates cell identity and potential
Adult stem cells maintain tissue homeostasis, yet are themselves vulnerable to loss. One common mechanism to replace lost stem cells is dedifferentiation, in which progeny revert to stem cell identity...
Hydraulic stress limits thermal acclimation in trees under chronic drought
The capacity of trees to withstand intensifying hot drought events depends on the coordination between hydraulic safety and leaf thermoregulation, yet the limits of this coordination under chronic str...
Reply to Godin-Beekmann et al.: Quantitative agreement between the CRE theory and spatiotemporal ozone observations is well founded
Single-cell insights: Mosquito Toll activation enhances granulocyte differentiation and immune surveillance via Notch suppression
Activation of the Toll, Immunodeficiency (IMD), Jun-kinase (JNK), and Signal Transducer and Activator of Transcription (STAT) innate immune signaling pathways limits Plasmodium...
Toward the simultaneous detection of multiple diseases with a highly cost-effective cell-free DNA methylome test
Plasma cell-free DNA (cfDNA), originating from multiple organs, holds significant potential for noninvasive diagnostics and prognostics. Current cfDNA methylation assays primarily focus on single clin...
Spider venom phospholipase D toxin structure: Interfacial binding site, mechanism, activation, and head group preference
Envenomation by sicariid spiders such as the brown recluse can cause loxoscelism, a syndrome involving localized dermonecrosis and/or systemic effects like hemolysis. The causative venom toxins are un...